Osteoporosis

by Robert Marcus MD (Editor), David Feldman (Editor), Dorothy Nelson (Editor), Clifford Rosen (Editor)

Overview

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

NEW TO THIS EDITION:*Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

Product Details

ISBN-13:	9780080553474
Publisher:	Elsevier Science
Publication date:	11/08/2007
Sold by:	Barnes & Noble
Format:	eBook
Pages:	2016
File size:	45 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education,&Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly&Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone&Mineral Research in 2000-2001.
Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Table of Contents

Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
Understanding of Osteoporosis
Basic Science/Bone Biology
Osteoblast Biology
Osteoclast Biology
Osteocytes
The Regulatory Role of Matrix Proteins in Mineralization of Bone
Development of the Skeleton
Mouse Genetics as a Tool to Study Bone Development and Physiology
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens and Skeletal Biology: Basic Mechanisms
Phosphatonins
Wnt Signaling in Bone
Cytokines and Bone Remodeling
Skeletal Growth Factors
Intercellular Communication During Bone Remodeling
Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth, Aging and Disease
Inhibition of Osteoporosis by Biophysical Intervention
Biomechanics of Age-Related Fractures
Bone Quality
Epidemiology&Risk Factors
Epidemiologic Methods in Studies of Osteoporosis
Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Bone Acquisition in Adolescence
Genetic Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prevention of Osteoporosis and Associated Fractures
Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis
Non-Skeletal Risk Factors for Osteoporosis and Fractures
Falls as Risk Factors for Fracture
Assessment of Fracture Risk
Outcomes of Osteoporotic Fractures
Pathophysiology
Local and Systemic Factors in the Pathogenesis of Osteoporosis
Animal Models for Osteoporosis
Estrogen, Bone Homeostasis and Osteoporosis
Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
Osteoporosis in Childhood and Adolescence
Glucocorticoid-Induced Osteoporosis
Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach
Mechanisms of Immobilization-induced Bone Loss
Leptin-Dependent Regulation of Bone Mass
Thyroid Hormone and the Skeleton
Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease
The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis
Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
Osteoporosis Associated with Illnesses and Medications
Transplantation Osteoporosis
Osteoporosis Associated with Cancer Therapy
Osteoporosis Associated with Pregnancy
Osteoporosis Associated with Rheumatologic Disease
Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks
Localized Osteoporosis
Evaluation and Management
Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
Who Should be Screened: Who Should be Treated?
Radiology of Osteoporosis
Clinical Use of Bone Densitometry
Biochemical Markers of Bone Turnover in Osteoporosis
The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis
An Orthopedic Perspective of Osteoporosis
Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs
Pharmacology and Therapeutics
Design Considerations for Clinical Investigations of Osteoporosis
Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials
Evidence-Based Osteoporosis Care
The Role of Calcium in the Treatment of Osteoporosis
Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis
Estrogen Therapy: Prevention and Treatment of Osteoporosis
Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens
Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis
Calcitonin in Osteoporosis
Strontium Therapy for Osteoporosis
Androgens
Treatment with PTH Peptides
Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
New approaches to Osteoporosis Therapeutics

What People are Saying About This

From the Publisher

This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment.

Editorial Reviews

5 Stars! from Doody

This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics. "The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management. "It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly. "The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available. "This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensiveand stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.

Melissa Cavaghan

Once a curiosity to a few endocrinologists or rheumatologists, osteoporosis has become (during the past two decades) a major focus of investigators and clinicians in fields as diverse as mechanical engineering, pediatrics, and epidemiology. In this hefty reference, 70 contributions cover all aspects of the subject, including the effects of numerous genetic and environmental factors, structural and biomechanical underpinnings, ethnoepidemiology, cellular mechanisms, radiologic assessment, clinical descriptions, and therapeutics. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Praise for Previous Editions:
"...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here..."
-THE NEW ENGLAND JOURNAL OF MEDICINE

From the Publisher

Reviewer: Melissa K. Cavaghan, MD (Indiana University School of Medicine)
Description: This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics.
Purpose: The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management.
Audience: It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly.
Features: The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available.
Assessment: This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensive and stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.

Doody's Review Service