Organometallics in Process Chemistry / Edition 1

Organometallics in Process Chemistry / Edition 1

by Rob Larsen
     
 

The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important

See more details below

Overview

The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.

Read More

Product Details

ISBN-13:
9783642056871
Publisher:
Springer Berlin Heidelberg
Publication date:
12/15/2010
Series:
Topics in Organometallic Chemistry Series, #6
Edition description:
Softcover reprint of the original 1st ed. 2004
Pages:
286
Product dimensions:
9.21(w) x 6.14(h) x 0.65(d)

Table of Contents

G.G. Wu, M. Huang: Organolithium in Asymmetric Processes.- D.L. Hughes: Applications of Organotitanium Reagents.- K. Sumi, H. Kumobayashi: Rhodium/Ruthenium Applications.- A.J. Delmonte, E.D. Dowdy and D.J. Watson: Development of Transition Metal-Mediated Cyclopropanation Reactions.- J.F. Larrow, E.N. Jacobsen: Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes.- S.J. Mehrman, A.F. Abdel-Magid, C.A. Maryanoff and B.P. Medaer: Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances.- M. Prashad: Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients.- A.O. King, N. Yasuda: Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals.- J. Kant: Stereospecific Introduction of Cephalosporin Side Chains Employing Transition Metal Complexes.- J.T. Bien, G.C. Lane and M.R. Oberholzer: Removal of Metals from Process Streams: Methodologies and Applications

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >