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Doody's Review ServiceReviewer: Mark K Eskandari, M.D. R.V.T.(Northwestern University Feinberg School of Medicine)
Description: This is a thorough but concise review of the mechanisms of oxidative stress and how it has only recently been shown to play a critical role in a variety of vascular disease states.
Purpose: The purpose, as outlined by the editor, is to define oxidative stress and its mechanisms and then delve into the specific interactions of oxidative stress and a host of pathologic vascular disease states both in animal studies and humans. These goals have been successfully achieved.
Audience: The book is directed toward both basic scientists and clinicians with an interest in vascular biology. It is well written and at a level consistent with the anticipated audience. The editor has collected a competent group of scientists to assist in developing this book.
Features: The content is broken down into three main parts: the definition, mechanisms, and quanitification of oxidative stress and antioxidant defense systems; current hypotheses of the role of oxidative stress in vascular biology; and up-to-date animal and human studies to substantiate the current hypotheses. The references included in each section are extensive, current, and appropriate. Each chapter is accompanied by illustrations, tables, and/or graphs which are pleasing to the reader and allow for quick assessment of the data presented. The only shortcoming is the poor quality of the blot on page 187.
Assessment: This is a well-written and up-to-date reference on the pathophysiology of a variety of vascular disease states in which oxidative stress may play an intimate role.