Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease

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Overview

The notion of matching diet with an individual’s genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health.

Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics—including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system.

Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

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Product Details

  • ISBN-13: 9781439844526
  • Publisher: CRC Press
  • Publication date: 12/26/2011
  • Pages: 448
  • Product dimensions: 7.10 (w) x 10.10 (h) x 1.10 (d)

Meet the Author

Dr. Bidlack received his Bachelor of Science degree in Dairy Science and Technology from the Pennsylvania State University (1966), his Master of Science degree in Food Science from Iowa State University (1968), and his Ph.D. Degree in Biochemistry from the University of California, Davis (1972). In addition, he was a postdoctoral fellow in Pharmacology at USC School of Medicine (1972-1974).

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Table of Contents

TRANSFORMING DIETARY SIGNALS INTO GENE EXPRESSION
Epigenetics: The Epigenetic Transfer of Phenotype
Epigenetics: Molecular Targets for Diet and Cancer Prevention, Sharon A. Ross
Diet-influenced Chromatin Modification and Expression of Chemopreventive Genes by the Soy Peptide, Lunasin, Alfredo F. Galvez, Liping Huang, Mark J.M. Magbanua, Kevin Dawson, Somen Nandi and Raymond L. Rodriguez
Role of Epigenetics in the Complications Associated with Diabetes and Related Metabolic Disorders, Louisa M. Villevenuve and Rama Natarajan
Systems Biology: Cell Signaling Regulation of Gene Expression
Systems Biology Approaches to Study Diet x Genome Interactions, Xia Yang, Zhidong Tu and Jun Zhu
Modulation of Atherosclerosis by N-3 Polyunsaturated Fatty Acids, Darshan S. Kelley, Yuriko Adkins, Sumeet Sharma, Dawn M. Fedor
Nutrigenomic Implications for Nuclear Receptor Coactivators, David M. Lonard and Bert W. O’Malley
Nutrigenomics of Fatty Acid Sensing, Sander Kersten
The Polyphenol Resveratrol Alters Global Patterns of Gene Regulation and Improves Physiology Through Multiple Potential Pathways, Behzad Varamini and Joseph A. Baur
Nutritional Genomics: Cellular Signaling and Molecular Targets, Wayne R. Bidlack
GENE LINKED NETWORKS
Gene Linked Chronic Disease
Mechanisms Mediating Obesity-Induced Inflammation and Insulin Resistance, Simon Schenk, Olivia Osborn and Jerrold M. Olefsky
Nutritional Genomics of Vitamin D on Cardiovascular Disease, Sandra F. Williams, Jorge N. Artaza and Keith C. Norris
Gene Linked Cancer Prevention
Network Analysis of Gene Expression Profiles in Breast Cancer Cell Lines, T. Gregory Dewey, Katie L. Streicher and Stephen P. Ethier
Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention, Ann M. Bode and Zigang Dong
Green Tea Polyphenols, DNA Repair and Prevention of Photocarcinogenesis, Santosh K. Katiyar
Bioactive Food Components and the "U" Shaped Health Conundrum: Vitamin D and Folate as Examples of Friends and Foes, John A. Milner
Intestinal Microbiome Linked Gene Expression
Human Intestinal Microbiome: Etiology of Inflammation Genomics, Roger A. Clemens
FOOD NEEDS TO MEET NUTRIGENOMIC HEALTH NEEDS
Agriculture’s Ability to Enhance Food Quality
Calcium Biofortification of Crops, Kendal D. Hirschi and Sean M. Thompson
The Use of Genomics-Aided Breeding to Improve the Nutritional Content of Lettuce, David W. Still
Food Science and Technology Enhancement of Diet quality
Natural Colorants as Bioactive Agents in Functional Foods, Ann Marie Craig
Manufacturing Functional Foods: Effects on Quality and Bioavailability, Ryan J. Elijas and John D. Floros
New Whole Foods Designed to Deliver Bioactive Components, Cheryl Mitchell
Regulatory Oversight
Nutritional Genomics and the Future of Food Labeling in the US, Evelyn D. Cadman
Index

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