Novel Vaccination Strategies / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$184.65
Used and New from Other Sellers
Used and New from Other Sellers
from $18.42
Usually ships in 1-2 business days
(Save 92%)
Other sellers (Hardcover)
  • All (10) from $18.42   
  • New (6) from $195.05   
  • Used (4) from $18.42   

Overview

The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines.
This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates.
Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Read More Show Less

Editorial Reviews

From the Publisher
"...enjoyed reading the book immensely, found it very informative and a good mixture of basic and applied science...definitely recommended..."

Immunology News, August 2004

"This would be a valuable text for those in the field with the expertise."

E-STREAMS, October 2004

"This book thoroughly reviews our understanding of the immunologic response to infectious diseases and the many advances in the development of vaccines...Stefan Kaufmann, who is the founding director of the Max Planck Institute for Infection Biology in Berlin, has brought together a group of experts in various fields of vaccinology from Europe, the United States, and Australia for this challenging project. Immunologists, developers of vaccines, clinical-trial specialists, and molecular biologists will find this book to be of interest...An outstanding section of the book is dedicated to adjuvants and vaccine vectors...I recommend this book to microbiologists, epidemiologists, and practitioners who administer vaccines. Indeed, reading the chapter...is fascinating for all specialists."

New England Journal of Medicine, November 4, 2004

"The presentations are concise, clear, well illustrated, and provide an excellent survey of the subject overall."
IEEE Engineering in Medicine and Biology, Jan/Feb 2005

"Dr. Kaufmann and eminent contributors, with their outstanding expertise, created an excellent resource for medical professionals and biomedical scientists."
Annals of Biomedical Engineering, December 2004

Read More Show Less

Product Details

  • ISBN-13: 9783527305230
  • Publisher: Wiley
  • Publication date: 3/28/2004
  • Edition number: 1
  • Pages: 670
  • Product dimensions: 6.84 (w) x 9.70 (h) x 1.52 (d)

Meet the Author

Prof. Dr. Stefan H.E. Kaufmann, Scientific member of the Max Planck Society, Founding Director of the Max Planck Institute for Infection Biology, Berlin. More than 500 publications and reviews on immunology and infection. Member of numerous scientific societies and committees and winner of prestigious awards. One of the 100 most cited immunologists in the period of 1981 to 1999.

Read More Show Less

Table of Contents

PART I
Preface
Introduction: Challenges for the vaccine developer, including correlates of protection

PART II
VACCINATION AND IMMUNE RESPONSE
Shaping adaptive immunity against pathogens: the contribution of innate immune responses
Adjuvant induced Th2 and Th1 dominated immune responses in vaccination
Memory
T-cell based vaccines

PART III
ADJUVANTS
Microbial adjuvants
Host derived adjuvants
Microparticles as vaccine adjuvants and delivery systems
Liposomes and ISCOMs
Virosomal technology and mucosal adjuvants

PART IV
CLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISON
Classical bacterial vaccines
Subunit vaccines and toxoids
Engineering virus vectors for subunit vaccines
Update on antiviral DNA vaccine research (2000-2003)
Live recombinant bacterial vaccines
Mucosal vaccination
Passive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodies
Plant-based oral vaccines
Virus-like particles: Combining innate and adaptive immunity for effective vaccination

PART V
VACCINES FOR SPECIFIC TARGETS
Helicobacter pylori
Tuberculosis: Novel vaccination strategies against tuberculosis
Rationale for malaria vaccine development
HIV
Vaccines against bioterror agents

Part VI
VACCINES IN THE REAL WORLD: SAFETY, COST-EFFICIENCY AND IMPACT OF VACCINATION
Imperfect vaccines and the evolution of pathogen virulence
Cost-effectiveness of vaccinations
Immunological safety of vaccines: facts, hypothesis and allegations

Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)