Oxford Textbook of Clinical Pharmacology and Drug Therapy / Edition 3

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Overview


Completely updated, the new edition of the Oxford Textbook of Clinical Pharmacology and Drug Therapy continues to provide medical students and clinicians with a unique insight into why drugs have their therapeutic effects, by presenting the basic pharmacological principles of pharmacology as they effect the patient. An understanding of these clinical pharmacological principles is essential for rational, safe, effective, and economical prescribing. The text shows how knowledge of the scientific basis of drug action is applied in a clinical context to devise the most effective treatments for disease and to maximise the therapeutic effects of the drugs being used.
This new edition includes an appraisal of the value of evidence-based medicine and a greater discussion of issues in genetics. There are specialist contributors for areas of infectious disease, gastro-intestinal disorders, blood disorders, general anaesthesia, cancer chemotherapy and immunosuppression. The revision also includes updates to both the pharmacopoeia and the drug therapy section to reflect new developments in both available drugs and in their use. In particular, areas of cardiovascular disease and stomach ulcer have been substantially changed.
Aimed primarily at medical students, this book will also continue to be an invaluable source of information for trainees and clinicians.
The book is in four sections which provide:
-A detailed account of the principles of clinicians pharmacology, including adverse effects and drug interactions; pharmacogenetics; clinical trials; the discovery, development and marketing of drugs; drug treatment in the old and the young; and the use of drugs in relation to prenancy and other aspects of reproduction.
-Advice on practical matters of drug prescribing, both in a separate section and at appropriate points throughout the book.
-Detailed descriptions of the practical management of diseases with drugs, emphasizing the integration of principls with practice.
-A ready-reference pharmacopoeia of over 300 commonly used drugs, describing their uses, modes of action, pharmacokinetic properties, adverse effects, and interactions, with details of rational dosage regimens.
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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This third edition clinical pharmacology book is written by two experienced well-respected British clinical pharmacologists. The book is divided into four sections: section one deals with the scientific basis of drug therapy with a focus on evidence-based medicine; section two deals with the practical aspect of prescribing including sources of information on drugs; section three is on drug therapy of disease; and section four is a pharmacopoeia providing information on structure, mode of action, uses, dosages, kinetic data, important adverse effects, interactions and abbreviations of the most commonly used drugs in clinical practice in Great Britain.
Purpose: The purpose of this book is to bridge the scientific basis upon which the knowledge and understanding of drug therapy is built with the practical aspects of prescribing drugs in the treatment of disease. Thus, this book should be of valuable to the clinical pharmacology expert as well as the student in clinical training.
Audience: This book is written for the student in clinical training but should also be of great value to the resident and both general and specialist practitioners. Since the drugs used in Great Britain are some times different than those used in the U.S., the American reader will find discrepancies from U.S. accepted practice.
Features: The first section of the book deals with pharmaceutical, pharmacokinetic, pharmacodynamic, pharmacogenetic, and pharmacotherapeutic principles as well as with adverse reactions to drugs, drug-drug interactions and patient compliance. Special chapters are devoted to the use of drugs in the young, elderly, and during pregnancy. Drug discovery and development, regulations and clinical trials are discussed with respect to evidence-based medicine. The second section describes the practical aspect of prescribing drugs including benefit-to-risk ratio, evidence-based medicine, how to choose a drug, how to write a prescription, and sources of drug information. The third section describes drug therapy according to diseases. Appropriate drug therapy is presented based on relevant pathophysiology of the disease. This section has several valuable figures, schemes and tables. The fourth section is a pharmacopoeia of common drugs used in clinical practice in Great Britain.
Assessment: This is an excellent British clinical pharmacology book written by two experts in the field in consultation with several British pharmacology experts. The third edition, in addition to having updated information, has focused on changes that have been made in the standards by which the efficacy and safety of drug therapy are assessed. This book also addresses the current movement in medical education to emphasize "evidence-based medicine," Other additions include a discussion of surrogate markers of drug action in drug development and monitoring of drug therapy, developments in pharmacogenetics and pharmacogenomics and a discussion of hormonal replacement therapy.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780192632340
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/2002
  • Edition description: REV
  • Edition number: 3
  • Pages: 656
  • Product dimensions: 10.90 (w) x 8.60 (h) x 1.20 (d)

Meet the Author

both at University of Oxford
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Table of Contents

A note about drug nomenclature
Consulting authors
Sect. 1 Clinical pharmacology: the scientific basis of drug therapy
1 The four processes of drug therapy
2 The pharmaceutical process: is the drug getting into the patient?
3 The pharmacokinetic process: is the drug getting to its site of action?
4 The pharmacodynamic process: is the drug producing the required pharmacological effect?
5 The therapeutic process: is the pharmacological being translated into a therapeutic effect?
6 Practical applications of the analysis of drug therapy
7 Monitoring drug therapy
8 Pharmacogenetics and pharmacogenomics
9 Adverse reactions to drugs
10 Drug interactions
11 Drug therapy in young and old people
12 Drug therapy and reproduction
13 Patient compliance/concordance
14 Placebos
15 Drug discovery and development: the pharmaceutical industry and the regulatory authorities
16 Drug trials
17 The drug history and the clinical examination and investigation of drug effects
Sect. 2 Practical prescribing
18 Principles of prescribing
19 How to write a prescription
20 Sources of information on drugs
Sect. 3 The drug therapy of disease
21 Introduction to drug therapy
22 The drug therapy of infectious diseases
23 The drug therapy of cardiovascular disorders
24 The drug therapy of respiratory diseases
25 The drug therapy of gastrointestinal, hepatic, and biliary disorders
26 Drugs and the kidney and the drug therapy of renal, urinary tract, and prostatic disorders
27 The drug therapy of endocrine and metabolic disorders
28 The drug therapy of blood disorders
29 The drug therapy of disorders of bones and joints
30 The drug therapy of neurological disorders
31 The drug therapy of psychiatric disorders
32 The relief of pain
33 General anaesthesia and local anaesthetics
34 Drug dependence and abuse
35 The management of poisoning
36 The principles of cancer chemotherapy
37 Immunosuppression and the drug therapy of allergies, connective tissue disorders, and primary immunodeficiencies
Sect. 4 Pharmacopoeia
Introductory notes
Index to drugs listed in the pharmacopoeia
Pharmacopoeia
General index
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