Nitric Oxide in Transplant Rejection and Anti-Tumor Defense / Edition 1

Nitric Oxide in Transplant Rejection and Anti-Tumor Defense / Edition 1

by Stanislaw Lukiewicz
     
 

ISBN-10: 0792383893

ISBN-13: 9780792383895

Pub. Date: 11/30/1998

Publisher: Springer US

This book represents a unique combination of three interrelated topics that is unavailable in any other single work: (1.) The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; (2.) nitric oxide in immune mechanisms of allograft rejection; (3.) and the involvement of nitric oxide in anti-tumor defense. By…  See more details below

Overview

This book represents a unique combination of three interrelated topics that is unavailable in any other single work: (1.) The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; (2.) nitric oxide in immune mechanisms of allograft rejection; (3.) and the involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

Product Details

ISBN-13:
9780792383895
Publisher:
Springer US
Publication date:
11/30/1998
Edition description:
1998
Pages:
376
Product dimensions:
6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Preface
Acknowledgment
Pt. IElectron Paramagnetic Resonance Spectroscopy and Imaging as Research Tools
1EPR Detection of Nitrosylated Compounds: Introduction with some Historical Background
2Principles of EPR Spectroscopy for Measurement of Free Radicals in Biological Tissues
3EPR Studies and Biological Implications of Nitrosyl Nonheme Iron Complexes
4Enzyme Independent Formation of Nitric Oxide in Tissues
5Spin-Label No-Metry in Lipid Bilayer Membranes
6EPR Imaging of Free Radicals in Biological Systems
7Electron Paramagnetic Resonance Imaging of Nitric Oxide in Tissues
Pt. IIAllo- and Xenograft Rejection
8Allograft Rejection: Fact and Fancy
9Immunobiology of Transplants: Specific and Nonspecific Mechanisms Involved in Allograft Rejection
10Animal EPR Studies on Allo- and Xenograft Rejection
11Nitric Oxide effects on Murine Cardiac Allografts
12Accelarated Rejection of Cardiac Allo- and Xenografts in Pre-Sensitized Rats and Gerbils
13Involvement of Nitric Oxide in Amphibian Transplantation Immunity
Pt. IIIAntitumor Immune Responses
14Interactions between Cytokine Induced Nitric Oxide and Intracellular Iron229
15Molecules Involved in the Recruitment and Regulation of Tumor-Associated Macrophages
16The Role of Macrophage-Derived Nitric Oxide in Tumor Cell Death
17Transcriptional Regulation of the Macrophage NOS2 Gene
18Infection, Inflammation and Cancer Mediated by Oxygen Radicals and Nitric Oxide
19Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress
20EPR Analysis of Tumor-Host Interactions
21Ambivalent Role for no in the Antitumor Immune Response
22Identification of Nitric Oxide-Derived EPR Signals in Human Cancers
23EPR Signals Detectable in Human Tumors
Subject Index

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