Pathogenesis and Treatment of Diabetes Mellitus

by J.K. Radder, H.H.P.J. Lemkes, H.M.J. Krans

Overview

In this book on diabetes mellitus both the pathogenesis and treatment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol­ ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre­ disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto­ immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out­ break of the disease, the destructive process has already been active for years.

Product Details

ISBN-13:	9789401084116
Publisher:	Springer Netherlands
Publication date:	09/27/2011
Edition description:	Softcover reprint of the original 1st ed. 1986
Pages:	188
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

1.: Pathogenesis of Diabetes Mellitus.- Section 1.1.: Type I Diabetes Mellitus.- 1.1.1.: Introduction: Type I Diabetes Mellitus.- 1.1.2.: Autoimmune pathogenesis of viral diabetes.- 1.1.3.:Immunological features of insulin-dependent diabetes mellitus.- 1.1.4.:Genetic counselling in Diabetes Mellitus.- Section 1.2.: Type II Diabetes Mellitus.- 1.2.1.: Introduction: Pathogenesis of type II Diabetes Mellitus.- 1.2.2.:Insulin secretion in noninsulin-dependent Diabetes Mellitus.- 1.2.3.: Insulin antagonism.- 1.2.4.: The contribution of the central nervous system to the regulation of insulin release and the stabilization of blood glucose.- 1.2.5.: Cellular insulin resistance.- 2.: Treatment of Diabetes Mellitus.- Section 2.1.: Diet and hypoglycaemic agents.- 2.1.1.: Introduction: Diet and hypoglycaemic agents.- 2.1.2.: Diet and Diabetes.- 2.1.3.: Oral hypoglycaemic drugs.- Section 2.2.: Insulin.- 2.2.1.: Introduction: Insulin treatment.- 2.2.2.: Hyperinsulinaemia.- 2.2.3.: Insulin: The physiological basis of its administration.- 2.2.4.: Diabetes Technology: From the pump to the microprocessor.- Section 2.3.: Pancreas transplantation.- 2.3.1.: Introduction: Pancreas transplantation.- 2.3.2.: Current state of pancreas transplantation.- Index of subjects.