Nutrient-Drug Interactions

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Current research has given us a more complete understanding of how the chemicals in foods and herbs interact with natural and synthetic drugs. In some cases a single food or supplement can profoundly increase or decrease the toxicity and/or efficacy of a single drug. Although it is standard practice to examine the effects of food consumption on the absorption and pharmacokinetics of new drugs, the issue has become greater than "should this medicine be taken with or without food."

Nutrient-Drug Interactions focuses on food, herbals, and their chemical constituents as contributors to human health through control of metabolism, primarily as they relate to chronic disease development and treatment. The book's organization highlights the ailment being treated or prevented and the targets of therapy. Each chapter provides a comprehensive examination of the macronutrient, micronutrient, and phytochemical impact on drug action and includes advice on modification or supplementation in those cases where diet is a factor. The chapters focus on the molecular mechanism by which a food or chemical is thought to modify disease process and drug behavior. The book describes the roles of genetic variation and polymorphism in determining nutrient/drug responses, how they might be "profiled" to identify those likely to demonstrate specific interactions, and who would benefit from adjuvant or complementary therapies.

The book explores how what is consumed affects response, whether on a population or individual level, to the pharmacologic agents that are the mainstay of chronic disease treatment/prevention around the world.

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Editorial Reviews

Doody's Review Service
Reviewer: Paul R Hutson, Pharm.D., M.S.(University of Wisconsin)
Description: This book provides an up-to-date summary of disease-based pathobiology and the mechanism of drug classes currently used in each disease. In this context, the chapters then introduce nutrients or dietary supplements that may enhance or attenuate the effect of the drugs.
Purpose: The editor's purpose is to present evidence-based summaries of the effects of food and herbals upon commonly used drugs. This is a timely and useful objective, as there is a burgeoning amount of new information on disease processes, pharmacologic mechanisms, and in vitro and clinical effects of dietary supplements. This book is helpful in providing a mechanistic understanding of how drug-nutrient interactions might be expected, or have been proven to occur. Different chapter authors provide varying degrees of interpretation of the magnitude and clinical impact of these interactions.
Audience: The book is clearly written and provides sufficient background to allow students and practitioners alike to understand the mechanisms of the interactions. The limited detail of clinical study results or of their clinical implications limits the utility of the book to practicing physicians, pharmacists, and dieticians. However, it does provide extremely useful distillations by experts in their fields that will be appreciated by those seeking a mechanistic understanding of drug-supplement interactions that will guide their clinical decisions.
Features: The topics covered in this book reflect the diseases for which the public most commonly uses dietary supplements. These include cancer treatment and prevention, dyslipidemias, and neurodegenerative or psychiatric disorders. In addition, useful chapters cover interactions with anesthetic agents, and gene expression effects that may have clinical relevance. There are limited figures, and none are in color. Additional figures to illustrate biochemical pathways would be helpful, as would tables to summarize the magnitude of any effects noted in pivotal clinical trials of the supplements considered.
Assessment: This book is well written and provides a mechanistic understanding of the known or likely effects of components found in common dietary supplements as they relate to the functioning of major drug classes. While the scope of the book excludes consideration of some dietary supplements such as CoQ10 or glucosamine, the book does provide an extremely helpful framework by which the effects and interactions of drugs and nutrients can be understood. In this regard, it is more helpful in providing a mechanistic understanding than other books and references such as the Natural Medicines Comprehensive Database, 8th edition (Pharmacists Letter, 2005), or Drug Facts and Comparisons 2006, 60th edition (Wolters Kluwer Health, 2005).
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Product Details

Table of Contents

Diabetes, Obesity and Metabolic Syndrome, A.J. Scheen

Hypolipidemic Therapy: Drugs, Diet, and Interactive Effects, A. Loktionov

Phytochemicals, Xenobiotic Metabolism, and Carcinogenesis, J.B. Kirkland

Nutrient and Phytochemical Modulation of Cancer Treatment, K.A. Meckling

Role of Nutritional Antioxidants in the Prevention and Treatment of Neurodegenerative Disorders, E. Esposito

Nutrients and Herbals in the Pharmacotherapy of Unipolar/Major Depression, M. Chronowic

Supplements and Anesthesiology, A.D. Kaye, A. Baluch, and J.M. Hoover

Nutrient and Drug Responsive Polymorphic Genes as Nutrigenomic Tools for Prevention of Cardiovascular Disease and Cancer, K. Wood and M. Bakovic

Nutrigenomics and Pharmacogenomics of Human Cancer: On the Road from Nutrigenetics and Pharmacogenetics, A. Loktionov

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