The Organic Chemistry of Drug Design and Drug Action / Edition 2

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Overview

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand.

* Organic chemist's perspective of how drugs are designed and function
* Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples
* Extensive use of references to the primary and secondary literature for more in depth reading about all concepts
* Extensive use of structures, schemes, and figures to illustrate points
* Explanations of dual-acting drugs
* Problem sets and answers for each topic
* Casual writing style
* Author has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.

Audience: Advanced undergraduate and graduate students in organic-bioorganic and medicinal chemistry. Synthetic organic chemists. Practicing chemists in these fields working in the area of drug discovery and development.

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Editorial Reviews

From the Publisher
"Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development."
-Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004

"What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs."
-ORGANIC CHEMISTRY ORG., 2005

Praise for the New Edition:
"...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry."

--JOURNAL OF MEDICINAL CHEMISTRY

Praise for the First Edition:
"This book is a tour de force...appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

"... unified, well-organized and clearly presented...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data ..."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION

"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..."
--William C. Groutas, Wichita State University

"...The organization of this book and the clarity of presentation are outstanding...It is highly recommended..."
--JOURNAL OF MEDICINAL CHEMISTRY

Booknews
A textbook for a semester course in medicinal chemistry for senior or first-year graduate students of chemistry or biochemistry. Approaches the subject, not from the usual perspective of classes of drugs, but by the organic chemical mechanisms and effect desired when designing new drugs. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780126437324
  • Publisher: Elsevier Science
  • Publication date: 1/26/2004
  • Edition description: REV
  • Edition number: 2
  • Pages: 617
  • Sales rank: 816,692
  • Product dimensions: 7.20 (w) x 10.30 (h) x 1.60 (d)

Meet the Author

Professor Silverman has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry. He has been awarded 21 patents and is currently under consideration for the commercialization of a newly invented drug.
Professor Silverman has an extensive track record in the field of medicinal chemistry and has taught from this text to students of all levels for over ten years.
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Read an Excerpt

The long-awaited revision of this classic bestseller!
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Table of Contents

PREFACE CHAPTER 1 -- Introduction CHAPTER 2 -- Drug Discovery, Design, and Development CHAPTER 3 -- Receptors CHAPTER 4 -- Enzymes (Catalytic Receptors)
CHAPTER 5 -- Enzyme Inhibition and Inactivation CHAPTER 6 -- DNA-Interactive Agents CHAPTER 7 -- Drug Metabolism CHAPTER 8 -- Prodrugs and Drug Delivery Systems INDEX
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