Non-Dietary Human Exposure and Risk Assessment

Non-Dietary Human Exposure and Risk Assessment

by Michael Krolski
     
 

ISBN-10: 0841225885

ISBN-13: 9780841225886

Pub. Date: 05/05/2011

Publisher: American Chemical Society

The Protection of Subjects in Human Research rule by the USEPA, including the establishment of the Human Studies Review Board (HSRB), has resulted in changes to both study design and study evaluation processes, particularly with respect to ethical considerations. Non-Dietary Human Exposure and Risk Assessment is a compilation of the presentations given in a

Overview

The Protection of Subjects in Human Research rule by the USEPA, including the establishment of the Human Studies Review Board (HSRB), has resulted in changes to both study design and study evaluation processes, particularly with respect to ethical considerations. Non-Dietary Human Exposure and Risk Assessment is a compilation of the presentations given in a symposium of the same name at the 238th ACS National Meeting in Washington D.C. The purpose of the symposium was to provide a forum for scientists from industry, academia, and government to share investigative methods used to generate data for use in non-dietary human risk assessments and to share methodology for performing and evaluating those assessments.

This compilation is intended to provide the reader with a concise overview of the current status of both the scientific and regulatory aspects of non-dietary human exposure and risk assessment as applied to pesticides. It is the hope of the editors that it will also be the starting point for discussions leading to the further refinement of study and risk assessment design, data evaluation, and regulatory harmonization.

Three major areas are covered in this symposium edition. The first area is regulatory issues including the development of the Protection of Subjects in Human Research rule and the HSRB, statistical procedures involved in designing human exposure studies, handling of the data generated in those studies, and quality assurance processes related to worker exposure studies. The second area, study design, includes processes for the identification and recruitment of volunteers for human exposure studies, overviews of several studies that have been recently performed, the development of procedures for evaluating the resulting data by Regulatory Agencies, and efforts towards international cooperation in the generation and use of exposure data. The final area, methodology, includes examples of the development of methods for the analysis of samples generated in non-dietary human exposure studies with particular emphasis on the use of hyphenated techniques and the development of a model for determining greenhouse exposures that is currently being used in Europe.

Product Details

ISBN-13:
9780841225886
Publisher:
American Chemical Society
Publication date:
05/05/2011
Series:
ACS Symposium Series, #1047
Pages:
128
Product dimensions:
6.10(w) x 9.00(h) x 0.60(d)

Table of Contents

Preface
1. Non-Dietary Human Exposure and Risk Assessment: Regulatory Issues
Curt Lunchick and Michael E. Krolski
2. Establishment of the Human Studies Review Board (HSRB)
Elliot Gordon
3. Impact of Human Studies Review Board on Agricultural Worker Exposure Studies
Leah Rosenheck
4. Comparison of Deterministic and Probabilistic Approaches to Modeling Dermal Exposure to Pesticides during Orchard Airblast Application
Douglas G. Baugher
5. Experimental Design in the AHETF Exposure Monitoring Program
Larry R. Holden and Douglas G. Baugher
6. Effect of Changes in Human Exposure Regulations on Quality Assurance
Randy Fuller
7. Design of an Observational Worker Exposure Study in Commercial Seed Treatment Facilities
Michael E. Krolski, Curt Lunchick, and Joel Panara
8. Exposure to Pesticides in the Greenhouse: A New Modeling Approach in Europe
H. Wicke
9. Analytical Methods Developed for an Observational Worker Exposure Study Involving Multiple Target Compounds
I. M. Murphy and S. Schowengerdt
Indexes
Author Index
Subject Index

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