Oxidative Stress and Vascular Disease / Edition 1

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Overview

The purpose of this book is to provide the reader with an overview of oxidative stress as it pertains to vascular diseases. The first part of the book is designed to help the reader grapple with important issues such as: Precisely what is oxidative stress? What markers are available to assess oxidative stress? and What are the precise sources of oxidative stress and antioxidant defenses in the vasculature? With this information as background, the book goes on to address the major vascular disease syndromes for which there is good evidence that oxidative stress may be involved. The greatest body of evidence exists for atherosclerosis and, accordingly, this is the most extensive section. However, we have taken great care to try and provide the reader with objective evidence for the role of oxidative stress in other diseases such as diabetes, hypertension, and vascular remodeling. In each instance, the book is designed to provide a solid overview of the basic science data required to evaluate the role of oxidative stress. Animal data is then presented and finally, where applicable, the role of oxidative stress in human disease is discussed with the appropriate reference to epidemiologic data. The book is designed to appeal to both scientists and clinicians with an interest in vascular disease and its underlying pathophysiology.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Mark K Eskandari, M.D. R.V.T.(Northwestern University Feinberg School of Medicine)
Description: This is a thorough but concise review of the mechanisms of oxidative stress and how it has only recently been shown to play a critical role in a variety of vascular disease states.
Purpose: The purpose, as outlined by the editor, is to define oxidative stress and its mechanisms and then delve into the specific interactions of oxidative stress and a host of pathologic vascular disease states both in animal studies and humans. These goals have been successfully achieved.
Audience: The book is directed toward both basic scientists and clinicians with an interest in vascular biology. It is well written and at a level consistent with the anticipated audience. The editor has collected a competent group of scientists to assist in developing this book.
Features: The content is broken down into three main parts: the definition, mechanisms, and quanitification of oxidative stress and antioxidant defense systems; current hypotheses of the role of oxidative stress in vascular biology; and up-to-date animal and human studies to substantiate the current hypotheses. The references included in each section are extensive, current, and appropriate. Each chapter is accompanied by illustrations, tables, and/or graphs which are pleasing to the reader and allow for quick assessment of the data presented. The only shortcoming is the poor quality of the blot on page 187.
Assessment: This is a well-written and up-to-date reference on the pathophysiology of a variety of vascular disease states in which oxidative stress may play an intimate role.
Mark K. Eskandari
This is a thorough but concise review of the mechanisms of oxidative stress and how it has only recently been shown to play a critical role in a variety of vascular disease states. The purpose, as outlined by the editor, is to define oxidative stress and its mechanisms and then delve into the specific interactions of oxidative stress and a host of pathologic vascular disease states both in animal studies and humans. These goals have been successfully achieved. The book is directed toward both basic scientists and clinicians with an interest in vascular biology. It is well written and at a level consistent with the anticipated audience. The editor has collected a competent group of scientists to assist in developing this book. The content is broken down into three main parts: the definition, mechanisms, and quanitification of oxidative stress and antioxidant defense systems; current hypotheses of the role of oxidative stress in vascular biology; and up-to-date animal and human studies to substantiate the current hypotheses. The references included in each section are extensive, current, and appropriate. Each chapter is accompanied by illustrations, tables, and/or graphs which are pleasing to the reader and allow for quick assessment of the data presented. The only shortcoming is the poor quality of the blot on page 187. This is a well-written and up-to-date reference on the pathophysiology of a variety of vascular disease states in which oxidative stress may play an intimate role.
Booknews
Keaney (medicine and pharmacology, Boston U.) presents 19 that deal with the hypothesis that oxidative modification of low density lipoprotein cholesterol and accompanying disturbances of oxidant/antioxidant balances may contribute to the initiation and progression of lesions in coronary arterial disease. After covering the basic concepts of oxidative stress, the articles cover it's relationship to aspects of atherosclerosis, diabetic vascular disease, and hypertension. The main goal of the work is to assess the possibilities of using new antioxidant compounds in the treatment of vascular disease. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780792386780
  • Publisher: Springer US
  • Publication date: 10/30/2007
  • Series: Developments in Cardiovascular Medicine Series , #224
  • Edition description: 2000
  • Edition number: 1
  • Pages: 373
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

List of Contributors. Foreword. Preface. General Concepts. 1. What is Oxidative Stress; H. Sies. 2. Sources of Vascular Oxidative Stress; J.W. Heinecke. 3. Antioxidant Defenses in the Vascular Wall; R. Sker. Atherosclerosis. 4. The Oxidative Modification Hypothesis of Atherogenesis; S. Tsimikas, J.L. Witztum. 5. Mechanisms of LDL Oxidation; M.R. McCall, B. Frei. 6. Oxidized Phospholipids as Mediators of Vascular Disease; S. Davies, et al. 7. MM-LDL and Atherogenesis - A Major Role for Phospholipid Oxidation Products; N. Leitinger, J.A. Berliner. 8. Oxidation-Sensitive Transcription and Gene Expression in Atherosclerosis; C. Kunsch, R.M. Medford. 9. Atherosclerosis, Oxidative Stress, and Endothelial Function; J.F. Keaney, Jr. 10. Oxidants and Antioxidants in Platelet Function; J.E. Freedman. 11. Antioxidants and Atherosclerosis: Animal Studies; J.F. keaney, Jr. 12. Human Studies of Antioxidants and Vascular Function; E.S. Biegelsen, J.A. Vita. 13. Antioxidants and Cardiovascular Disease; J.M. Gaziano. Diabetes. 14. Glycation and Glycoxidation in Diabetic Vascular Disease; S.R. Thorpe, et al. 15. Advanced Glycosylation Endproducts and Diabetic Vascular Disease; R. Bucala. 16. Hyperglycemia and Diabetes-Induced Vascular Dysfunction: Role of Oxidative Stress; G.M. Pieper. Hypertension and Vascular Remodeling. 17. The Role of Oxidative Stress in Hypertension; M.J. Somers, et al. 18. Protein Kinases That mediate Redox-Sensitive Signal Transduction; B.C. Berk. 19. Antioxidants and Restenosis: Animal Studies; J.F. Paolini, E.R. Edelman. Index.
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