Non-Myeloablative Allogeneic Transplantation / Edition 1

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Overview

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

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Product Details

  • ISBN-13: 9780792376460
  • Publisher: Springer US
  • Publication date: 2/28/2002
  • Series: Cancer Treatment and Research Series , #110
  • Edition description: 2002
  • Edition number: 1
  • Pages: 216
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.56 (d)

Table of Contents

Contributors
Preface
1 Development of allogeneic hematopoietic stem cell transplantation (HSCT) 1
2 Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation 39
3 Mobilization of allogeneic peripheral blood progenitor cells 51
4 Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies 79
5 Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer 101
6 Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice 113
7 Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy 137
8 Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans 149
9 Non-myeloablative transplants for congenital diseases 177
Index 213
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