The Organic Chemistry of Enzyme-Catalyzed Reactions / Edition 1

The Organic Chemistry of Enzyme-Catalyzed Reactions / Edition 1

by Richard B. Silverman
     
 

ISBN-10: 0126437459

ISBN-13: 9780126437454

Pub. Date: 12/28/1999

Publisher: Elsevier Science & Technology Books

This unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Illustrated with a vast number of computer-drawn structures and reaction schemes, each chapter describes the organic reaction mechanisms that enzymes use to catalyze a particular family of organic transformations. Rather than…  See more details below

Overview

This unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Illustrated with a vast number of computer-drawn structures and reaction schemes, each chapter describes the organic reaction mechanisms that enzymes use to catalyze a particular family of organic transformations. Rather than bogging the reader down with all of the enzymes that catalyze a transformation, Professor Silverman selects one or two examples of enzymes that catalyze the particular chemistry. Chemical model studies used to elucidate enzyme mechanisms are discussed, along with the design of haptens, the generation of catalytic antibodies ("designer enzymes"), and the design and mechanism of enzyme inhibitors. An extensive bibliography annotates the coverage of numerous experiments that aid in elucidating of the enzyme mechanisms. Problem sets and solutions are provided for each chapter. Intended as a textbook for courses in enzymology and bioorganic and medicinal chemistry, The Organic Chemistry of Enzyme-Catalyzed Reactions will also serve as an essential reference for chemists and biochemists working with enzymes in the chemical, pharmaceutical, agricultural, and biotechnology industries.

KEY FEATURES

· Shows how enzyme-catalyzed reactions are simply efficient organic reactions
· Emphasizes the connection between organic reaction mechanisms and enzyme mechanisms
· Explains how enzymes can accelerate the rates of chemical reactions with high specificity
· Uses selected enzymes to demonstrate general mechanisms of enzyme-catalyzed reactions
· Compiles the latest information about molecular mechanisms of enzyme reactions
· Illustrated with a vast array of clearly drawn structures, schemes, and figures
· Includes an extensive bibliography on enzyme mechanisms
· Describes approaches to the design of enzyme inhibitors
· Covers catalytic antibody design and mechanisms
· Provides problem sets and solutions for each chapter
· Written in an informal and engaging style

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Product Details

ISBN-13:
9780126437454
Publisher:
Elsevier Science & Technology Books
Publication date:
12/28/1999
Edition description:
New Edition
Pages:
718
Product dimensions:
6.39(w) x 9.35(h) x 1.44(d)

Table of Contents

Preface
About the Author
1Enzymes as Catalysts
2Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
3Reduction and Oxidation
4Monooxygenation
5Dioxygenation
6Substitutions
7Carboxylations
8Decarboxylation
9Isomerizations
10Eliminations and Additions
11Aldol and Claisen Reactions and Retroreactions
12Formylations, Hydroxymethylations, and Methylations
13Rearrangements
App. IEnzyme Kinetics
App. II: Problems and Solutions
Index

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