Nitric Oxide in Health and Diseaseby Jill Lincoln, Charles H. V. Hoyle, Geoffrey Burnstock
Pub. Date: 08/28/1997
Publisher: Cambridge University Press
Nitric oxide has a tantalising role in health and disease: whilst many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad of effects of nitric oxide: as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to study nitric oxide in the laboratory.
Table of ContentsPart I. Basic Principles and Recent Advances: 1. Nitric oxide: introduction and historical background; 2. Synthesis and properties of nitric oxide; 3. Endothelium-derived nitric oxide; 4. Nitric oxide in the central nervous system; 5. Nitric oxide in the peripheral nervous system; 6. Nitric oxide in the immune system; Part II. Pathological Implications of Nitric Oxide: Introduction; 7. Type II NOS and immune inflammatory disorders; 8. Type III NOS and cardiovascular disease; 9. Type I NOS and disorders of the central and peripheral nervous systems; Summary; Part III. Experimental Approaches: 10. Biochemistry and molecular biology; 11. Pharmacology; 12. Microscopy; Part IV. Protocols and Techniques: 13. Measurement of nitric oxide; 14. Measurement of nitric oxide synthase activity; 15. Pharmacology; 16. Microscopy; Appendix I. Distribution of constitutive nitrogen oxide synthase in animal organs/tissues; Appendix II. Peripheral tissues and organs in which nitric oxide has been identified as a neurotransmitter; References.
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