Oxygen Transport to Tissue XXXII / Edition 1

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Based on the 2009 proceedings of the 37th annual ISOTT conference, this volume covers all aspects of oxygen delivery to tissue, everything from near infrared spectroscopy, tumor biology, angiogenesis and mitochondrial metabolism to systems modeling, gas transport, hypoxic adaptation and exercise physiology. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biological bases for pathology related to tissue oxygenation. This multidisciplinary volume includes contributions from scientists, engineers, clinicians and mathematicians and is aimed and students and experts from a range of research fields.

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Product Details

Table of Contents

Part 1 – Near Infrared Spectroscopy Chapter 1
The Western Reserve, Edward Morley and Oxygen

Chapter 2
Analysis of the Changes in the Oxidation of Brain Tissue Cyhrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: A Broadband NIRS Study

Chapter 3
Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements using NIRS during a Valsalva Manoeuvre

Chapter 4
Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle. A Near-Infrared Spectrophotometry Study

Part 2 – Oxygen Sensors and Measurement Chapter 5
Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR Oximetry

Chapter 6
Challenges to Intestinal pO2 Measurement Using EPR

Chapter 7
Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

Chapter 8
Measuring Oxygen in Living Tissue: Intravascular, Interstitial and "Tissue" Oxygen Measurements

Chapter 9
Cerebral Oxygenation of the Cortex and Striatum following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators

Chapter 10
31P-MRS Studies of Melanoma Xenograft Metastatic Potential

Chapter 11
Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing Therapy

Part 3 – Blood and Blood Substitutes Chapter 12
MP4, A Vasodilatory PEGylated Hemoglobin

Chapter 13
Zymogen Protein C to Prevent Clotting Without Bleeding During Invasive Medical Procedures

Part 4 – Tumor Biology Chapter 14
Oxygenation Status of Urogenital Tumors

Chapter 15
Tumor pO2 as a Surrogate Marker to Identify Therapeutic Window during Metronomic Chemotherapy of 9L Gliomas

Chapter 16
Hypoxia-induced Extracellular Acidosis Increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway

Chapter 17
Evidence Against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells

Chapter 18
NMR Metabolic and Physiological Markers of Therapeutic Response

Chapter 19
Characterizing Breast Cancer Mouse Xenografts with T1p-MRI: A Preliminary Study

Chapter 20
Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer

Chapter 21
Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle

Part 5 – Presidential Symposium Chapter 22
Oral Pioglitazone Reduces Infarction Volume and Improves Neurologic Function Following MCAO in Rats

Part 6 – Angiogenesis Chapter 23
Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE)

Chapter 24
Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction

Part 7 – Mihondrial Metabolism Chapter 25
Regulation of Cytosolic and Mihondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13C NMR Spectroscopy

Chapter 26
In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance

Chapter 27
Elevated Mihondrial DNA Copy Number and POL-γ Expression but decreased Expression of TFAM in Murine Intestine following Therapeutic Dose Irradiation

Chapter 28
Heterogeneity of Mihondrial Redox State in Premalignant Pancreas in a PTEN Null Transgenic Mouse Model

Chapter 29
Potential Application of 17O MRI to Human Ischemic Stroke

Part 8 – Development Chapter 30
Fetal Cerebral Oxygenation: The Homeostatic Role of Vascular Adaptations to Hypoxic Stress

Chapter 31
Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and its Relation to Clinical Outcomes in Premature Infants

Part 9 – Systems Modeling Chapter 32
Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain

Chapter 33
Interpretation of NMR Spectroscopy Human Brain Data with Multi-Compartment Computational Model of Cerebral Metabolism

Chapter 34
Regional Brain Blood Flow in Mouse: Quantitative Measurement Using Single-Pass Radio-Tracer Method and Mathematical Algorithm

Part 10 – Microcirculation and Wound Healing Chapter 35
Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects

Chapter 36
Modeling O2-dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O2 Transport around Arterioles

Chapter 37
Skin SO2 Measurement Using Visible Lightguide Spectrophotometry in a Black Population: A Feasibility Study

Chapter 38
Antioxidant Properties of Quercetin

Chapter 39
Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin

Part 11 – Gas Transport Chapter 40
Impact of Intracellular Diffusion of Oxygen in Hypoxic Sensing

Chapter 41
The Micropores in the Vitteline Layer of the Eggs of the Dragonfly Oligoaeshna Pryeri: A Preliminary Observation from the View Point of Oxygen Uptake

Part 12 – Hypoxic Adaptation Chapter 42
A Heat-Shock Protein Co-Inducer Treatment Improves Behavioral Performance in Rats Exposed to Hypoxia

Chapter 43
Chronic Intermittent Hypoxia-induced Augmented Cardiorespiratory Outflow Mediated by Vasopressin-V1A Receptor Signaling in the Medulla

Chapter 44
The Effect of Inspiration of 12% O2 (balance N2) on Cardiac Output, Respiration, Oxygen Saturation and Oxygen Delivery

Chapter 45
Sufficient Oxygen Can Be Transported to Resting Skeletal Muscle

Part 13 – Exercise Physiology Chapter 46
Skeletal Muscle Perfusion and Oxygenation Assessed by Dynamic NMR Imaging and Spectroscopy

Chapter 47
Hemoglobin and Myoglobin Contributions to Skeletal Muscle Oxygenation in Response to Exercise

Chapter 48
Estimation of Muscle Fatigue Using Surface Electromyography and Near-Infrared Spectroscopy

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