Nitric Oxide in Transplant Rejection and Anti-Tumor Defense / Edition 1

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Overview

This book represents a unique combination of three interrelated topics that is unavailable in any other single work: (1.) The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; (2.) nitric oxide in immune mechanisms of allograft rejection; (3.) and the involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Bradley D. Freeman, MD (Washington University School of Medicine)
Description: This is a multiauthored text covering recent advances in nitric oxide research, focusing on the areas of the role of nitric oxide in tumor immunology and transplant rejection.
Purpose: The purpose is to take a multidisciplinary approach to nitric oxide research. Specifically, the editors are interested in the application of electron paramagnetic resonance spectroscopy as an investigative technique in this field.
Audience: This book would be of interest to investigators in the field of nitric oxide, both in general and particularly in the domains of transplantation and oncology.
Features: The text is divided into three broad areas: methodology, tumor immunology, and transplant rejection. The chapters in each of these areas are authoritatively and concisely written, covering the salient aspects of current nitric oxide research.
Assessment: This text provides comprehensive coverage of current topics in nitric oxide research. Further, it appears unique in that it applies electron paramagnetic resonance spectroscopy to nitric oxide investigation. For these two reasons, it would appear to be a useful addition to the library of the nitric oxide researcher.
Bradley D. Freeman
This is a multiauthored text covering recent advances in nitric oxide research, focusing on the areas of the role of nitric oxide in tumor immunology and transplant rejection. The purpose is to take a multidisciplinary approach to nitric oxide research. Specifically, the editors are interested in the application of electron paramagnetic resonance spectroscopy as an investigative technique in this field. This book would be of interest to investigators in the field of nitric oxide, both in general and particularly in the domains of transplantation and oncology. The text is divided into three broad areas: methodology, tumor immunology, and transplant rejection. The chapters in each of these areas are authoritatively and concisely written, covering the salient aspects of current nitric oxide research. This text provides comprehensive coverage of current topics in nitric oxide research. Further, it appears unique in that it applies electron paramagnetic resonance spectroscopy to nitric oxide investigation. For these two reasons, it would appear to be a useful addition to the library of the nitric oxide researcher.
Booknews
Contains 23 contributions, the first seven of which address methodological problems, stressing the suitability of electron paramagnetic resonance spectroscopy and imaging as tools suitable for the examination of nitric oxide in normal and neoplastic tissues. The following six contributions address immune reactions of mammals and amphibians to allo- and xenografts, while the last part contains ten articles addressing results in spectroscopic terms of the above methodology and others, based on more conventional analytic approaches which rely on parameters such as biochemical composition, histopathological evaluation, the number of infiltrating macrophages, physiological activity, rate of tumor growth, number of metastases, and survival time of tumor bearing animals. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780792383895
  • Publisher: Springer US
  • Publication date: 11/30/1998
  • Edition description: 1999
  • Edition number: 1
  • Pages: 392
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

Preface
Acknowledgment
Pt. I Electron Paramagnetic Resonance Spectroscopy and Imaging as Research Tools
1 EPR Detection of Nitrosylated Compounds: Introduction with some Historical Background
2 Principles of EPR Spectroscopy for Measurement of Free Radicals in Biological Tissues
3 EPR Studies and Biological Implications of Nitrosyl Nonheme Iron Complexes
4 Enzyme Independent Formation of Nitric Oxide in Tissues
5 Spin-Label No-Metry in Lipid Bilayer Membranes
6 EPR Imaging of Free Radicals in Biological Systems
7 Electron Paramagnetic Resonance Imaging of Nitric Oxide in Tissues
Pt. II Allo- and Xenograft Rejection
8 Allograft Rejection: Fact and Fancy
9 Immunobiology of Transplants: Specific and Nonspecific Mechanisms Involved in Allograft Rejection
10 Animal EPR Studies on Allo- and Xenograft Rejection
11 Nitric Oxide effects on Murine Cardiac Allografts
12 Accelarated Rejection of Cardiac Allo- and Xenografts in Pre-Sensitized Rats and Gerbils
13 Involvement of Nitric Oxide in Amphibian Transplantation Immunity
Pt. III Antitumor Immune Responses
14 Interactions between Cytokine Induced Nitric Oxide and Intracellular Iron 229
15 Molecules Involved in the Recruitment and Regulation of Tumor-Associated Macrophages
16 The Role of Macrophage-Derived Nitric Oxide in Tumor Cell Death
17 Transcriptional Regulation of the Macrophage NOS2 Gene
18 Infection, Inflammation and Cancer Mediated by Oxygen Radicals and Nitric Oxide
19 Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress
20 EPR Analysis of Tumor-Host Interactions
21 Ambivalent Role for no in the Antitumor Immune Response
22 Identification of Nitric Oxide-Derived EPR Signals in Human Cancers
23 EPR Signals Detectable in Human Tumors
Subject Index
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