The Organic Chemistry of Drug Synthesis / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $98.05
Usually ships in 1-2 business days
(Save 43%)
Other sellers (Hardcover)
  • All (10) from $98.05   
  • New (8) from $131.06   
  • Used (2) from $98.05   


The classic reference on the synthesis of medicinal agents —now completely updated

The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6.Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered.

As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

Read More Show Less

Editorial Reviews

From the Publisher
"The book is up-to-date with regard to the drugs presented and has the potential to be a good resources for experienced researchers in drug design…" (Journal of the American Chemical Society, March 12, 2008)
The series meets the needs of practitioners in the field who seek a quick overview of the synthetic routes that have been used to access specific classes of therapeutic agents. Volume 5 covers the literature on the synthesis of medicinal agents from 1988 to 1993. The materials are arranged and discussed in terms of chemical structure; thus, the preparation and detailed organic chemistry of the classes are presented in a unified way. Only drugs which have been granted a US Adopted Name are included. For synthetic organic, pharmaceutical, medicinal, and heterocyclic chemists. Annotation c. Book News, Inc., Portland, OR (
Read More Show Less

Product Details

Meet the Author

Daniel Lednicer, PhD, is the author of several books on drug synthesis and discovery. His career in both the private and public sectors has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.

Read More Show Less

Table of Contents

Preface     xi
Open-Chain Compounds     1
Peptidomimetic Compounds     2
Antiviral Protease Inhibitors     2
Human Immunodeficiency Virus     2
Human Rhinovirus j     9
Miscellaneous Peptidomimetic Compounds     11
References     19
Alicyclic Compounds     21
Monocyclic Compounds     21
Prostaglandins     21
Antiviral Agents     25
Miscellaneous Monocyclic Compounds     29
Polycyclic Compounds: Steroids     31
19-Nor Steroids     31
Corticosteroid Related Compounds     34
Polycyclic Compounds /     38
References     40
Monocyclic Aromatic Compounds     43
Arylcarbonyl Derivatives     43
Biphenyls     47
Compounds Related to Aniline     50
Compounds Related to Arylsulfonic Acids     53
Diarylmethanes     58
Miscellaneous Monocyclic Aromatic Compounds     60
References     67
Carbocyclic Compounds Fused to a Benzene Ring     69
Indenes     69
Naphthalenes     73
Tetrahydronaphthalenes     74
Other benzofused carbocyclic compounds     79
References     81
Five-Membered Heterocycles     83
Compounds with One Heteroatom     83
Compounds with Two Heteroatoms     91
Oxazole and Isoxazoles     91
Imidazoles and a Pyrrazole     94
Thiazoles     99
Triazoles     103
Tetrazoles     109
References     112
Six-Membered Heterocycles     115
Compounds with One Heteroatom     115
Pyridines     115
Reduced Pyridines     117
Miscellaneous     119
Compounds with Two Heteroatoms     121
Pyrimidines     121
Miscellaneous Six-Membered Heterocycles     133
References     136
Five-Membered Heterocycles Fused to One Benzene Ring     139
Compounds with One Heteroatom     139
Benzofurans     139
Indoles     141
Indolones     148
Miscellaneous Compounds with One Heteroatom     153
Five-Membered Rings with Two Heterocyclic Atoms     156
Benzimidazoles     156
Miscellaneous Compounds      158
References     160
Six-Membered Heterocycles Fused to One Benzene Ring     163
Compounds with One Heteroatom     163
Benzopyrans     163
Quinolines and Their Derivatives     167
Quinolone Antibacterial Agents     172
Compounds with Two Heteroatoms     176
Benzoxazines     176
Quinazolines     178
Miscellaneous Benzo-Fused Heterocycles     184
References     186
Bicyclic Fused Heterocycles     189
Compounds with Five-Membered Rings Fused to Six-Membered Rings     189
Compounds with Two Heteroatoms     189
Compounds with Three Heteroatoms     191
Compounds with Four Heteroatoms     195
Compounds with Two Fused Six-Membered Rings     208
Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams     213
References     215
Polycyclic Fused Heterocycles     217
Compounds with Three Fused Rings     217
Compounds with Four Fused Rings     228
Compounds with Five or More Fused Rings: Camptothecins     230
References     232
Subject Index     233
Cross Index of Biological Activity      241
Cumulative Index     245
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)