Osteoporosis

Overview

Now in its 4e, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic ...

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Osteoporosis: Two-Volume Set

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Overview

Now in its 4e, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.

  • Recognizes the critical importance of the Wnt signaling pathway for bone health
  • Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
  • Examines essential updates on estrogen prevention and treatment and the recent results from the WHO
  • Discusses the controversial topics of screening and clinical trial design for drug registration
  • Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
  • Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics

Audience: Researchers, academic clinicians, and libraries.

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Editorial Reviews

From the Publisher
Praise for Previous Editions:
"...interesting, comprehensive and up-to-date: each chapter has something new and important to say..."
-JOURNAL OF BONE AND JOINT SURGERY

"...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here..."
-THE NEW ENGLAND JOURNAL OF MEDICINE

Melissa Cavaghan
This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics. "The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management. "It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly. "The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available. "This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensiveand stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.
Booknews
Once a curiosity to a few endocrinologists or rheumatologists, osteoporosis has become (during the past two decades) a major focus of investigators and clinicians in fields as diverse as mechanical engineering, pediatrics, and epidemiology. In this hefty reference, 70 contributions cover all aspects of the subject, including the effects of numerous genetic and environmental factors, structural and biomechanical underpinnings, ethnoepidemiology, cellular mechanisms, radiologic assessment, clinical descriptions, and therapeutics. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Melissa K. Cavaghan, MD (Indiana University School of Medicine)
Description: This book comprehensively explores the topic of osteoporosis from basic biology underlying normal and disease states to clinical evaluation and therapeutics.
Purpose: The purpose is to provide the first thorough discussion of osteoporosis with enough depth and breadth to make it useful for both the basic investigator and the clinician. They successfully synthesize a foundation of biology, mechanics, epidemiology, and biochemistry to describe a complex condition and then expand upon this to describe varied disease states and clinical approaches to management.
Audience: It is aimed at both the researcher and the practitioner who deal with osteoporosis. It is probably must useful to the endocrinologist, but it is also of pertinent interest to orthopedists, rheumatologists, and general practitioners, especially of the elderly.
Features: The text is liberally illustrated, with a good balance of histologic reproductions (some in color) and diagrammatic illustration of biologic principles. It is fully and currently referenced. The authors' method of organization makes it extremely easy to find information very quickly. It is also extensively cross referenced, so all pertinent information is easily available.
Assessment: This is a comprehensive reference text of osteoporosis. If read cover to cover, the reader would be educated first on basic skeletal biology, including embryology, mechanics, and biochemistry, then on epidemiology and pathophysiology, and finally to the clinical disease states of osteoporosis, with emphasis on the varied other medical conditions that complicate or contribute to the development of osteoporosis. The basic and clinical sections are kept distinctly separate, but each discussion is comprehensive and stands alone. The authors give a thorough but concise historical review of the research leading up to current understanding in the field and provide direction for future research. It is so clearly written and organized that it can be used quickly and efficiently as a reference text but is also accessible to students and others with a minimal background in endocrinology.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780124158535
  • Publisher: Elsevier Science
  • Publication date: 7/12/2013
  • Edition number: 4
  • Pages: 2116
  • Sales rank: 1,101,028

Meet the Author

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

David W. Dempster, PhD, is Professor of Clinical Pathology and Cell Biology at Columbia University in New York. He obtained his PhD from the University of Glasgow in Scotland and completed postdoctoral studies in Switzerland and France. Dr. Dempster is a Past President of the International Society of Bone Morphometry and a member of the Scientific Advisory Council of the National Osteoporosis Foundation. He is also a Fellow of the Royal Microscopical Society. Dr. Dempster’s iconic micrographs of osteoporotic bone have been widely reproduced in the scientific and popular press, including being displayed at the Smithsonian Institution in Washington, DC. Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of the Journal of Bone and Mineral Research, Bone and the Journal of Clinical Densitometry. His research studies have been continuously supported by the National Institutes of Health for the past 25 years. Dr. Dempster has published over 200 research papers on the pathophysiology and treatment of bone disese.

Marjorie M. Luckey, MD is Medical Director of the Osteoporosis and Metabolic Bone Disease Center at the Saint Barnabas Medical Center in Livingston, NJ. She holds board certifications in Internal Medicine and Endocrinology and Metabolism and has been actively engaged in bone disease research, education, and patient care since 1982. As Associate Professor of Reproductive Science at Mount Sinai Medical Center in New York, New York, her independent research and publications included NIH-supported studies of bone health and calcium metabolism in African-American women; studies on the effects of organ transplantation, genetic diseases, and primary biliary cirrhosis on bone health; and investigations into laboratory testing in osteoporotic women. In addition, she has participated in many multinational trials of new therapeutic agents for osteoporosis.

Dr. Luckey is Chair of the Better Bones Project, a national education program designed to teach primary care physicians how to evaluate and treat osteoporosis. She is on the editorial board of the Journal of Clinical Densitometry, on the Scientific Advisory Council of the National Osteoporosis Foundation and is a member of the Bone Densitometry Certification Faculty for the International Society for Clinical Densitometry. She has also served on the Board of Directors of the International Society for Clinical Densitometry, the Practice Committee for The American Society of Bone and Mineral Research, and the National Bone Health Campaign Scientific Task Force for the Centers for Disease Control and Prevention.

Dr. Cauley is Professor and Vice Chair for Research, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (Pennsylvania). Her primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in menopause and the multiple physiological, social, pathological changes that occur during this time. Her research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. Her work has focused on use of hormone therapy, osteoporosis, risk of hip fractures and bone density in midlife women to older women.
She is the Principal Investigator (PI) of several large cohort studies including the Study of Osteoporotic Fracture (SOF) and the Osteoporotic Fracture Risk in Men Study (MrOS). Results from both of these studies have made major improvements in our understanding of osteoporosis in older men and women. Dr. Cauley was Co-PI for the Women's Health Initiative (WHI) and served as study wide Chair of the Osteoporosis, Calcium and Vitamin D Committee for almost the entire duration of the trial. She is a Co-investigator for the Study of Women's Health Across the Nation (SWAN) with particular emphases on skeletal health and physical function and body composition changes as women transition from midlife to elder status. She is also a PI of a SWAN ancillary study examining novel measures of hip strength. She has participated as a clinical center PI for major randomized clinical trials including the Fracture Intervention Trial, the Multiple Outcomes of Raloxifene Evaluation, the Heart Estrogen/Progestin Study, the HORIZON Pivotal Fracture Trial and the Testosterone Trial. She has published over 570 original research articles.

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Table of Contents

Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
Understanding of Osteoporosis
Basic Science/Bone Biology
Osteoblast Biology
Osteoclast Biology
Osteocytes
The Regulatory Role of Matrix Proteins in Mineralization of Bone
Development of the Skeleton
Mouse Genetics as a Tool to Study Bone Development and Physiology
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens and Skeletal Biology: Basic Mechanisms
Phosphatonins
Wnt Signaling in Bone
Cytokines and Bone Remodeling
Skeletal Growth Factors
Intercellular Communication During Bone Remodeling
Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth, Aging and Disease
Inhibition of Osteoporosis by Biophysical Intervention
Biomechanics of Age-Related Fractures
Bone Quality
Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis
Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Bone Acquisition in Adolescence
Genetic Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prev

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