Paraneoplastic Syndromes

Paraneoplastic Syndromes

by Robert B. Darnell, Jerome B. Posner
     
 

Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This

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Overview

Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The section discusses the clinical findings and treatment of individual paraneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplastic syndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.

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Editorial Reviews

From the Publisher
"In a field such as paraneoplastic syndromes that is changing constantly, Drs Posner and Darnell have written a book to stay. Divided in 17 chapters covering historical aspects, individual syndromes, type of immune responses, and specific cancers the authors describe in a detail only possible from physicians with extensive experience, all paraneoplastic neurological and non-neurological syndromes known to date. There are abundant and excellent vignettes, tables, and pictures. Given that any part of the nervous system and any organ may be affected by these disorders, this is a book that any physician should read and keep on the bookshelf." —Josep Dalmau, MD, PhD, ICREA Research Professor, IDIBAPS/Hospital Clinic, University of Barcelona, Spain, and adjunct Professor of Neurology, University of Pennsylvania, Philadelphia, PA

"Paraneoplastic Syndromes is another wonderful volume in the distinguished Contemporary Neurology Series by Robert Darnell and Jerry Posner...This book may be read as a single unit, or it may be used as a complete resource for selective referencing. The illustrations and figures are of high quality and descriptive. This book will be useful for students, residents, and the experienced practitioner who is looking for a definitive book on this topic. It is written to help the clinician with understanding the pathophysiology and diagnosis of this baffling disease syndrome. Moreover, basic scientists and neuroanatomists will appreciate the care that has been placed into the analysis of the anatomical pathophysiology of this disease." — Thomas Chen, MD, PhD, Director, USC Neuro-oncology, Departments of Neurosurgery and Pathology, Los Angeles, CA

"Dr. Posner and Dr. Darnell's Paraneoplastic Syndromes is a comprehensive and accessible review by two of the world's experts of an area of medicine that bridges the fields of neurology, oncology, and immunology. Despite the potential complexity of these disorders, the thoughtful organization and clarity of presentation of this volume, with sections organized by specific clinical syndromes, antibodies, and cancer types, makes this an essential reference both clinicians and scientists with an interest in paraneoplastic syndromes." —Howard Colman, MD, PhD, Director of Medical Neuro-Oncology, Department of Neurosurgery and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT

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Product Details

ISBN-13:
9780199772735
Publisher:
Oxford University Press, USA
Publication date:
08/22/2011
Series:
Contemporary Neurology Series, #79
Pages:
496
Product dimensions:
7.40(w) x 10.10(h) x 1.20(d)

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