Organic Chemistry / Edition 7

Organic Chemistry / Edition 7

by T. W. Graham Solomons, Craig B. Fryhle
     
 

ISBN-10: 047141803X

ISBN-13: 9780471418030

Pub. Date: 06/01/2001

Publisher: Wiley

On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest.

The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however.
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Overview

On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest.

The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however.
A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand.

This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!

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Product Details

ISBN-13:
9780471418030
Publisher:
Wiley
Publication date:
06/01/2001
Edition description:
7th Edition Upgrade
Pages:
1368
Product dimensions:
8.43(w) x 10.35(h) x 1.92(d)

Related Subjects

Table of Contents

Ch. 1Carbon Compounds and Chemical Bonds1
Ch. 2Representative Carbon Compounds: Functional Groups, Intermolecular Forces, and Infrared (IR) Spectroscopy52
Ch. 3An Introduction to Organic Reactions: Acids and Bases94
Ch. 4Alkanes: Nomenclature, Conformational Analysis, and an Introduction to Synthesis134
Ch. 5Stereochemistry: Chiral Molecules193
Ch. 6Ionic Reactions - Nucleophilic Substitution and Elimination Reactions of Alkyl Halides238
Ch. 7Alkenes and Alkynes I: Properties and Synthesis, Elimination Reactions of Alkyl Halides287
Ch. 8Alkenes and Alkynes II: Addition Reactions328
Ch. 9Nuclear Magnetic Resonance and Mass Spectrometry: Tools for Structure Determination383
Ch. 10Radical Reactions447
Ch. 11Alcohols and Ethers492
Ch. 12Alcohols from Carbonyl Compounds. Oxidation-Reduction and Organometallic Compounds537
Ch. 13Conjugated Unsaturated Systems577
Ch. 14Aromatic Compounds622
Ch. 15Reactions of Aromatic Compounds664
Ch. 16Aldehydes and Ketones I. Nucleophilic Addition to the Carbonyl Group716
Ch. 17Aldehydes and Ketones II. Aldol Reactions769
Ch. 18Carboxylic Acids and Their Derivatives. Nucleophilic Addition - Elimination at the Acyl Carbon813
Ch. 19Synthesis and Reactions of [Beta]-Dicarbonyl Compounds: More Chemistry of Enolate Ions878
Ch. 20Amines840
Ch. 21Phenols and Aryl Halides: Nucleophilic Aromatic Substitution1000
Ch. 22Carbohydrates1072
Ch. 23Lipids1128
Ch. 24Amino Acids and Proteins1166
Ch. 25Nucleic Acids and Protein Synthesis1220
Answers to Selected Problems
Glossary
Photo and Illustration Credits
Index

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