Omega-3 Fatty Acids, the Brain and Retina

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Overview

"Research on omega-3 fatty acids has come a long way since its beginnings in the middle 70's. Starting with studies on the role of omega-3 fatty acids in the secondary prevention of cardiovascular disease, interest soon turned to the mechanisms of and the need to balance the omega-6 to the omega-3 ratio for homeostasis and normal development. Today, it is widely accepted that docosahexaenoic acid (DHA) and arachidonic acid are essential for brain development during pregnancy, lactation and throughout the life cycle. It is also no longer controversial that DHA can affect brain function, mental health and behavior, and studies on supplemental DHA in age-related macular degeneration have revealed significant Interactions between DHA and genetic variants." Featuring contributions by leading scientists in the field, this publication discusses not only the role of omega-3 fatty acids in maintaining homeostasis, but also their importance in the prevention and management of neurodegenerative diseases associated with the aging process or genetic predisposition. It is thus not only of interest to nutritionists, dieticians or policy makers, but also to psychologists, physiologists, neuroscientists, psychiatrists, ophthalmologists, geneticists, neurologists, pedlatrlclans, obstetricians and geriatricians.
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Product Details

Table of Contents

Preface A. P. Simopoulos Simopoulos, A. P.

Omega-6/Omega-3 Essential Fatty Acids: Biological Effects A. P. Simopoulos Simopoulos, A. P. 1

Depression, Suicide and Deficiencies of Omega-3 Essential Fatty Acids in Modern Diets J. R. Hibbeln Hibbeln, J. R. 17

Serial Structural MRI Analysis and Proton and [superscript 31]PMR Spectroscopy in the Investigation of Cerebral Fatty Acids in Major Depressive Disorder, Huntington's Disease, Myalgic Encephalomyelitis and in Forensic Schizophrenic Patients B. K. Puri Puri, B. K. S. Tsaluchidu Tsaluchidu, S. I. H. Treasaden Treasaden, I. H. 31

Omega-3 Fatty Acid Docosahexaenoic Acid Is the Precursor of Neuroprotectin D1 in the Nervous System T. D. Niemoller Niemoller, T. D. D. T. Stark Stark, D. T. N. G. Bazan Bazan, N. G. 46

Docosahexaenoic acid and Amyloid-[Beta] Peptide Signaling in Alzheimer's Disease W. J. Lukiw Lukiw, W. J. 55

Administration of Docosahexaenoic Acid, Uridine and Choline Increases Levels of Synaptic Membranes and Dendritic Spines in Rodent Brain R. J. Wurtman Wurtman, R. J. M. Cansev Cansev, M. T. Sakamoto Sakamoto, T. I. H. Ulus Ulus, I. H. 71

An Assessment of Dietary Docosahexaenoic Acid Requirements for Brain Accretion and Turnover during Early Childhood K. B. Hadley Hadley, K. B. A. S. Ryan Ryan, A. S. E. B. Nelson Nelson, E. B. N. Salem Salem, N. 97

Variation in Lipid-Associated Genes asThey Relate to Risk of Advanced Age-Related Macular Degeneration J. P. San Giovanni Giovanni, J. P. San S. Mehta Mehta, S. S. Mehta Mehta, S. 105

Author Index 159

Subject Index 160

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