Ocular Oncology / Edition 1

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Overview

Survival rates in cases of uveal melanoma and retinoblastoma—the leading intraocular malignancies in adults and children—may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger and promote the two most common ocular tumours.

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Product Details

  • ISBN-13: 9780824740160
  • Publisher: Taylor & Francis
  • Publication date: 8/26/2003
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 492
  • Product dimensions: 6.25 (w) x 9.25 (h) x 0.75 (d)

Table of Contents

Preface
Contributors
1 Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye 1
2 Clinical Overview: Retinoblastoma 19
3 Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements 35
4 Epidemiology of Retinoblastoma 47
5 Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis 63
6 Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma 81
7 A Cascade of Genomic Changes Leads to Retinoblastoma 103
8 The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma 129
9 Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitro 189
10 p53 and the Molecular Regulation of Cell Fate in Retinoblastoma 211
11 Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy 231
12 Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy 255
13 Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma 269
14 Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues 297
15 Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment 321
16 The Treatment of Retinoblastoma 353
17 Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors 377
18 Clinical Trials in Retinoblastoma 401
19 Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis 407
20 Retinoblastoma: Pathology and Prognosis 427
21 Molecular Genetics of Retinoblastoma 449
22 Genetically Engineered Mouse Models of Retinoblastoma 465
23 Treatment of Extraocular Retinoblastoma 489
Index 499
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