Osteoporosis

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This book offers a comprehensive, authoritative reference on osteoporosis, covering all aspects of the disease, from basic biology, anatomy, physiology, and pathophysiology to preclinical issues, experimental medicine, management, and therapeutics.

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Overview

This book offers a comprehensive, authoritative reference on osteoporosis, covering all aspects of the disease, from basic biology, anatomy, physiology, and pathophysiology to preclinical issues, experimental medicine, management, and therapeutics.

Audience: Researchers, academic clinicians, and libraries.

Read More Show Less

Editorial Reviews

Melissa Cavaghan
This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics. "The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management. "It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly. "The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available. "This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensiveand stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.
Booknews
Once a curiosity to a few endocrinologists or rheumatologists, osteoporosis has become (during the past two decades) a major focus of investigators and clinicians in fields as diverse as mechanical engineering, pediatrics, and epidemiology. In this hefty reference, 70 contributions cover all aspects of the subject, including the effects of numerous genetic and environmental factors, structural and biomechanical underpinnings, ethnoepidemiology, cellular mechanisms, radiologic assessment, clinical descriptions, and therapeutics. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Melissa K. Cavaghan, MD (Indiana University School of Medicine)
Description: This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics.
Purpose: The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management.
Audience: It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly.
Features: The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available.
Assessment: This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensive and stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.
From the Publisher
Praise for Previous Editions:
"...interesting, comprehensive and up-to-date: each chapter has something new and important to say..."
-JOURNAL OF BONE AND JOINT SURGERY

"...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here..."
-THE NEW ENGLAND JOURNAL OF MEDICINE


5 Stars! from Doody
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Product Details

  • ISBN-13: 9780124708648
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 12/31/2000
  • Edition number: 2
  • Pages: 829

Meet the Author

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

David W. Dempster, PhD, is Professor of Clinical Pathology and Cell Biology at Columbia University in New York. He obtained his PhD from the University of Glasgow in Scotland and completed postdoctoral studies in Switzerland and France. Dr. Dempster is a Past President of the International Society of Bone Morphometry and a member of the Scientific Advisory Council of the National Osteoporosis Foundation. He is also a Fellow of the Royal Microscopical Society. Dr. Dempster’s iconic micrographs of osteoporotic bone have been widely reproduced in the scientific and popular press, including being displayed at the Smithsonian Institution in Washington, DC. Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of the Journal of Bone and Mineral Research, Bone and the Journal of Clinical Densitometry. His research studies have been continuously supported by the National Institutes of Health for the past 25 years. Dr. Dempster has published over 200 research papers on the pathophysiology and treatment of bone disese.

Marjorie M. Luckey, MD is Medical Director of the Osteoporosis and Metabolic Bone Disease Center at the Saint Barnabas Medical Center in Livingston, NJ. She holds board certifications in Internal Medicine and Endocrinology and Metabolism and has been actively engaged in bone disease research, education, and patient care since 1982. As Associate Professor of Reproductive Science at Mount Sinai Medical Center in New York, New York, her independent research and publications included NIH-supported studies of bone health and calcium metabolism in African-American women; studies on the effects of organ transplantation, genetic diseases, and primary biliary cirrhosis on bone health; and investigations into laboratory testing in osteoporotic women. In addition, she has participated in many multinational trials of new therapeutic agents for osteoporosis.

Dr. Luckey is Chair of the Better Bones Project, a national education program designed to teach primary care physicians how to evaluate and treat osteoporosis. She is on the editorial board of the Journal of Clinical Densitometry, on the Scientific Advisory Council of the National Osteoporosis Foundation and is a member of the Bone Densitometry Certification Faculty for the International Society for Clinical Densitometry. She has also served on the Board of Directors of the International Society for Clinical Densitometry, the Practice Committee for The American Society of Bone and Mineral Research, and the National Bone Health Campaign Scientific Task Force for the Centers for Disease Control and Prevention.

Dr. Cauley is Professor and Vice Chair for Research, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (Pennsylvania). Her primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in menopause and the multiple physiological, social, pathological changes that occur during this time. Her research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. Her work has focused on use of hormone therapy, osteoporosis, risk of hip fractures and bone density in midlife women to older women.
She is the Principal Investigator (PI) of several large cohort studies including the Study of Osteoporotic Fracture (SOF) and the Osteoporotic Fracture Risk in Men Study (MrOS). Results from both of these studies have made major improvements in our understanding of osteoporosis in older men and women. Dr. Cauley was Co-PI for the Women's Health Initiative (WHI) and served as study wide Chair of the Osteoporosis, Calcium and Vitamin D Committee for almost the entire duration of the trial. She is a Co-investigator for the Study of Women's Health Across the Nation (SWAN) with particular emphases on skeletal health and physical function and body composition changes as women transition from midlife to elder status. She is also a PI of a SWAN ancillary study examining novel measures of hip strength. She has participated as a clinical center PI for major randomized clinical trials including the Fracture Intervention Trial, the Multiple Outcomes of Raloxifene Evaluation, the Heart Estrogen/Progestin Study, the HORIZON Pivotal Fracture Trial and the Testosterone Trial. She has published over 570 original research articles.

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Table of Contents

Contributors
Preface
Ch. 1 The Bone Organ Systems: Form and Function
Ch. 2 Osteoblast Biology
Ch. 3 Osteoclast Biology
Ch. 4 The Biochemistry of Bone
Ch. 5 Peptide Hormones Acting on Bone
Ch. 6 Vitamin D: Metabolism and Action
Ch. 7 Regulation of Bone Cell Function by Gonadal Steroids
Ch. 8 Skeletal Growth Factors
Ch. 9 Bone Morphogenetic Proteins: Potential Role in Osteoporosis
Ch. 10 Coupling of Bone Resorption and Formation during Bone Remodeling
Ch. 11 Cytokines and Bone Remodeling
Ch. 12 Skeletal Heterogeneity and the Purpose of Bone Remodeling: Implications for the Understanding of Osteoporosis
Ch. 13 Skeletal Development: Mechanical Consequences of Growth, Aging, and Disease
Ch. 14 Inhibition of Osteopenia by Biophysical Intervention
Ch. 15 Biomechanics of Age-Related Fractures
Ch. 16 Introduction to Epidemiologic Methods
Ch. 17 Magnitude and Impact of Osteoporosis and Fractures
Ch. 18 Race, Ethnicity, and Osteoporosis
Ch. 19 Bone Mineral Acquisition in Utero and during Infancy and Childhood
Ch. 20 Bone Acquisition in Adolescence
Ch. 21 Genetic Determinants of Bone Mass
Ch. 22 Nutrition and Risk for Osteoporosis
Ch. 23 Physical Activity and Risk for Osteoporosis
Ch. 24 Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis
Ch. 25 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of Osteoporosis
Ch. 26 The Effects of Tobacco and Alcohol Use on Bone
Ch. 27 Falls as Risk Factors for Fractures
Ch. 28 What Is a Vertebral Fracture?
Ch. 29 Assessing Fracture Risk
Ch. 30 Outcomes of Osteoporotic Fractures
Ch. 31 The Nature of Osteoporosis
Ch. 32 Interaction of Local and Systemic Factors in the Pathogenesis of Osteoporosis
Ch. 33 Animal Models for in Vivo Experimentation in Osteoporosis Research
Ch. 34 The Type I/Type II Model for Involutional Osteoporosis
Ch. 35 Bone Remodeling Abnormalities in Osteoporosis
Ch. 36 The Role of Parathyroid Hormone and Vitamin D in the Pathogenesis of Osteoporosis
Ch. 37 Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
Ch. 38 Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
Ch. 39 Osteopenia in Childhood and Adolescence
Ch. 40 Glucocorticoid-Induced Osteoporosis
Ch. 41 Familial Osteoporosis
Ch. 42 Immobilization Osteopenia
Ch. 43 Thyroid Hormone and the Skeleton
Ch. 44 Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Diseases
Ch. 45 Primary Hyperparathyroidism, Hyperparathyroid Bone Disease, and Osteoporosis
Ch. 46 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
Ch. 47 Osteoporosis Associated with Illness and Medications
Ch. 48 Transplantation Osteoporosis
Ch. 49 Osteoporosis Associated with Pregnancy
Ch. 50 Oral Bone Loss and Systemic Osteopenia
Ch. 51 Localized Osteoporosis
Ch. 52 The Evaluation of Patients with Osteoporosis
Ch. 53 Radiology and Osteoporosis
Ch. 54 Use of Densitometry in Management of Osteoporosis
Ch. 55 Utility of Biochemical Markers of Bone Turnover in Osteoporosis
Ch. 56 Unexpected Consequences of Osteoporosis: An Evolving Basis for Treatment Decisions
Ch. 57 An Orthopedic Perspective of Osteoporosis
Ch. 58 Clinical Use of Bone Biopsy
Ch. 59 Design Considerations for Osteoporosis Trials
Ch. 60 ADFR - The Concept and Its Performance
Ch. 61 The Role of Calcium in the Treatment of Osteoporosis
Ch. 62 Vitamin D and Its Metabolites in the Management of Osteoporosis
Ch. 63 Estrogen: Prevention and Treatment of Osteoporosis
Ch. 64 Biphosphonates: Pharmacology and Use in the Treatment of Osteoporosis
Ch. 65 Calcitonin
Ch. 66 Fluoride Therapy for Osteoporosis
Ch. 67 Androgen and Androgenic Progestins
Ch. 68 Treatment with PTH Peptides
Ch. 69 Growth Hormone, Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
Ch. 70 Ipriflavone: In Vitro and in Vivo Effects on Bone Metabolism
Index
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