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Organic Chem of Sugars

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More About This Textbook

Overview

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions.

Each chapter contains numerous examples demonstrating the methods and strategies that apply mainstream organic chemistry to the chemical modification of sugars. The book first describes the discovery, development, and impact of carbohydrates, followed by a discussion of protecting group strategies, glycosylation techniques, and oligosaccharide syntheses. Several chapters focus on reactions that convert sugars and carbohydrates to non-carbohydrate molecules including the substitution of sugar hydroxyl groups to new groups of synthetic or biological interest, cyclitols and carbasugars, as well as endocyclic heteroatom substitutions. Subsequent chapters demonstrate the use of sugars in chiral catalysis, their roles as convenient starting materials for complex syntheses involving multiple stereogenic centers, and syntheses for monosaccharides. The final chapters focus on new and emerging technologies, including approaches to combinatorial carbohydrate chemistry, the biological importance and chemical synthesis of glycopeptides, and the medicinally significant concept of glycomimetics.

Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, The Organic Chemistry of Sugars provides a comprehensive treatment of the manipulation of sugars and their importance in mainstream organic chemistry.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

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Product Details

  • ISBN-13: 9780824753559
  • Publisher: Taylor & Francis
  • Publication date: 9/28/2005
  • Edition description: New Edition
  • Pages: 904
  • Product dimensions: 7.00 (w) x 10.10 (h) x 2.10 (d)

Table of Contents

A DISCUSSION OF CARBOHYDRATE CHEMISTRY
An Historical Overview; R.J. Ferrier
Introduction to Carbohydrates; J. Kuszmann
Protective Group Strategies; S. Oscarson
Glycosylation Methods; P. Fügedi
Oligosaccharide Synthesis; P. Fügedi
FROM SUGARS TO SUGAR-LIKE STRUCTURES TO NON-SUGARS
Functionalization of Sugars; D.E. Levy
Strategies Towards C-Glycosides; D.E. Levy
From Sugars to Carba-Sugars; M. Sollogoub and P. Sinaÿ
Sugars with Endocyclic Heteroatoms Other than Oxygen; P. Greimel, J. Spreitz, F.K. Sprenger, A.E. Stütz, and T.M. Wrodnigg
SUGARS AS TOOLS, CHIRAL POOL STARTING MATERIALS AND FORMIDABLE SYNTHETIC TARGETS
Sugars as Chiral Auxiliaries; N. Pleuss, G. Zech, B. Furman, and H. Kunz
Sugars as Chiral Starting Materials in Enantiospecific Synthesis; Y. Chapleur and F. Chrétien
Synthesis of Carbohydrate Containing Complex Natural Compounds; K. Toshima
Total Asymmetric Synthesis of Monosaccharides and Analogs; P. Vogel ADDITIONAL TOPICS
Combinatorial Carbohydrate Chemistry; P. Arya and B. VNBS Sarma
Glycopeptides; M. Mogemark, J. Kihlberg
Carbohydrate Mimetics in Drug Discovery; O. Schwardt, H.C. Kolb, and B. Ernst

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