Parkinson's Disease

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Since the publication of the first edition of this book in 1982, there have been radical changes in our understanding of Parkinson's disease, its treatment, and in social attitudes towards the condition. This new edition discusses these changes, presenting revised and updated information in answer to questions commonly asked by both patients and their families. It covers the history of the illness, the evolution of medical knowledge, the signs and symptoms of the disease, and how it is treated, including such ...
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Overview

Since the publication of the first edition of this book in 1982, there have been radical changes in our understanding of Parkinson's disease, its treatment, and in social attitudes towards the condition. This new edition discusses these changes, presenting revised and updated information in answer to questions commonly asked by both patients and their families. It covers the history of the illness, the evolution of medical knowledge, the signs and symptoms of the disease, and how it is treated, including such radical new therapies as brain implants. The book also offers practical advice on living with Parkinsonism. It is the only such book to be written at a level easily accessible to nonspecialists.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Booknews
Tightly organized and well-honed presentation. Revised edition (first published in 1982) considers: nematodes, cestodes, trematodes, protozoa, arthropods. Highlighted by a series of 350 illustrations, including 34 parasitic life cycle drawings. Twenty-three contributions from North America and Europe and from a variety of perspectives consider experimental and clinical advances in the understanding and treatment of Parkinson's disease. The papers are arranged in three sections, addressing neurosciences, clinical considerations, and therapy of Parkinson's disease. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780781715980
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 6/28/1999
  • Series: Advances in Neurology Series
  • Edition number: 1
  • Pages: 670

Table of Contents

Contributing Authors
Preface
Foreword: Welcoming Addresses
Acknowledgments
1 Glia: A Curtain Raiser 3
2 Glial Cell Participation in the Degeneration of Dopaminergic Neurons in Parkinson's Disease 9
3 Neurotrophins in the Pathogenesis and Potential Treatment of Parkinson's Disease 19
4 Pathophysiology of the Motor Cortex in Patients with Parkinson's Disease 27
5 The Role of Cortico-Striatal Circuits in Learning Sequential Information 31
6 Motor Skills in Motor Disorders: Measuring Performance Changes in Tracking and Other Perceptual-Motor Tasks 41
7 The Cognitive Neuropsychology of Parkinson's Disease: A Functional Neuroimaging Perspective 49
8 Neurophysiological Tests for the Assessment of Tremors 57
9 Functional Consequences of Dopaminergic Degeneration in Parkinson's Disease 67
10 Advances in Understanding the Neural Mechanisms Underlying L-DOPA-Induced Dyskinesia 71
11 The Metabolic Landscape of Parkinson's Disease 87
12 Nonisotopic Surrogates for Technetium as Ligands for Monoamine Transporters 99
13 Localization of Adenosine A[subscript 2A] Receptors in Brain: Therapeutic Implications 105
14 Adenosine Receptor Antagonists and Parkinson's Disease: Actions of the A[subscript 2A] Receptor in the Striatum 111
15 Antiparkinsonian Activity of Adenosine A[subscript 2A] Antagonists in Experimental Models 121
16 Metabolism of Adenosine Increase in the Striatum in Common Marmoset Parkinsonism Induced by MPTP 125
17 Glutamate Receptor-Mediated Mechanisms in Levodopa-induced Motor Fluctuations in an Experimental Model of Parkinsonism 129
18 Neurotrophins and Cytokines in Parkinson's Disease 135
19 Is Parkinson's Disease an Inherited Condition? 143
20 Epidemiology of Parkinson's Disease 153
21 Genetic and Environmental Factors in Parkinson's Disease 161
22 The Contursi Kindred, a Large Family with Autosomal Dominant Parkinson's Disease: Implications of Clinical and Molecular Studies 165
23 Genetic and Environmental Factors in the Pathogenesis of Parkinson's Disease 171
24 Clinical Genetic Study of Familial Parkinson's Disease in Italy 181
25 Dopamine Cell Death by a Single Genetic Mechanism: Phenotypic Analysis and Linkage Study of Autosomal Recessive Juvenile Parkinsonism 187
26 Molecular Genetics of DOPA-Responsive Dystonia 195
27 Toxins, Genetics, and Parkinson's Disease: The Role of N-Acetyltransferase 2 199
28 Mechanisms of Neuronal Death in Idiopathic Parkinsonism 205
29 Idiopathic Parkinson's Disease: A Genetic and Environmental Model 215
30 Time Sequences of Dopaminergic Cell Death in Parkinson's Disease: Indications for Neuroprotective Studies 219
31 Etiology of Parkinson's Disease: Contributions from [superscript 18]F-DOPA Positron Emission Tomography 227
32 Mitochondrial DNA in Parkinson's Disease 233
33 Nitric Oxide in the Pathogenesis of Parkinson's Disease 239
34 Nitric Oxide and Basal Ganglia Degeneration 247
35 N-methyl(R)salsolinol, a Dopamine Neurotoxin, in Parkinson's Disease 259
36 Oxidative Stress and Neuroprotection in Parkinson's Disease: Implications from Studies on Dopamine-Induced Apoptosis 265
37 P450 and Heme Oxygenase Enzymes in the Basal Ganglia and Their Roles in Parkinson's Disease 271
38 Role of Iron in 6-Hydroxydopamine Neurotoxicity 287
39 Apomorphine, a Dopamine Receptor Agonist with Remarkable Antioxidant and Cytoprotective Properties 297
40 Movement Disorders with Tau Protein Cytoskeletal Pathology 303
41 Pathobiology of the Lewy Body 313
42 Preclinical Diagnosis of Parkinson's Disease 327
43 Parkinsonian and Essential Tremors: Different Entities or Different Manifestations of the Same Disorder? 335
44 Progressive Supranuclear Palsy 341
45 Urinary and Anorectal Function Evaluation in Parkinson's Disease 347
46 Separating the Primary Autonomic Failure Syndromes, Multiple System Atrophy, and Pure Autonomic Failure from Parkinson's Disease 353
47 Apomorphine Test in the Assessment of Parkinsonian Patients: A Meta-Analysis 363
48 Rare and Unusual Parkinsonian Syndromes 369
49 Saccades and Antisaccades in Parkinsonian Syndromes 377
50 Visual and Visual Cognitive Dysfunction in Parkinson's Disease: Spatial and Chromatic Vision 383
51 DOPA-Responsive Dystonic Parkinsonism - Pathophysiologic Considerations 389
52 Psychosis and Hallucinations in Parkinson's Disease 401
53 The Place of Dementia in Parkinson's Disease: A Methodologic Saga 403
54 Clinicopathological Heterogeneity and Non-Dopaminergic Influences on Behavior in Parkinson's Disease 409
55 Hallucinations in Parkinson's Disease: The Clinical Syndrome 419
56 Dopamine, Serotonin, and Schizophrenia 425
57 Evaluating Community-based Parkinson's Disease Nurse Specialists: Rationale, Methodology, and Representativeness of Patient Sample in a Large Randomized Controlled Trial 431
58 Standardized Quantitative Measurements in Parkinson's Disease 439
59 Theoretical Basis and Problems of Quantification of Movement Disorders 443
60 Objective Assessment in Parkinson's Disease: Optoelectronic Movement and Force Analysis in Clinical Routine and Research 447
61 Adolf Hitler's Cognitive Disorder and How It Affected His Conduct of World War II 459
62 Notable Europeans with Parkinson's Disease 467
63 Art and Parkinson's Disease 471
64 Do We Need More Drugs to Treat Parkinson's Disease? 481
65 Clinical Pharmacology of Levodopa-Induced Dyskinesia in Parkinsonian Patients 485
66 COMT Inhibition with Entacapone in the Treatment of Parkinson's Disease 491
67 Pharmacology of Rasagiline (N-propargyl-1R-aminoindan) 495
68 Evidence Suggesting the Role of Norepinephrine Deficiency in Late Stages of Parkinson's Disease 501
69 Combined and Selective Monoamine Oxidase Inhibition in the Treatment of Depression in Parkinson's Disease 505
70 Moclobemide in Patients with Dementia and Depression 509
71 Lazabemide for the Treatment of Alzheimer's Disease: Rationale and Therapeutic Perspectives 521
72 Use of Apomorphine in Clinical Practice 529
73 Future Delivery Systems for Apomorphine in Patients with Parkinson's Disease 535
74 Effects of Long-term, Continuous Subcutaneous Apomorphine Infusions on Motor Complications in Advanced Parkinson's Disease 545
75 New Delivery Systems for Antiparkinsonian Drugs 549
76 Interdisciplinary Rehabilitation in Parkinson's Disease 555
77 Pragmatic Physical Therapy in Parkinson's Disease: Any Scientific Basis? 561
78 Traditional and Complementary Therapies in Parkinson's Disease 565
79 Posteroventral Medial Pallidotomy in Advanced Parkinson's Disease 575
80 Image-Guided Eletrophysiologically Controlled Posteroventral Pallidotomy for the Treatment of Parkinson's Disease: A 28-Case Analysis 585
81 Current Controversies in Pallidal Surgery 593
82 Surgical Treatment of Levodopa-Induced Dyskinesias 603
83 New Aspects in the Pathophysiology of Dyskinesia 611
84 Reversal of Levodopa Failure Syndrome by Posteroventral-ansa Pallidotomy 619
85 Long-term Electrostimulation of the Ventroposterolateral Pallidum in the Treatment of Parkinson's Disease 623
86 Effect of Long-term Stimulation of the Ventral Intermediate Thalamic Nucleus on Gait in Parkinson's Disease 627
87 Long-term Ventralis Intermedius Thalamic Stimulation for Parkinsonian Tremor 631
88 Neural Transplantation: Can We Improve the Symptomatic Relief? 635
89 The Case for Neural Tissue Transplantation as a Treatment for Parkinson's Disease 641
90 The Need for Phase III Studies in Experimental Surgical Treatments of Parkinson's Disease 651
Subject Index 655
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