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Hopkins tells the story of Reuel Briggs, a medical student who couldn't care less about being black and appreciating African history, but finds himself in Ethiopia on an archeological trip. His motive is to raid the country of lost treasures -- which he does find in the ancient land. However, he discovers much more than he bargained for: the painful truth about blood, race, and the half of his history that was never told. Hopkins wrote the novel intending, in her own words, to "raise the stigma of degradation from [the Black] race." The title, Of One Blood, refers to the biological kinship of all human beings.