Nitric Oxide in Health and Disease / Edition 1

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Overview

Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
"This is a timely and interesting monograph by a group of authors who are experts in their fields...readers will find this monograph a very interesting review of the literature on the areas of nitric oxide in arthritis and nitric oxide in bone." American Journal of Human Biology

"This manual is highly recommended to any scientist wishing to develop an interest in the subject. The practical experimental sections are particularly helpful." Journal of the Royal Society of Medicine

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Product Details

  • ISBN-13: 9780521559775
  • Publisher: Cambridge University Press
  • Publication date: 8/28/1997
  • Series: Biomedical Research Topics Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 377
  • Product dimensions: 6.85 (w) x 9.72 (h) x 0.79 (d)

Table of Contents

Preface
List of abbreviations
Sect. I Basic principles and recent advances
1 Nitric oxide: introduction and historical background 3
2 Synthesis and properties of nitric oxide 12
3 Endothelium-derived nitric oxide 27
4 Nitric oxide in the central nervous system 42
5 Nitric oxide in the peripheral nervous system 61
6 Nitric oxide in the immune system 83
Sect. 2 Pathological implications of nitric oxide
Introduction 103
7 Type II NOS and immune and inflammatory disorders 105
8 Type III NOS and cardiovascular disorders 114
9 Type I NOS and disorders of the central and peripheral nervous systems 125
Summary and future directions 135
Sect. 3 Experimental approaches
10 Molecular biology and biochemistry 139
11 Pharmacology 159
12 Microscopy 174
Sect. 4 Protocols and techniques
13 Measurement of nitric oxide 197
14 Measurement of nitric oxide synthase activity 215
15 Pharmacology 231
16 Microscopy 244
Appendix I 258
Appendix II 272
References 279
Index 356
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