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Nutrition in the Prevention and Treatment of Disease [NOOK Book]


Expertly edited, the Second Edition of Nutrition in the Prevention and Treatment of Disease offers 18 completely new chapters and 50% overall material updated. Given its unique focus and extensive coverage of clinical applications and disease prevention, this edition is organized for easy integration into advanced upper-division or graduate nutrition curriculums. Foundation chapters on nutrition research methodology and application clearly link the contributions of basic science to applied nutrition research and,...
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Nutrition in the Prevention and Treatment of Disease

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Expertly edited, the Second Edition of Nutrition in the Prevention and Treatment of Disease offers 18 completely new chapters and 50% overall material updated. Given its unique focus and extensive coverage of clinical applications and disease prevention, this edition is organized for easy integration into advanced upper-division or graduate nutrition curriculums. Foundation chapters on nutrition research methodology and application clearly link the contributions of basic science to applied nutrition research and, in turn, to research-based patient care guidelines. Readers will learn to integrate basic principles and concepts across disciplines and areas of research and practice as well as how to apply this knowledge in new creative ways.

Chapters on specific nutrients and health cover topics where data are just beginning to be identified, such as choline, antioxidants, nutrition and cognition, and eye disease. Established areas of chronic disease: obesity, diabetes, cardiovascular disease, gastrointestinal disease, and bone health are presented each in their own sections, which aim to demonstrate the inter-action of basic science, genetics, applied nutrition research, and research-based patient care guidelines. No other nutrition book on the market takes this approach. Students will take away foundational insights into the application of nutrition research in the prevention and treatment of disease. Busy researchers and clinicians will use this book as a “referesher course? and should feel confident in making patient care recommendations based on solid current research findings.

* 18 completely new chapters and 50% overall new material
* Unique focus and extensive coverage of clinical applications and disease prevention.
* Clearly links the contributions of basic science to applied nutrition research and, in turn, to research-based patient care guidelines.
* Assimilates a large body of research and applications and serves as a “refresher course? for busy researchers and clinicians.

Audience: Dietitians, epidemiologists, primary care physicians, nurse practitioners, family medicine physicians, and nutritionists.

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Editorial Reviews

N.S. Springer excellent and timely addition to the field of clinical nutrition. ...A valuable resource,not only for nutrition students,but also for practicing nutrition professionals.
Martijn B. Katan
It is strong on strategies for dietary modification and on cultural and socioeconomic influences on eating and exercise behavior. Unlike earlier textbooks,it has large sections on the genetic influences on nutritional health. a useful additional resource for nutritional investigators and for dietitians involved in research.
D. Lee Alekel
This text with 48 chapters provides an excellent overview of clinical nutrition,integrating the collective role of diet,genetics,environment,and behavior in health and disease. ...All in all,this text is a comprehensive contribution to the field of clinical nutrition and provides an excellent reference for practitioners,researchers,and advanced nutrition students.
From The Critics
Provides an update of current knowledge in clinical nutrition and an overview of the rationale and scientific basis of its application in the treatment and prevention of disease. Contributors, including hospital-, research-, and academia-based physicians, epidemiologists, oncologists, nutritionists, and others offer 48 contributions that are organized into two main sections. The first part, addressing basic concepts, covers the relationship between diet, nutrition, and disease; nutrition intervention; genetic influences on nutritional health; and supplements and food replacements. In the second section, focusing on disease-specific intervention, topics include cardiovascular disease; cancer prevention and therapy; diabetes mellitus; obesity; gastrointestinal diseases; and other major diseases. A final piece discusses overall disease prevention. Annotation c. Book News, Inc., Portland, OR (
Doody's Review Service
Reviewer: Amy Hess-Fischl, MS, RD, LDN, BC-ADM, CDE (University of Chicago Medical Center)
Description: This compilation of up-to-date research and science-based nutrition principles updates the 2008 edition.
Purpose: The purpose is to present the current knowledge in clinical nutrition as well as an overview of the rationale and scientific basis of its application to practice in the prevention and treatment of disease. It is a daunting task, but the book meets it objectives.
Audience: The level at which the book is written presumes readers already have a good knowledge of nutrition, making it appropriate for those in undergraduate programs in nutrition and dietetics or for graduate courses in nutrition. It would also be ideal as a reference for dietitians working in all areas of nutrition, as well as for other healthcare professionals.
Features: The book is divided into two sections: research methodology and nutrition for health maintenance, prevention, and disease-specific treatment, and it covers a lot of ground. Chapters on nutrition assessment methodology and on application of research paradigms to nutrition practice are just two of the 12 in the research section. The second section includes some new chapters, with an entire section on bioactive compounds for health, which delves into antioxidants and phytochemicals, focusing on their role in cognition, eye disease, and obesity. Additional chapters in the obesity section focus on the management of patients who have undergone surgical treatment. Since this has become more common in all areas of care, this chapter is a must-read for all healthcare professionals. The book covers all disease states and nutrition management and prevention, providing some practical information about cardiovascular disease, diabetes, and cancer, as well gastrointestinal disease and bone disease. The one topic that is not covered is renal disease. The many tables, figures, and photos help readers with understanding.
Assessment: As a registered dietitian, I found a lot of practical information that helped me with some disease states that I do not focus on in my daily practice. While this book would be best used by dietitians, it can be a good resource for all healthcare professionals working with patients. In the past five years, new research has emerged regarding nutrition and its role in disease management as well as prevention, so this update is needed.
From the Publisher

Praise for the Third Edition:

"I think this book is remarkably useful to people like me; a practicing physician. There is a pleasant uniformity to the prose suggesting that the editors have done a great job in homogenizing, as it were, the style. The chapters I read were really informative--I particularly liked chapter 3, which had a wealth of information about the physical manifestations of malnutrition. I was completely unaware of most of them and found this very useful; in fact, it will add a great deal to how well I can assess the nutritional status of my patients and how to help them remedy deficiencies in their diet. This book should be a great success!"

--Mariane Legato, MD, FACP, Professor Emerita of Clinical Medicine, Columbia University College of Medicine, New York, NY; Adjunct Professor of Medicine, Johns Hopkins, Department of Medicine, Baltimore, MD, USA

"In this third edition, the editors continue to identify key experts in nutrition science who discuss in depth a broad spectrum of topics from basic concepts of nutrient requirements to a translational research model calling for interdisciplinary approaches linking discoveries at the molecular level to individual and public health. This book is a wonderful resource!"

-- Mary Jo Feeney, MS, RD, FADA, Consultant to Food and Agricultural Industries, Los Altos, CA, USA

Praise for Previous Editions:

"With Nutrition in the Prevention and Treatment of Disease, instructors have access to one comprehensive text to demonstrate the nutrition link to disease. is a text a nutrition professional can feel confident in recommending to their clinical and community nutrition colleagues, as well as to dietetics students, epidemiologists and medical students."

--JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION "It is strong on strategies for dietary modification and on cultural and socioeconomic influences on eating and exercise behavior. Unlike earlier textbooks, it has large sections on the genetic influences on nutritional health. a useful additional resource for nutritional investigators and for dietitians involved in research."

--THE NEW ENGLAND JOURNAL OF MEDICINE "Written by nutrition researchers and dieticians with extensive clinical experience, this book is a useful addition to the clinical nutritionist's bookshelf."

--AMERICAN JOURNAL OF CLINICAL NUTRITION " excellent and timely addition to the field of clinical nutrition. ...A valuable resource, not only for nutrition students, but also for practicing nutrition professionals."

--CHOICE "...provides an excellent overview of clinical nutrition, integrating the collective role of diet, genetics, environment, and behavior in health and disease. ...All in all, this text is a comprehensive contribution to the field of clinical nutrition and provides an excellent reference for practitioners, researchers, and advanced nutrition students."


3 Stars from Doody
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Product Details

Meet the Author

Ann M. Coulston, MS, RD, has a more than 20-year history of clinical research at Stanford University Medical Center where her research centered on carbohydrate and lipid metabolism, the nutritional management of diabetes, and insulin resistance. She has provided nutrition consultation to the food and healthcare industry, public relations firms, and Internet companies. She is past-president of the Academy of Nutrition and Dietetics (formerly the American Dietetic Association) and has been recognized by the American Dietetic Association Foundation for excellence in the practice of clinical nutrition and the practice of research.

Carol J. Boushey, PHD, MPH, RD, is an Associate Researcher in the Epidemiology Program of the University of Hawaii Cancer Center and an Adjunct Professor in the Nutrition Science Department at Purdue University. Her research includes dietary assessment methods, dietary patterns, and quantitative methods. At the Cancer Center, she directs the Nutrition Shared Resource. She serves on the editorial board of the Journal of the Academy of Nutrition and Dietetics and the Nutrition Committee of the American Heart Association.

Mario G. Ferruzzi, PhD is a Professor of Food Science and Nutrition at Purdue University. His research interests are in the area of phytochemical bioavailability, metabolism and their role in chronic disease prevention. Additionally, he has industrial experience in product research and development. Prior to joining Purdue in 2004, he was a Research & Development Scientist with Nestlé R&D in Marysville, OH and Lausanne, Switzerland. He is a member of the Institute of Food Technologists (IFT), the American Society for Nutrition (ASN), and the American Chemical Society (ACS).

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Read an Excerpt

From Chapter 1: Dietary Assessment Methodology

I.INTRODUCTION This chapter reviews the major dietary assessment methods, their advantages and disadvantages,and specific issues to consider when collecting these types of data. The intent is for this chapter to lead to an understanding of alternative dietary assessment methods so that the appropriate method is chosen for a particular need. This chapter updates the "Dietary Assessment Resource Manual"[1]. II.DIETARY ASSESSMENT METHODS A.Dietary Records For the dietary record approach,the respondent records the foods and beverages and the amounts of each consumed over 1 or more days. The amounts consumed may be measured, using a scale or household measures (such as cups, tablespoons), or estimated, using models, pictures, or no particular aid. Typically, if multiple days are recorded, they are consecutive, and no more than 3 or 4 days are included. Recording periods of more than 4 consecutive days are usually unsatisfactory, as reported intakes decrease[2] because of respondent fatigue. Theoretically, the recording is done at the time of the eating occasion, but it need not be done on paper. Dictaphones, computer recording, and self-recording scales have been used [3-5] and hold special promise for low-literacy groups and other difficult-to-assess populations because of their ease of administration and potential accuracy,although tape recording has not been shown to be useful among school-aged children [6].

To complete a dietary record, the respondent must be trained in the level of detail required to adequately describe the foods and amounts consumed, including the name of the food (brand name, if possible), preparation methods, recipes for food mixtures, and portion sizes. In some studies this is enhanced by contact and review of the report after 1 day of recording. At the end of the recording period, a trained interviewer should review the records with the respondent to clarify entries and to probe for forgotten foods. Dietary records can also be recorded by someone other than the subject. This is often done with children or institutionalized individuals.

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Table of Contents

Section 1: Research Methodology
A. Assessment Methods for Research and Practice
Dietary Assessment Methodology
Assessment of Dietary Supplement Use
Physical Assessment of Nutritional Status
Energy Requirement Methodology
B. Research and Applied Methods for Observational and Intervention Studies
Application of Research Paradigms to Nutrition Practice
Overview of Nutritional Epidemiology
Analysis, Presentation, and Interpretation of Dietary Data
Current Theoretical Bases for Nutrition Intervention and their Uses
Nutrition Intervention: Lessons from Clinical Trials
Tools and Techniques to Facilitate Nutrition Intervention
Evaluation of Nutrition Interventions
Biomarkers and their Use in Nutrition Intervention
Section 2: Nutrition for Health Maintenance, Prevention and Disease-Specific Treatment
A. Food and Nutrient Intake for Health
Nutrition Guidelines to Maintain Health
Nutrition, Health Policy, and the Problem of Proof
Choline and Neural Development
Antioxidants in Health and Disease
Nutrients and Food Constituents in Cognitive Decline and Neurodegenerative Disease
Diet and Supplements in the Prevention and Treatment of Eye Diseases
Nutrition Requirements for Athletes
Nutrition for Children with Special Health Care Needs
B. Overweight and Obesity
Genetics of Human Obesity
Obesity: Overview of Treatments and Interventions
Obesity: The Role of Physical Activity in Adults
Macronutrient Intake and the Control of Body Weight
Behavioral Risk Factors for Obesity: Diet and Physical Activity
Dietary Approaches to Exploit Energy Balance Utilities for Body Weight Control
Properties of Foods and Beverages that Influence Energy Intake and Body Weight
C. Cardiovascular Disease
Genetic Influences on Blood Lipids and Cardiovascular Risk
The Role of Diet in the Prevention and Treatment of Cardiovascular Disease
Nutrition, Lifestyle and Hypertension
D. Diabetes Mellitus
Obesity and the Risk for Diabetes
Nutritional Management of Diabetes Mellitus
Nutrition Management for Gestational Diabetes
E. Cancer
Interaction of Nutrition and Genes in Carcinogenesis
Nutrition and Cancers of the Breast, Endometrium and Ovary
Nutrition and Prostate Cancer
Nutrition and Colon Cancer
F. Gastrointestinal Health and Disease
Intestinal Microflora and Diet in Health
Nutrition in Inflammatory Bowel Disease and Short Bowel Syndrome
Nutrient Considerations in Lactose Intolerance
Nutritional Considerations in the Management of Celiac Disease
Nutrition and Cystic Fibrosis
D. Bone Health and Disease
Current Understanding of Vitamin D Metabolism, Nutritional Status and Role in Disease Prevention
Osteoporosis: The Early Years
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From the Preface

The purpose of this text is to provide an update of current knowledge in clinical nutrition and an overview of the rationale and science base of its application to practice in the treatment and prevention of disease. The text addresses basic principles and concepts that are central to the major clinical nutrition-related activities, such as nutritional assessment and monitoring, current theoretical base and knowledge of efficacious interventions, interactions between genetic and nutritional factors, and the use and interpretation of population-based or clinical epidemiological evidence. The various roles of clinical nutrition and current knowledge of nutrition in the prevention and treatment of major disease-specific conditions are also reviewed, with an emphasis on past and current scientific evidence that supports these roles. New areas of interest and study are also discussed, with the perspective that the application of the scientific method is by definition an evolutionary process.

Treatment of the disease diabetes mellitus provides an excellent and current example of treatment evolution. In the early part of the 20th century, before the discovery of insulin by F.G. Banting and C.H. Best in 1921,the treatment of choice for individuals with diabetes mellitus was morphine for pain abatement along with a very restricted, starvation diet. When insulin injections became available, dietary protocols were developed. Initially, dietary treatment was based on food exchange lists that encouraged prescribed intakes of carbohydrate, protein, and fat. Recent research from the Diabetes Control and Complications Trial and a similar research trial inthe United Kingdom has been the base for the current dietary management emphasizing blood glucose monitoring throughout the day and individualized adjustment of carbohydrate ingestion and insulin injection in individuals who require insulin therapy. Nutrition intervention plays a major role in the management of the patient with diabetes mellitus and in the treatment of the disease and the prevention or delay of complications (see Part II.C).

Another essential role for nutrition intervention is in the prevention of cancer. Cancer represents a disease continuum and at all stages, from primary prevention to treatment, nutrition is a key factor. As discussed in the section highlighting nutrition and major cancer types, an explosion of new knowledge has identified nutrition as a major factor in the etiology and progression of disease (see Part II.B).

Nutrition is the process by which the human body utilizes food for the production of energy, for the maintenance of health, for growth, and for the normal functioning of every organ and tissue. Clinical nutrition is the study of nutrition and diet as related to the development and treatment of human disease. Nutrition is an interdisciplinary field of study, built on a foundation of biomedical and behavioral sciences. Clinical nutrition is the aspect of nutrition science that is related to the development, progression, or management of disease, as differentiated from the issues of normal requirements, cellular functions and activities, and various topics that must be addressed in meeting basic requirements to enable normal growth and development.

Areas of study that contribute to knowledge in clinical nutrition include the disease-relevant biochemistry, metabolism, and activities of nutrients and dietary factors within the tissues and cells; the bioavailability and utilization of nutrients from various food sources, as disease risk or diagnosis may influence these factors; the regulation and compartmentalization of nutrients in the body; the attitudes about food and the eating patterns and behaviors of the targeted individual or group; the technology of food science and specialized or modified food products; and the technology involved in providing adequate and appropriate nutrients or foods to individuals and various community-based or institutionalized groups. Other aspects of clinical nutrition include the development and evaluation of nutrition education efforts; the development of nutrition policies, guidelines, and practice standards that affect the goals and objectives of government and private health agencies, professional practice groups, and health-related organizations; and the design and implementation of individual, clinical, and community-based nutrition and diet interventions. Clinical nutrition interventions range in scope from efforts to maintain health during short-term illness, to optimization of health status in individuals at risk for or diagnosed with chronic diseases, to major nutritional and diet modifications as specific or adjuvant treatments for disease. Clinical nutrition encompasses primary, secondary, and tertiary disease prevention, in addition to management of disease.

Dietary intake or nutritional status may be altered as a result of disease or by the treatment modalities that are utilized, such as surgical treatments, or medical management strategies, such as drugs. The altered needs must be met by dietary or nutritional interventions in order to prevent malnutrition and the associated consequences, which would contribute to overall morbidity and mortality. Also, nutrition intervention can be a critical component of disease prevention, an important aspect of disease management, or the primary treatment for disease. A complicating factor is that people generally eat food, rather than nutrients, so that the practical and psychosocial aspects of diet modification and food or food product availability must be considered in any nutrition intervention, whether individual or community based, and irrespective of whether the goal is primary prevention or disease treatment.

As in any area of the biomedical sciences, the importance of science-based activities and practices cannot be understated. Clinical nutrition concepts and practices that can become popular with either the lay public or professionals are sometimes based on the type of scientific evidence that cannot truly support the rationales and practices, regardless of how standard and common they might be. Popular theories may be generated by observational epidemiological studies, case series, or anecdotal reports, all of which lack the capability of truly demonstrating a causative or efficacious role for the nutritional factor. Such studies are useful for generating hypotheses, but the apparent associations between diets and disease may be confounded by uncontrolled or unmeasured factors and other determinants of health and disease. Unproven diet therapies exist for the treatment of numerous conditions, and many aspects of common nutrition interventions are sorely in need of testing in an appropriate research design. As in any other aspect of disease prevention and treatment, the use of nutrition interventions or diet therapies should be based on a scientific rationale and sound data, not on anecdotal experience. The scientific basis for clinical nutrition needs to expand considerably in order to fully support claims for the efficacy of many of the common activities and interventions, and progress in this area is being made.

Our definitions of diseases need to further evolve to bring greater clarity and improve precision of treatment. As gene-diet interactions are scientifically delineated, laser-sharp therapies may be applied to specific individuals. For the public, however, generating and analyzing data that summarize dietary intake and its association with disease will be valuable tasks in both treating disease and developing disease prevention strategies. Well-designed focused screening will be an aid in disease detection, and well-founded medical nutrition therapies can minimize disease development and related complications. Providing scientifically sound, creative, and effective nutrition interventions can be challenging. In so doing, however, we will serve the public good. It is our goal to update our knowledge and its application through updated editions of this text. In addition, we plan to provide online access to relevant new findings and their import to nutrition in the prevention and treatment of disease. It is our goal to raise the bar for both understanding and treatment.

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