Oxidative Stress and Aging: Molecular and Cell Biology Updates

Oxidative Stress and Aging: Molecular and Cell Biology Updates

by Richard G. Cutler, A. Mori, J. Bertram

ISBN-10: 0817650393

ISBN-13: 9780817650391

Pub. Date: 01/28/1995

Publisher: Springer-Verlag New York, LLC

Product Details

Springer-Verlag New York, LLC
Publication date:
Molecular and Cell Biology Updates Series

Table of Contents

Oxidative stress, antioxidants, aging and disease1
Longevity determinant genes, cellular dysdifferentiation and oxidative stress15
Oxidative stress and apoptosis21
Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death27
Cellular aging and oxidative stress35
Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis45
Vascular smooth muscle cell proliferation is controlled by d [alpha]-tocopherol at the level of protein kinase C and of the transcription factor AP-153
DNA damage and epigenetic mechanisms of aging63
Formation of 8-hydroxyguanine in DNA by aging and oxidative stress69
Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress77
Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis89
DNA repair, oxidative stress and aging101
Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation111
Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila123
Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates141
Age-associated changes of oxidative modification and turnover of proteins151
Mitochondria, free radicals, neurodegeneration and aging159
Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone171
PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice179
Free radicals in the pathogenesis of diabetes and its complications191
Oxidative stress and its relationship to carcinogen activation203
The chemoprevention of cancer by dietary carotenoids: Studies in mouse and human cells221
Accumulation of ubiquitinated proteins in aging mouse brains237
Protective action of Bio-normalizer against oxidative stress and brain disorders245
Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress259
Free radical scavenger properties of EGB 761 on functional disorders induced by experimental diabetic retinopathy277
Oxidative stress in neurobiology: An important role for iron287
Parkinson's disease, dopamine and free radicals303
Oxidative stress and brain damage as the pathogenesis of epilepsy309
Senile neurodegeneration: Pathogenic role of microglia-derived free radicals319
Modulation of oxidative stress as a means of life-prolonging action of dietary restriction331
Dietary vitamin E in oxidative stress and aging343
Tea and its components as powerful antioxidants355
Protective role of dietary antioxidants in oxidative stress367
Nitrone spin-traps release nitric oxide reaction with reactive oxygen species: Possible mechanism of biological activity379
Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain

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