Oxygen Transport to Tissue XXVI / Edition 1

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This book cover all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

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Product Details

Table of Contents

1 Cerebral oxygenation during repetitive apnea in newborn piglets 1
2 Optimal determination of detector placement in cerebral NIR spectroscopy of neonates using chemometric techniques 9
3 Simulation study of breast tissue hemodynamics during pressure perturbation 17
4 Microvascular oxygenation and oxidative stress during postischemic reperfusion : PO[subscript 2], ROS, and NO during reperfusion 23
5 Hypoxia, tumor endothelium, and targets for therapy 31
6 Genetic oxygen sensor : GFP as an indicator of intracellular oxygenation 39
7 Effects of insulin and catecholamines on inotropy and oxygen uptake : best perfusate for skeletal muscles 45
8 Adaptation to chronic hypoxia during diet-induced ketosis 51
9 Varied response of spontaneous tumors to antiangiogenic agents 59
10 Non-invasive measurement of tumor oxygenation using embedded microparticulate EPR spin probe 67
11 The effects of tumour blood flow and oxygenation modifiers on subcutaneous tumours as determined by NIRS 75
12 Hyperthermia and hypermetabolism in focal cerebral ischemia 83
13 Variability of cerebral hemoglobin concentration in very preterm infants during the first 6 hours of life
14 Computational study on use of single-point analysis method for quantitating local cerebral blood flow in mice 99
15 Effects of temperature on oxygen transport in sheets and spheres of respiring tissues 105
16 Modeling of the response of PtO2 in rat brain to changes in physiological parameters 111
17 Black magic and EPR oximetry : from lab to initial clinical trials
18 Axial oxygen diffusion in the krogh model : modifications to account for myocardial oxygen tension in isolated perfused rat hearts measured by EPR oximetry 127
19 Differentiating hemodynamic compromise by the OEF response to acetazolamide in occlusive vascular disease
20 The anomalous einstein-stokes behaviour of oxygen and other low molecular weight diffusants 143
21 Gut dysoxia : comparison of sites to detect regional gut dysoxia 151
22 Imaging oxygen pressure in the retina of the mouse eye 159
23 Fluorescence-mediated detection of a heterogeneity in a highly scattering media 167
24 Developing strategies for three-dimensional imaging of oxygen tension in the rodent retina 173
25 Cerebral PtO[subscript 2], acute hypoxia, and volatile anesthetics in the rat brain 179
26 Rate of change in cerebral oxygenation and blood pressure in response to passive changes in posture : a comparison between pure autonomic failure patients and controls
27 Validation of the CAS neonatal NIRS system by monitoring VV-Ecmo patients : preliminary results
28 Interactions between HIF-1 and Jab1 : balancing apoptosis and adaptation - outline of a working hypothesis 203
29 Past, present, and future of oxygen in cancer research 213
30 Benzoate hydroxylation : a measure of oxidative stress in divers 223
31 Mitochondrial NADH as the bellwether of tissue O[subscript 2] delivery 231
32 Process scale-up studies for protein C separation using IMAC 243
33 Hypoxia-induced alterations in hyaluronan and hyaluronidase
34 Rate of decrease of PO[subscript 2] from an arteriole with arrested flow 257
35 Measurement of CMRO[subscript 2] in neonates undergoing intensive care using near infrared spectroscopy 263
36 The pathways of oxygen in brain I : delivery and metabolism of oxygen 269
37 The pathways of oxygen in brain II : competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling 277
38 Exogenous and endogenous markers of tumour oxygenation status : definitive markers of tumour hypoxia? 285
39 The difficulties in comparing in vivo oxygen measurements : turning the problems into virtues 295
40 Preliminary study of simultaneous multi-anticoagulant deficiency diagnosis by fiber optic multi-analyte biosensor 303
41 Circulation time in man from lung to periphery as an indirect index of cardiac output
42 Factors controlling oxygen utilization 317
43 Amputation level viability in critical Limb Ischaemia : setting new standards 325
44 Hypoxia in breast cancer : role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion 333
45 Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging 343
46 Possible protective effects of [alpha]-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors 349
47 Simultaneous NIR-EPR spectroscopy of rat brain oxygenation 357
48 Microcirculation and reperfusion injury in organ transplantation 363
49 Focussing on genomic and phenomic correlations in respiration of non-melanotic skin cancers 375
50 Protein C production : metal ion/protein interfacial interaction in immobilized metal affinity chromatography 381
51 Modeling behavior of protein C during and after subcutaneous administration 389
52 Mechanisms for vasoconstriction and decreased blood flow following intravenous administration of cell-free native hemoglobin solutions 397
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