Organic Chemistry / Edition 5

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Loudon and Parise's Organic Chemistry is known for its clear writing, high standard of accuracy, and creative problems. This edition contains over 1,600 problems—many of them new and taken directly from the scientific literature. The book is used at a wide variety of schools, such as UC Berkeley, Caltech, Colorado, Cornell, Duke, Harvard, Illinois, Maryland, Purdue, Yale, Wisconsin, and many more. This edition provides students with more health examples drawn from modern medical practice, as well as many cutting-edge topics from modern synthetic organic chemistry. 
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Editorial Reviews

From the Publisher

“We have used a number of editions of Loudon for our second year organic course. Although each edition has represented a major advance in the presentation of new chemistry, they have all retained the lucid presentation and order of topics that attracted us to the first version. The problems and examples provide excellent reinforcement of the contents of each chapter. The inclusion of modern methodology in the newest edition will prepare students for graduate school and demonstrates the continuing evolution of organic chemistry.” —Robert H. Grubbs, California Institute of Technology
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Product Details

  • ISBN-13: 9780981519432
  • Publisher: Roberts and Company Publishers
  • Publication date: 1/5/2009
  • Edition description: Fifth edition
  • Edition number: 5
  • Pages: 1469
  • Sales rank: 121,166
  • Product dimensions: 8.40 (w) x 10.20 (h) x 1.90 (d)

Meet the Author

Marc Loudon is the Cwalina Distinguished Professor of Medicinal Chemistry at Purdue Univerity. His teaching awards include the Clark Teaching Prize (at Cornell), Purdue’s School of Pharmacy's Henry Heine Outstanding Teacher Award (1980 and 1985), the Class of 1922 Helping Students Learn Award, the Charles B. Murphy Award, membership in the Teaching Academy of Purdue and listing in Purdue’s permanent “Book of Great Teachers”, and designation as the Carnegie Foundation “Indiana Professor of the Year”. Most recently, Dr. Loudon has been involved in chemistry curriculum re-design for life-science majors and pre-health profession students with the NEXUS program of the Howard Hughes Medical Institute.

James Parise is a Teaching Professor in the Department of Chemistry and Biochemistry at the University of Notre Dame, where he lectures organic chemistry. Previously, he taught and coordinated organic chemistry laboratories at Duke University. Dr. Parise’s research interests include development of more effective teaching methods for large lecture courses and improving organic chemistry pedagogy in both the classroom and laboratory. He administers an instructor-training program in organic chemistry and is currently developing auxiliary courses aimed at supplementing student preparation for introductory organic courses.

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Table of Contents

1 What is organic chemistry? 1
Organic chemistry and this book 13
2 Organic structures 19
3 Determining organic structures 47
4 Structure of molecules 81
5 Organic reactions 113
6 Nucleophilic addition to the carbonyl group 135
7 Delocalization and conjugation 151
8 Acidity, basicity, and pK[subscript a] 181
9 Using organometallic reagents to make C-C bonds 209
10 Conjugate addition 227
11 Proton nuclear magnetic resonance 243
12 Nucleophilic substitution at the carbonyl (C=O) group 279
13 Equilibria, rates, and mechanisms: summary of mechanistic principles 305
14 Nucleophilic substitution at C=O with loss of carbonyl oxygen 339
15 Review of spectroscopic methods 361
16 Stereochemistry 381
17 Nucleophilic substitution at saturated carbon 407
18 Conformational analysis 447
19 Elimination reactions 477
20 Electrophilic addition to alkenes 503
21 Formation and reactions of enols and enolates 523
22 Electrophilic aromatic substitution 547
23 Electrophilic alkenes 581
24 Chemoselectivity: selective reactions and protection 615
25 Synthesis in action 643
26 Alkylation of enolates 663
27 Reactions of enolates with aldehydes and ketones: the aldol reaction 689
28 Acylation at carbon 723
29 Conjugate addition of enolates 749
30 Retrosynthetic analysis 771
31 Controlling the geometry of double bonds 803
32 Determination of stereochemistry by spectroscopic methods 823
33 Stereoselective reactions of cyclic compounds 851
34 Diastereoselectivity 881
35 Pericyclic reactions 1: cycloadditions 905
36 Pericyclic reactions 2: sigmatropic and electrocyclic reactions 943
37 Rearrangements 969
38 Fragmentation 1003
39 Radical reactions 1021
40 Synthesis and reactions of carbenes 1053
41 Determining reaction mechanisms 1079
42 Saturated heterocycles and stereoelectronics 1121
43 Aromatic heterocycles 1: structures and reactions 1147
44 Aromatic heterocycles 2: synthesis 1185
45 Asymmetric synthesis 1219
46 Organo-main-group chemistry 1: sulfur 1247
47 Organo-main-group chemistry 2: boron, silicon, and tin 1277
48 Organometallic chemistry 1311
49 The chemistry of life 1345
50 Mechanisms in biological chemistry 1381
51 Natural products 1413
52 Polymerization 1451
53 Organic chemistry today 1481
Index 1491
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