Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications [NOOK Book]

Overview

Understand and assess the design, delivery, and efficacy of orally administered drugs

A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with...

See more details below
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Available on NOOK devices and apps  
  • NOOK Devices
  • NOOK HD/HD+ Tablet
  • NOOK
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK Study
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
$91.99
BN.com price
(Save 42%)$160.95 List Price
Note: This NOOK Book can be purchased in bulk. Please email us for more information.

Overview

Understand and assess the design, delivery, and efficacy of orally administered drugs

A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.

The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen.

This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.

In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.

Read More Show Less

Editorial Reviews

From the Publisher
"This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery." (Fort Mill Times, 18 October 2011)
Read More Show Less

Product Details

  • ISBN-13: 9781118067581
  • Publisher: Wiley
  • Publication date: 8/4/2011
  • Series: Wiley Series in Drug Discovery and Development , #16
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 448
  • File size: 26 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Ming Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston. Dr. Hu is on the editorial boards of Molecular Pharmaceutics and the Journal of Alternative and Complementary Medicine.

Xiaoling Li, PhD, is Professor of Pharmaceutics and Associate Dean of Graduate Education and Research at the Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific. He is a Fellow of the American Association of Pharmaceutical Scientists.

Read More Show Less

Read an Excerpt

Click to read or download

Read More Show Less

Table of Contents

Foreword.

Preface.

Contributors.

Chapter 1. Barriers to Oral Bioavailability-An Overview (Ming Hu and Xiaoling Li).

Chapter 2. Physicochemical Characterization of Pharmaceutical Solids (Smita Debnath).

Chapter 3. Solubility of Pharmaceutical Solids (Lauren Wiser, Xiaoling Gao, Bhaskara Jasti, and Xiaoling Li).

Chapter 4. In Vitro Dissolution of Pharmaceutical Solids (Josephine L. P. Soh and Paul W. S. Heng).

Chapter 5. Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption (Paul C. Ho).

Chapter 6. Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways (Miki Susanto Park and Jae H. Chang).

Chapter 7. In vitro-In vivo Correlation of Pharmaceutical Dosage Forms (Deliang Zhou and Yihong Qiu).

Chapter 8. Drug Metabolism in Gastroinestinal Tract (Rashim Singh and Ming Hu).

Chapter 9. Efflux of Drugs via Transporters: The “Anti-absorption” Pathways (Jae H. Chang, James A. Uchizono and Miki Susanto Park).

Chapter 10. Liver Drug Metabolism (Leslie M. Tompkins, and Hongbing Wang).

Chapter 11. Protein Binding of Drugs (Antonia Kotsiou and Christine Tesseromatis).

Chapter 12. Urinary Excretion of Drugs and Drug Reabsorption (Pankaj Gupta, Bo Feng and Jack Cook).

Chapter 13. Pharmacokinetic Behaviors of Orally Administered Drugs (Jaime A. Yáñez, Dion R. Brocks, M. Laird Forrest, and Neal M. Davies).

Chapter 14. Effects of Food on Drug Absorption (Venugopal P. Marasanapalle, Xiaoling Li, and Bhaskara R. Jasti).

Chapter 15. Drug-Drug Interactions and Drug-Dietary Chemical Interactions (Ge Lin, Zhong Zuo, Na Li, and Li Zhang).

Chapter 16. Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rates, Dogs, and Humans (Ayman El-Kattan, Susan Hurst, Joanne Brodfuehrer, Cho-Ming Loi).

Chapter 17. Amino Acid Drug Transporters (Zhong Qiu Liu, and Ming Hu).

Chapter 18. Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide Based Pharmaceuticals (David J. Lindley, Stephen M. Carl, Dea Herrera-Ruiz, Li F. Pan, Lori B. Ward, Jonathan M. E. Goole, Olafur S. Gudmundsson, and Gregory T. Knipp).

Chapter 19. Organic Anion and Cation Drug Transporters (Takashi Sekine and Hiroshi Kusuhara).

Chapter 20. Gastroretentive Drug Delivery Systems (John R. Cardinal and Avinash Nangia).

Chapter 21. Lipid Based and self-emulsifying Oral Drug Delivery Systems (Sravan Penchala, Anh-Nhan Pham, Ying Huang and Jeffrey Wang).

Chapter 22. Prodrug Strategies to Enhance Oral Drug Absorption (Sai H.S. Boddu, Deep Kwatra, and Ashim K. Mitra).

Chapter 23. Oral Delivery of Protein/Peptide Therapeutics (Puchun Liu and Steven Dinh).

Chapter 24. ABC Transporters in Intestinal and Liver Efflux (Marilyn E. Morris and Yash A. Gandhi).

Chapter 25. Interplay between Efflux Transporter and Metabolic Enzymes (Stephen Wang).

Chapter 26. Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions (Yuanchao (Derek) Zhang, Lei Zhang, John M. Strong, Shiew-Mei Huang).

Chapter 27. Caco-2 Cell Culture Model for Oral Drug Absorption (Kaustubh Kulkarni and Ming Hu).

Chapter 28. MDCK Cells and Other Cell Culture Models of Oral Drug Absorption (Deep Kwatra, Sai H. S. Boddu, Ashim K. Mitra).

Chapter 29. Intestinal Perfusion Methods for Oral Drug Absorption (Wei Zhu and Eun-Jung (Zenobia) Jeong).

Chapter 30. Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion (Cindy Q. Xia, Chuang Lu, and Suresh K. Belan).

Chapter 31. In vivo Methods for Oral Bioavailability Studies (Ana Ruiz-Garcia and Marival Bermejo).

Chapter 32. Determination of Regulation of Drug Metabolizing Enzymes and Transporters (Bin Zhang and Wen Xie).

Chapter 33. Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction (Miguel Ángel Cabrera-Pérez, and Isabel González-Álvarez).

Index. 

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)