Organic Chemistry / Edition 7

Organic Chemistry / Edition 7

by T. W. Graham Solomons, Craig B. Fryhle
     
 

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ISBN-10: 047141803X

ISBN-13: 9780471418030

Pub. Date: 06/01/2001

Publisher: Wiley

On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest.

The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however.
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Overview

On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest.

The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however.
A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand.

This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!

Product Details

ISBN-13:
9780471418030
Publisher:
Wiley
Publication date:
06/01/2001
Edition description:
7th Edition Upgrade
Pages:
1368
Product dimensions:
8.43(w) x 10.35(h) x 1.92(d)

Related Subjects

Table of Contents

Chapter 1. Carbon Compounds and Chemical Bonds
Chapter 2. Representative Carbon Compounds: Functional Groups, Intermolecular Forces, and Infrared (IR) Spectroscopy
Chapter 3. An Introduction to Organic Reactions: Acids and Bases
Chapter 4. Alkanes: Nomenclature, Conformational Analysis, and an Introduction to Synthesis
Chapter 5. Stereochemistry: Chiral Molecules
Chapter 6. Ionic Reactions—Nucleophilic Substitution and Elimination Reactions of Alkyl Halides
Chapter 7. Alkenes and Alkynes I: Properties and Synthesis, Elimination Reactions of Alkyl Halides
Chapter 8. Alkenes and Alkynes II: Addition Reactions
Chapter 9. Nuclear Magnetic Resonance and Mass Spectrometry: Tools for Structure Determination
Chapter 10. Radical Reactions
Chapter 11. Alcohols and Ethers
Chapter 12. Alcohols from Carbonyl Compounds. Oxidation-Reduction and Organometallic Compounds
Chapter 13. Conjugated Unsaturated Syste\ms
Chapter 14. Aromatic Compounds
Chapter 15. Reactions of Aromatic Compounds
Chapter 16. Aldehydes and Ketones I: Nucleophilic Addition to the Carbonyl Group
Chapter 17. Aldehydes and Ketones II: Aldol Reactions
Chapter 18. Carboxylic Acids and Their Derivatives. Nucleophilic Addition-Elimination at the Acyl Carbon
Chapter 19. Synthesis and Reactions of ß-Dicarbonyl Compounds: More Chemistry of Enolate Anions
Chapter 20. Amines
Chapter 21. Phenols and Aryl Halides: Nucleophilic Aromatic Sunstitution
Chapter 22. Carbohydrates
Chapter 23. Lipids
Chapter 24. Amino Acids and Proteins
Chapter 25. Nucleic Acids and Protein Synthesis
Answers to Selected Problems
Glossary
Illustration and PhotoCredits
Index
Appendix A. Upgrade Edition Additional Problems
Appendix B. Answers to Upgrade Edition Additional Problems.

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