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Overview

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital ...
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The Parathyroids: Basic and Clinical Concepts

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Overview

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians.

Key Features
* Offers objective and authoritative reviews on controversial clinical issues
* Written by world experts on parathyroid hormone and its disorders
* Superb, state-of-the-art compendium in one convenient volume
* Bridges basic science of parathyroid hormone to major clinical disorders
* Practical information on clinical management of parathyroid hormone disorders

Audience: Students, researchers, fellows, and professionals in endocrinology and bone/mineral research.

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Editorial Reviews

Maria M. Byrne
This book contains a comprehensive examination of the physiology and biochemistry of parathyroid hormone and a discussion of diseases of the parathyroid. The purpose is to summarize all of the recent advances in the area of the parathyroid glands. It discusses the basic and clinical concepts of the parathyroid in detail. This is an important and timely review of this area. This book is written for students, teachers, practitioners, and individuals working in the area of calcium research. It is a useful book for endocrinologists in particular. The authors and contributors are very solid and credible in their respective areas. This book has numerous illustrations, graphs, charts, and tables appropriate for this text. It contains extensive up-to-date references. The unique feature of this book is its excellent division into basic concepts followed by clinical concepts. This is an excellent textbook reviewing basic concepts and clinical concepts regarding the parathyroids. It is a most useful textbook for students, teachers, practitioners, or individuals working in the area of calcium metabolism. The library, bookstore, and individuals could purchase this text. It is a tremendous summary of all that is currently known about the parathyroids.
Bart L. Clarke
It represents a significant contribution to the field,and likely will continue to do so for many editions.
From The Critics
...a comprehensive source of information that most endocrinologists will want to have on their bookshelves.
Booknews
A text that provides a comprehensive examination of basic and clinical concepts of the parathyroids, for students, teachers, practitioners, and investigators of the field. Section I, Basic Concepts of the Parathyroids, includes subsections on anatomy and physiology (7 chapters); parathyroid hormone--structure, function, receptors, mechanisms of action (9 chapters); and causes and management of hypercalcemia due to parathyroid hormone-related protein and other factors (6 chapters). Section II, Clinical Concepts of the Parathyroids, includes subsections on the hyperparathyroid states (18 chapters); the parathyroids in the reactive hyperparathyroidism of renal disease (2 chapters); the hyperparathyroid states (5 chapters); and the parathyroids in other disorders of mineral metabolism (4 chapters). Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Maria M. Byrne, MD (University of Chicago Medical Center)
Description: This book contains a comprehensive examination of the physiology and biochemistry of parathyroid hormone and a discussion of diseases of the parathyroid.
Purpose: The purpose is to summarize all of the recent advances in the area of the parathyroid glands. It discusses the basic and clinical concepts of the parathyroid in detail. This is an important and timely review of this area.
Audience: This book is written for students, teachers, practitioners, and individuals working in the area of calcium research. It is a useful book for endocrinologists in particular. The authors and contributors are very solid and credible in their respective areas.
Features: This book has numerous illustrations, graphs, charts, and tables appropriate for this text. It contains extensive up-to-date references. The unique feature of this book is its excellent division into basic concepts followed by clinical concepts.
Assessment: This is an excellent textbook reviewing basic concepts and clinical concepts regarding the parathyroids. It is a most useful textbook for students, teachers, practitioners, or individuals working in the area of calcium metabolism. The library, bookstore, and individuals could purchase this text. It is a tremendous summary of all that is currently known about the parathyroids.
From the Publisher
"...a comprehensive source of information that most endocrinologists will want to have on their bookshelves."
-TRENDS IN ENDOCRINOLOGY AND METABOLISM (April 2003)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780080525778
  • Publisher: Elsevier Science
  • Publication date: 7/21/2001
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 2
  • Pages: 881
  • File size: 26 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.
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Table of Contents

Basic Elements of the Parathyroid System
Embryology, Anatomy, and Pathology
Parathyroid Hormone: Gene Structure, Biosynthesis, Metabolism
Parathyroid Hormone-related Protein: Gene Structure, Biosynthesis, Metabolism
Structure-function Analysis of PTH and PTHRP
Receptors for Parathyroid Hormone and PTHRP: Signaling and Regulation
Nuclear targeting: Signaling for PTHRP
Signal Transduction of PTH and PTHRP
Receptors and Signaling for Calcium Ion
Immunoassays for PTH and PTHRP: Clinical Applications
Physiological Aspects of the Parathyroids
Physiology of Calcium Homeostasis
Anabolic and Catabolic Effects of Parathyroid Hormone on Bone: Interaction with Growth Factors
Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation
Physiological Actions of PTH and PTHRP I: Skeletal Actions
Physiological Actions of PTH and PTHRP II: Renal Actions
Physiological Actions of PTH and PTHRP III: Chondrocyte, Tooth, and Bone Development
Physiological Actions of PTH and PTHRP IV: Vascular and Cardiovascular, Neurological Actions
Physiological Actions of PTH and PTHRP V: Mammary, Reproductive, Epidermal, and Pancreatic Tissue - PTH and PTHRP as Polyhormones
Clinical Aspects Primary Hyperparathyroidism
Normal and Abnormal Growth of Parathyroid Cells
Molecular Genetics of Primary Hyperparathyroidism
Clinical Presentation of Primary Hyperparathyroidism: US
Clinical Presentation of Primary Hyperparathyroidism: Europe
Clinical Presentation of Primary Hyperparathyroidism: India, Brazil, China
Clinical Course of Primary Hyperparathyroidism
Bone Turnover in Primary Hyperparathyroidism
Cytokines in Primary Hyperparathyroidism
Histomorphometric Analysis of Bone in Primary Hyperparathyroidism
Nephrolithiasis in Primary Hyperparathyroidism
Guidelines for the Medical or Surgical Management of Primary Hyperparathyroidism
Medical Management of Primary Hyperparathyroidism
Preoperative Localization of Parathyroid Tissue in Primary Hyperparathyroidism
Surgical Management of Primary Hyperparathyroidism
Ectopic Locations of Parathyroid Glands
Parathyroid Carcinoma
Acute Primary Hyperparathyroidism
Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasia Type II
Familial Forms of Primary Hyperparathyroidism
Familial Hypocalciuric Hypercalce
Secondary Hyperparathyroidism
Parathyroids in Renal Disease: Pathophysiology
Hyperparathyroidism in Renal Failure: Clinical Features, Diagnosis, and Management
Special Considerations
Evaluation of the Hypercalcemic Patient: Differential Diagnosis
Hypercalce Due to PTHRP
Other Local and Ectopic Secretion Syndromes Associated with Hypercalce
Jansen's Disease
Acute Management of Hypercalce
Primary Hyperparathyroidism and Other Causes of Hypercalce in Children and Adolescents
The Hypoparathyroid States
Hypoparathyroidism in Differential Diagnosis of Hypocalce
Parathyroid Function in Magnesium Deficiency
Molecular Genetics of Hypoparathyroidism
Autoimmune Aspects of Hypoparathyroidism
Pseudohypoparathyroidism: Clinical, Biochemical, and Molecular features
Treatment of Hypoparathyroidism
The Parathyroids in Osteoporosis
Parathyroid Function in the Normal Aging Process
Parathyroid Function and Responsiveness in Osteoporosis
Parathyroid Hormone and Growth Hormone in the Treatment of Osteoporosis
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