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From the Publisher"This unique book...bridges the gap between basic science andclinical electrophysiology."
William C. Roberts
American Journal of Cardiology
diac optical mapping. This is the first and only book to date that com prehensively, in a single volume, covers all aspects of the technique and application of optical mapping in the heart. Written by leading in ternational experts in the discipline, the book contains the basic pri nciples of optical mapping, including: voltage-sensitive fluorescence, optics, imaging, and high speed computer data acquisition. In additio n to providing a primer on basic principles, the book's four main sect ions cover applications of optical mapping to our understanding of imp ulse propagation in the heart, cardiac arrhythmias, and cardiac defibr illation. Commentary is provided throughout the book from leaders in t he field of clinical cardiac electrophysiology regarding implications to our understanding of arrhythmia mechanisms in patients. This book i s essential for scientists, cardiac clinicians, and trainees of all ba ckgrounds who are interested in state-of-the-art imaging approaches to biology, as well as for the investigator who is thinking about establ ishing an optical mapping system in his/her lab.
Mark E. Josephson.
Section I. Basic Principles .
Introduction: Optical Mapping of Cardiac Excitation andArrhythmias: A Primer.
David S. Rosenbaum.
1. Optical Mapping: Background and Historical Perspective.
2. Mechanisms and Principles of Voltage-SensitiveFluorescence.
Leslie M. Loew.
3. Optical Properties of Cardiac Tissue.
William T. Baxter.
4. Optics and Detectors Used in Optical Mapping.
Kenneth R. Laurita and Imad Libbus.
5. Optimization of Temporal Filtering for Optical TransmembranePotential Signals.
Francis X. Witkowski, Patricia A. Penkoske, and L. JoshuaLeon.
Section II. Microscopic Propagation.
Introduction: Unique Role of Optical Mapping in the Study ofPropagation and Repolarization.
David S. Rosenbaum.
6. Optical Mapping of Impulse Propagation withinCardiomyocytes.
7. Optical Mapping of Impulse Propagation betweenCardiomyocytes.
Stephan Rohr and Jan P. Kucera.
8. Role of Cell-to-Cell Coupling, Structural Discontinuities,and Tissue Anisotropy in Propagation of the Electrical Impulse.
André G. Kléber, Stephan Rohr, and Vladimir G.Fast.
9. Optical Mapping of Impulse Propagation in theAtrioventricular Node: 1.
Todor N. Mazgalev and Igor R. Efimov.
10. Optical Mapping of Impulse Propagation in theAtrioventricular Node: 2.
Guy Salama and Bum-Rak Choi.
11. Optical Mapping of Microscopic Propagation: ClinicalInsights and Applications.
Albert L. Waldo.
Section III. Cardiac Arrhythmias.
Introduction: Unique Role of Optical Mapping in the Study ofCardiac Arrhythmias.
12. Mapping Arrhythmia Substrates Related to Repolarization: 1.Dispersion of Repolarization.
Kenneth R. Laurita, Joseph M. Pastore, and David S.Rosenbaum.
13. Mapping Arrhythmia Substrates Related to Repolarization: 2.Cardiac Wavelength.
Steven Girouard and David S. Rosenbaum.
14. Video Imaging of Cardiac Fibrillation.
Richard A. Gray and José Jalife.
15. Video Mapping of Spiral Waves in the Heart.
William T. Baxter and Jorge M. Davidenko.
16. Video Imaging of Wave Propagation in a Transgenic MouseModel of Cardiomyopathy.
Faramarz Samie, Gregory E. Morley, Dhjananjay Vaidya, KarenL. Vikstrom, and José Jalife.
17. Optical Mapping of Cardiac Arrhythmias: Clinical Insightsand Applications.
Douglas L. Packer.
Section IV. Cardiac Defibrillation.
Introduction: Unique Role of Optical Mapping in the Study ofCardiac Defibrillation.
18. Response of Cardiac Myocytes to Electrical Fields.
19. New Perspectives in Electrophysiology from The CardiacBidomain.
Shien-Fong Lin and John P. Wikswo, Jr..
20. Mechanisms of Defibrillation: 1. Influence of FiberStructure on Tissue Response to Electrical Stimulation.
Stephen B. Knisley.
21. Mechanisms of Defibrillation: 2. Application of LaserScanning Technology.
Stephen M. Dillon.
22. Mechanisms of Defibrillation: 3. Virtual Electrode-InducedWave Fronts and Phase Singularities; Mechanisms of Success andFailure of Internal Defibrillation.
Igor R. Efimov and Yuanna Cheng.
23. Optical Mapping of Cardiac Defibrillation: Clinical Insightsand Applications.
Douglas P. Zipes.