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Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Overview

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a ...

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Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

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Overview

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Key features:

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

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Editorial Reviews

From the Publisher
PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."—BRITISH MEDICAL JOURNAL
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Product Details

  • ISBN-13: 9780123945877
  • Publisher: Elsevier Science
  • Publication date: 3/14/2013
  • Pages: 488
  • Product dimensions: 6.30 (w) x 9.00 (h) x 1.10 (d)

Meet the Author

Terry P. Kenakin is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society. Having been involved in drug discovery for over 30 years, his interests include the optimal design of drug activity assays systems and quantitative drug receptor theory. He is a member of numerous editorial boards as well as Editor-in-Chief of the Journal of Receptors and Signal Transduction and Current Opinion in Pharmacology. In addition, Dr. Kenakin has authored numerous articles and has also written a number of books on pharmacology.

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Table of Contents

  1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
  2. Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

  3. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
  4. Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

  5. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
  6. Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

  7. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
  8. Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

  9. GPCRs in Stem Cell Function
  10. Van A. Doze and Dianne M. Perez

  11. Application of Receptor Theory to Allosteric Modulation of Receptors
  12. David A. Hall

  13. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
  14. Frederick J. Ehlert

  15. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
  16. Jesús Giraldo

  17. Chemokine Receptor Oligomerization and Allostery
  18. Bryan Stephens and Tracy M. Handel

  19. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac
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