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From The CriticsReviewer: Michael Easton, MD (Rush University Medical Center)
Description: This is an extensive review of the scientific research on opioid receptors and opioid receptor antagonists from theory to their applications and uses in various clinical conditions.
Purpose: This exceptional reference provides up-to-date reviews of the scientific literature and emerging data on the opioid-receptor system. It covers the basic science, including the molecular biology, biochemistry, anatomy, and pharmacology, and goes on to the clinical areas of behavioral neurosciences and psychiatric illnesses and how manipulation of this system affects various disorders.
Audience: This book is meant as a reference for both scientists and clinicians involved in the research or clinical application of opiate receptor antagonists.
Features: The history behind the development of the opioid antagonist naltrexone begins the book, which then goes on to review the characteristics of opioid receptors and describe the chemistry and pharmacology of opioid antagonists. It reviews the wide variety of clinical areas where these agents can be used: substance abuse (opiates, alcohol, nicotine and cannabis); behavioral disorders (appetite, eating disorders, mood disorders, pathological gambling, kleptomania, and self-injurious behavior); and other medical uses. The book finishes with a look at the development of innovative drug-delivery approaches being used with opioid antagonists.
Assessment: This is a comprehensive, detailed, and thorough reference on opiate receptors, opiate receptor antagonists, and the scientific data regarding their current use as well as potential clinical applications. The book also suggests future areas of research for the treatment of brain reward disorders as well as other medical indications where opioid receptor antagonists may be effective.