P2 Purionoceptors: Localization, Function and Transduction Mechanisms -No. 198

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Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
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Chichester, West Sussex, England 1996 hardcover First Edition Very Good. No Dust Jacket Clean Copy Symposium held at Ciba Foundation, London, 11-13 July 1995. Almost new ... condition. Illustrated by 72 text-figures and 14 tables. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
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Editorial Reviews

Booknews
Proceedings of the July 1995 symposium. 18 papers along with discussions of each, cover specific receptors for extracellular ATP that recognize the triphosphate nucleotide, but not adenosine. Topics include receptor pharmacology; transduction mechanisms; the cloning and expression of genes for P2 purinoceptor subtypes; and the distribution and biological roles of P2 purinoceptors. The possibilities afforded by P2 purinoceptor ligands as potential therapeutic entities are also discussed. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471961253
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 8/1/1996
  • Series: Novartis Foundation Symposia Series , #126
  • Edition number: 1
  • Pages: 346
  • Product dimensions: 6.20 (w) x 9.27 (h) x 0.85 (d)

Table of Contents

P2 purinoceptors: historical perspective and classification 1
The diadenosine polyphosphate receptors: P2D purinoceptors 35
P2T purinoceptors: ADP receptors on platelets 53
P2Z purinoceptors 71
P2X receptors: a third major class of ligand-gated ion channels 91
P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes 110
Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal transduction mechanisms 130
Trophic roles of P2 purinoceptors in central nervous system astroglial cells 142
Transduction mechanisms of P2Z purinoceptors 149
The diverse series of recombinant P2Y purinoceptors 166
General discussion I: Molecular modelling of P2Y purinoceptors 189
P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis 193
Functional properties of native and cloned P2X receptors 208
ATP as a co-transmitter with noradrenaline in sympathetic nerves - function and fate 223
ATP release and its prejunctional modulation 239
General discussion II: Distribution of purinoceptors 260
General discussion II: ATP as a neurotransmitter 261
Involvement of distinct receptors in the actions of extracellular uridine nucleotides 266
Features of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell? 278
P2 purinoceptors in the immune system 290
General discussion III: Purinoceptors and the pancreas 306
Challenges in developing P2 purinoceptor-based therapeutics 309
Summing-up 322
Index of contributors 324
Subject index 326
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