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Doody's Review ServiceReviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This third edition clinical pharmacology book is written by two experienced well-respected British clinical pharmacologists. The book is divided into four sections: section one deals with the scientific basis of drug therapy with a focus on evidence-based medicine; section two deals with the practical aspect of prescribing including sources of information on drugs; section three is on drug therapy of disease; and section four is a pharmacopoeia providing information on structure, mode of action, uses, dosages, kinetic data, important adverse effects, interactions and abbreviations of the most commonly used drugs in clinical practice in Great Britain.
Purpose: The purpose of this book is to bridge the scientific basis upon which the knowledge and understanding of drug therapy is built with the practical aspects of prescribing drugs in the treatment of disease. Thus, this book should be of valuable to the clinical pharmacology expert as well as the student in clinical training.
Audience: This book is written for the student in clinical training but should also be of great value to the resident and both general and specialist practitioners. Since the drugs used in Great Britain are some times different than those used in the U.S., the American reader will find discrepancies from U.S. accepted practice.
Features: The first section of the book deals with pharmaceutical, pharmacokinetic, pharmacodynamic, pharmacogenetic, and pharmacotherapeutic principles as well as with adverse reactions to drugs, drug-drug interactions and patient compliance. Special chapters are devoted to the use of drugs in the young, elderly, and during pregnancy. Drug discovery and development, regulations and clinical trials are discussed with respect to evidence-based medicine. The second section describes the practical aspect of prescribing drugs including benefit-to-risk ratio, evidence-based medicine, how to choose a drug, how to write a prescription, and sources of drug information. The third section describes drug therapy according to diseases. Appropriate drug therapy is presented based on relevant pathophysiology of the disease. This section has several valuable figures, schemes and tables. The fourth section is a pharmacopoeia of common drugs used in clinical practice in Great Britain.
Assessment: This is an excellent British clinical pharmacology book written by two experts in the field in consultation with several British pharmacology experts. The third edition, in addition to having updated information, has focused on changes that have been made in the standards by which the efficacy and safety of drug therapy are assessed. This book also addresses the current movement in medical education to emphasize "evidence-based medicine," Other additions include a discussion of surrogate markers of drug action in drug development and monitoring of drug therapy, developments in pharmacogenetics and pharmacogenomics and a discussion of hormonal replacement therapy.