Organ Donation and Transplantation after Cardiac Death

Organ Donation and Transplantation after Cardiac Death

by David Talbot
     
 

ISBN-10: 0199217335

ISBN-13: 9780199217335

Pub. Date: 05/20/2009

Publisher: Oxford University Press, USA

With the success of organ transplantation and the declining number of heart beating cadaver doctors, the number of patients awaiting a transplant continues to rise. This means that alternative sources of donors have been sought, including donors after cardiac death. Such donors sustain rapid damage to their organs due to ischaemia, and as a consequence, some organs

Overview

With the success of organ transplantation and the declining number of heart beating cadaver doctors, the number of patients awaiting a transplant continues to rise. This means that alternative sources of donors have been sought, including donors after cardiac death. Such donors sustain rapid damage to their organs due to ischaemia, and as a consequence, some organs do not work initially and some none at all. The proportion of such transplants has increased dramatically in recent years—25% of kidney transplants in the UK were from such donors in 2006, highlighting how much progress has been made.

Written by international experts, this book lays out the moral, legal, and ethical restraints to using such donors for organ transplant together with the techniques that have been adpoted to improve their outcome. The different approaches and results of renal transplant according to country are covered together with the procedures and outcomes adopted to use other organs, notably the liver and lungs.

Product Details

ISBN-13:
9780199217335
Publisher:
Oxford University Press, USA
Publication date:
05/20/2009
Pages:
360
Product dimensions:
6.30(w) x 9.30(h) x 0.80(d)

Table of Contents

Contributors xi

1 History of non-heart-beating donation Gauke Kootstra 1

2 Legal, moral, and ethical issues Sam D. Shemie Michael De Vita 7

3 History of organ perfusion in organ transplantation Diethard Monbaliu Qiang Liu Katrien Vekemans Jacques Pirenne 31

4 Viability testing of kidneys from non-heart-beating donors David Talbot 51

5 Perfusate development for the NHBD Colin Wilson 67

6 Thrombolysis in the non-heart-beating donor David Talbot Mohamed Gok Thomas Minor 103

7 Supplemental cryopreservation of the donor by peritoneal cooling John Asher Alex Navarro 117

8 Gaseous oxygen to improve viability of marginal or pre-damaged organ grafts during hypothermic storage Thomas Minor 131

9 Extracorporeal circulatory-assisted non-heart-beating organ donation Jeff Punch 153

10 Patient selection and management Julio Pascual John D. Pirsch 161

11 The renal biopsy in non-heart-beating organ transplantation M. Snoeijs R. Matthijsen M.H. Christiaans J.P. van Hooff E. van Heurn W. Buurman R.J. van Suylen C.J. Peutz-Kootstra 173

12 Early results for renal transplants from non-heart-beating donors Alex Navarro 203

13 Liver transplantation using non-heart-beating donors Paolo Muiesan 213

14 Lung transplantation from non-heart-beating donors-donation after cardiac death (DCD) Chris Wigfield Robert Love John Dark 231

15 Donors without a heart beat in the United States Anthony D'Alessandro 255

16 Non-heart-beating donation in Europe Ernest van Heurn David Talbot 271

17 Renal and islet transplantation from non-heart-beating donors in Japan Hirofumi Noguchi Nobuyo Hatanaka Shinichi Matsumoto 289

18 The current situation and further development David Talbot AnthonyD'Alessandro 307

Index 313

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