Oxidative Stress and Aging: Molecular and Cell Biology Updates

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Editorial Reviews

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Emerging from the First International Conference on Oxidative Stress and Aging, held in Hawaii in 1994, which brought together leading scientists in the fields of reactive oxygen species and molecular gerontology, 36 papers report on progress in the area. The topics include oxidative stress and cellular senescence; genetic stability, damage, and DNA repair; genetics and lifespan; proteins and lipid oxidation; mitochondria; aging-related diseases and cancer; aging- related diseases and neurodegeneration; nutrition; and nitric oxide. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

Preface
Oxidative stress, antioxidants, aging and disease 1
Longevity determinant genes, cellular dysdifferentiation and oxidative stress 15
Oxidative stress and apoptosis 21
Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death 27
Cellular aging and oxidative stress 35
Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis 45
Vascular smooth muscle cell proliferation is controlled by d [alpha]-tocopherol at the level of protein kinase C and of the transcription factor AP-1 53
DNA damage and epigenetic mechanisms of aging 63
Formation of 8-hydroxyguanine in DNA by aging and oxidative stress 69
Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress 77
Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis 89
DNA repair, oxidative stress and aging 101
Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation 111
Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila 123
Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates 141
Age-associated changes of oxidative modification and turnover of proteins 151
Mitochondria, free radicals, neurodegeneration and aging 159
Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone 171
PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice 179
Free radicals in the pathogenesis of diabetes and its complications 191
Oxidative stress and its relationship to carcinogen activation 203
The chemoprevention of cancer by dietary carotenoids: Studies in mouse and human cells 221
Accumulation of ubiquitinated proteins in aging mouse brains 237
Protective action of Bio-normalizer against oxidative stress and brain disorders 245
Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress 259
Free radical scavenger properties of EGB 761 on functional disorders induced by experimental diabetic retinopathy 277
Oxidative stress in neurobiology: An important role for iron 287
Parkinson's disease, dopamine and free radicals 303
Oxidative stress and brain damage as the pathogenesis of epilepsy 309
Senile neurodegeneration: Pathogenic role of microglia-derived free radicals 319
Modulation of oxidative stress as a means of life-prolonging action of dietary restriction 331
Dietary vitamin E in oxidative stress and aging 343
Tea and its components as powerful antioxidants 355
Protective role of dietary antioxidants in oxidative stress 367
Nitrone spin-traps release nitric oxide reaction with reactive oxygen species: Possible mechanism of biological activity 379
Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain
Index 393
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