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From the Publisher"This unique book...bridges the gap between basic science and clinical electrophysiology."
William C. Roberts
American Journal of Cardiology
The recent explosion of knowledge in the cardiovascular field has been fueled by the development of powerful and novel technologies for assessing cardiovascular function and disease. Fluorescent imaging techniques in the heart are a major example. Despite its widespread use in basic research and implications to clinical cardiac electrophysiology, there are no definitive and authoritative sources of information on cardiac optical mapping. This is the first and only book to date that comprehensively, in a single volume, covers all aspects of the technique and application of optical mapping in the heart. Written by leading international experts in the discipline, the book contains the basic principles of optical mapping, including: voltage-sensitive fluorescence, optics, imaging, and high speed computer data acquisition. In addition to providing a primer on basic principles, the book''s four main sections cover applications of optical mapping to our understanding of impulse propagation in the heart, cardiac arrhythmias, and cardiac defibrillation. Commentary is provided throughout the book from leaders in the field of clinical cardiac electrophysiology regarding implications to our understanding of arrhythmia mechanisms in patients. This book is essential for scientists, cardiac clinicians, and trainees of all backgrounds who are interested in state-of-the-art imaging approaches to biology, as well as for the investigator who is thinking about establishing an optical mapping system in his/her lab.
Mark E. Josephson.
Section I. Basic Principles .
Introduction: Optical Mapping of Cardiac Excitation and Arrhythmias: A Primer.
David S. Rosenbaum.
1. Optical Mapping: Background and Historical Perspective.
2. Mechanisms and Principles of Voltage-Sensitive Fluorescence.
Leslie M. Loew.
3. Optical Properties of Cardiac Tissue.
William T. Baxter.
4. Optics and Detectors Used in Optical Mapping.
Kenneth R. Laurita and Imad Libbus.
5. Optimization of Temporal Filtering for Optical Transmembrane Potential Signals.
Francis X. Witkowski, Patricia A. Penkoske, and L. Joshua Leon.
Section II. Microscopic Propagation.
Introduction: Unique Role of Optical Mapping in the Study of Propagation and Repolarization.
David S. Rosenbaum.
6. Optical Mapping of Impulse Propagation within Cardiomyocytes.
7. Optical Mapping of Impulse Propagation between Cardiomyocytes.
Stephan Rohr and Jan P. Kucera.
8. Role of Cell-to-Cell Coupling, Structural Discontinuities, and Tissue Anisotropy in Propagation of the Electrical Impulse.
André G. Kléber, Stephan Rohr, and Vladimir G. Fast.
9. Optical Mapping of Impulse Propagation in the Atrioventricular Node: 1.
Todor N. Mazgalev and Igor R. Efimov.
10. Optical Mapping of Impulse Propagation in the Atrioventricular Node: 2.
Guy Salama and Bum-Rak Choi.
11. Optical Mapping of Microscopic Propagation: Clinical Insights and Applications.
Albert L. Waldo.
Section III. Cardiac Arrhythmias.
Introduction: Unique Role of Optical Mapping in the Study of Cardiac Arrhythmias.
12. Mapping Arrhythmia Substrates Related to Repolarization: 1. Dispersion of Repolarization.
Kenneth R. Laurita, Joseph M. Pastore, and David S. Rosenbaum.
13. Mapping Arrhythmia Substrates Related to Repolarization: 2. Cardiac Wavelength.
Steven Girouard and David S. Rosenbaum.
14. Video Imaging of Cardiac Fibrillation.
Richard A. Gray and José Jalife.
15. Video Mapping of Spiral Waves in the Heart.
William T. Baxter and Jorge M. Davidenko.
16. Video Imaging of Wave Propagation in a Transgenic Mouse Model of Cardiomyopathy.
Faramarz Samie, Gregory E. Morley, Dhjananjay Vaidya, Karen L. Vikstrom, and José Jalife.
17. Optical Mapping of Cardiac Arrhythmias: Clinical Insights and Applications.
Douglas L. Packer.
Section IV. Cardiac Defibrillation.
Introduction: Unique Role of Optical Mapping in the Study of Cardiac Defibrillation.
18. Response of Cardiac Myocytes to Electrical Fields.
19. New Perspectives in Electrophysiology from The Cardiac Bidomain.
Shien-Fong Lin and John P. Wikswo, Jr..
20. Mechanisms of Defibrillation: 1. Influence of Fiber Structure on Tissue Response to Electrical Stimulation.
Stephen B. Knisley.
21. Mechanisms of Defibrillation: 2. Application of Laser Scanning Technology.
Stephen M. Dillon.
22. Mechanisms of Defibrillation: 3. Virtual Electrode-Induced Wave Fronts and Phase Singularities; Mechanisms of Success and Failure of Internal Defibrillation.
Igor R. Efimov and Yuanna Cheng.
23. Optical Mapping of Cardiac Defibrillation: Clinical Insights and Applications.
Douglas P. Zipes.