Non-Motor Symptoms Complex of Parkinson's Disease

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Overview

The classical motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the non-motor symptoms (NMS) of Parkinson's disease, which are often poorly recognized. The non-motor symptoms of Parkinson's disease have a negative impact on patient quality of life, morbidity, and mortality. While some NMS can be improved with currently available treatments, others can be more refractory and require research into novel (non-dopaminergic) drug therapies for the future.

Edited by key international experts in the field of non-motor symptoms of Parkinson's disease and with contributions from leading specialists, this book summarizes the current understanding of NMS in Parkinson's disease and points the way towards future research. The book focuses on the NMS complex in a unified manner, bringing together all the diverse symptoms of the NMS complex in PD in one book. Individual chapters concentrate on the available evidence in relation to the pathophysiology, clinical presentation, and treatment of NMS. The book serves as an invaluable reference for movement disorder specialists, neurologists, geriatricians, trainees, nurse specialists, other healthcare professionals who care for people with Parkinson's, and their caregivers.

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Editorial Reviews

Doody's Review Service
Reviewer: Joseph I Sirven, MD (Mayo Clinic Arizona)
Description: This is thought to be the first truly comprehensive book dealing with the range of nonmotor symptoms seen in Parkinson's disease. Key international experts and opinion leaders have contributed their experience and expertise to 29 chapters on various nonmotor symptoms of Parkinson's disease. Topics range from olfactory problems, depression, and sleep disorders to dementia, pain, bladder or bowel dysfunction, and dribbling of saliva.
Purpose: For years, the nonmotor symptoms of Parkinson's have remained underresearched, misunderstood, misrepresented, and underreported. They may predate the motor syndrome of Parkinson's and, thus, may in the future allow detection of people at risk of Parkinson's and aid in the effort to discover effective neuroprotective therapy for Parkinson's. The task here is to improve the deficiencies in our knowledge to provide better treatment delivery and quality of life for our patients.
Audience: The book serves as an invaluable reference for movement disorder specialists, neurologists, geriatricians, and other healthcare professionals who care for people with Parkinson's. Researchers who are focusing on further studies to address the role of nonmotor symptoms and the effect of treatment as well as future drug therapy to improve the health and quality of life of patients also would be interested.
Features: Chapters are devoted to various nonmotor symptoms and premotor diagnosis of Parkinson's, nonmotor symptoms in early motor stages and in advanced Parkinson's, and in genetic forms of Parkinson's. Cognitive dysfunction is discussed as well as depression, anxiety, apathy, dementia, fatigue, and psychosis. Also considered are sleep disorders, bladder dysfunction, gastrointestinal problems, sexual disorders, restless leg syndrome, chronic pain, and ophthalmologic difficulties, as well as a few others. Assessment tools and imaging are also noted.
Assessment: This is an extensive collection of research articles that summarizes the current understanding of nonmotor symptoms in Parkinson's and points the way to future research. It is a great reference guide and thought-provoking book.
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Product Details

  • ISBN-13: 9780199237234
  • Publisher: Oxford University Press, USA
  • Publication date: 8/10/2009
  • Pages: 394
  • Product dimensions: 6.60 (w) x 9.70 (h) x 1.10 (d)

Table of Contents

List of contributors ix

1 What are the non-motor symptoms of Parkinson's disease? K. Ray Chaudhuri Niall Quinn 1

2 Non-motor symptoms and pre-motor diagnosis of Parkinson's disease David A. Gallagher Anthony H. V. Schapira 7

3 Non-motor symptoms in the early motor stages of Parkinson's disease Eduardo Tolosa Carles Gaig Joan Santamaria Yaroslau Compta 19

4 Non-motor symptoms in advanced Parkinson's disease Miguel Coelho Joaquim J. Ferreira 37

5 Assessment tools for non-motor symptoms of Parkinson's disease Pablo Martinez-Martin Johan Marinus Jacobus J. van Hilten 47

6 Imaging non-motor aspects of Parkinson's disease David J. Brooks Nicola Pavese 59

7 Non-motor signs in genetic forms of Parkinson's disease Meike Kasten Christine Klein 73

8 Cognitive dysfunction of Parkinson's disease Daisy L. Whitehead Richard G. Brown 95

9 Depression, anxiety and apathy in Parkinson's disease David A. Gallagher Anette Schrag 107

10 Dementia in Parkinson's disease David J. Burn 121

11 Fatigue in Parkinson's disease Benzi M. Kluger Joseph H. Friedman 135

12 Psychosis in Parkinson's disease Christopher G. Goetz Nico J. Diederich Gilles Fénelon 147

13 Neurobiology of sleep: the role of dopamine in Parkinson's disease Lynn Marie Trotti David B. Rye 165

14 REM sleep behaviour disorder in Parkinson's disease Alex Iranzo Eduardo Tolosa 177

15 Parkinson's disease and restless legs syndrome William G. Ondo 195

16 Excessive daytime sleepiness in Parkinson's disease Birgit Frauscher Werner Poewe 205

17 Bladder dysfunction in Parkinson's disease Clare J. Fowler Ryuji Sakakibara 215

18 Sexuality in Parkinson's disease Orna Moore Gila Bronner Nir Giladi 225

19 Gastrointestinal dysfunctions in Parkinson's disease Fabrizio Stocchi 241

20 Postural hypotension in Parkinson's disease Italo Biaggioni Horacio Kaufmann 255

21 Sialorrhoea in Parkinson's disease Marian L. Evatt Julia Johnson Sharon Muzerengi K. Ray Chaudhuri 271

22 Olfaction in Parkinson's disease Heinz Reichmann Birgit Herting 279

23 Chronic pain and Parkinson's disease Olivier Rascol Laurence Nègre-Pagès Christine Brefel-Courbon Ana Senard Angélique Gerdelat-Mas Wafa Regragui Tarik Slaoui Nadine Attal Didier Bouhassira 287

24 Ophthalmological aspects of Parkinson's disease Louise Bye Padman Vamadevan K. Ray Chaudhuri 297

25 Non-motor symptoms and health-related quality of life Pablo Martinez-Martin Francisco J. Carod Artal Jesus de Pedro Cuesta 309

26 Non-motor symptoms and co-morbidity in Parkinson's disease Graeme J. A. MacPhee Douglas G. MacMahon 321

27 Non-motor symptoms of Parkinson's disease and the effects of deep brain stimulation Shen-Yang Lim Elena Moro Anthony E. Lang 339

28 Impulse dyscontrol and dopamine dysregulation syndrome Regina Katzenschlager Andrew Evans 353

29 Treatment-related non-motor symptoms in Parkinson's disease Andreas Matusch J. Carsten Möller Marcus M. Unger Wolfgang H. Oertel 369

Index 383

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