Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model

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Examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the rabbit model.
• Reviews the interplay of delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses.
• Covers the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development.
• Focuses on areas of future research that could contribute to the knowledge, treatment, and control of this disease.
• Serves as a resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology.
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Product Details

  • ISBN-13: 9781555813734
  • Publisher: ASM Press
  • Publication date: 9/28/2006
  • Pages: 486
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.00 (d)

Table of Contents

Table of Contents


Section 1. Pathogenesis of Tuberculosis

1. Overview
2. Stages in the Pathogenesis of Human and Rabbit Tuberculosis
3. Types of Human Pulmonary Tuberculosis
4. Liquefaction of Caseous Foci and Cavity Formation
Section 2. Immunology of Tuberculosis

5. Delayed-Type Hypersensitivity, Cell-Mediated Immunity, and Antibodies in Tuberculosis
6. Macrophages and Other Cells in Tuberculosis Lesions
Section 3. Tuberculous Lesions

7. Structural Components of Tuberculous Lesions
8. Microvascular Density in Tuberculosis Lesions
9. Early Pulmonary Lesions in Rabbits
10. Macrophage Turnover, Division, and Activation in Tuberculosis Lesions
11. Lurie's Pulmonary Tubercle-Count Method
Section 4. Tuberculosis in Rabbits and Other Common Laboratory Animals

12. Natural Airborne Infection
13. Response of Rabbits to Inhaled Tubercle Bacilli Including BCG
14. Characteristics of Resistance and Susceptibility to Tuberculosis in Lurie's Inbred Rabbit
15. Comparisons of Tuberculosis in Rabbits, Mice, and Guinea Pigs
Section 5. Effects of Hormones and X-Irradiation on Tuberculosis

16. Effects of Cortisone and Adrenocorticotropic Hormone on Tuberculosis
17. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis
18. Effects of Whole-Body X-Irradiation on Tuberculosis
Section 6. Cytokines and Vascular Adhesion Molecules in Tuberculous Lesions

19. Cytokine Production in Primary BCG Lesions
20. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions
21. Vascular Adhesion Molecules in Tuberculous Lesion
Section 7. Tuberculosis Vaccines

22. Principles and Guidelines for Developing Better Tuberculosis Vaccines
23. Characteristics of Rabbit BCG Lesions and Efficacies of BCG and Mycobacterium microti Vaccines
Section 8. Past, Present, and Future

24. Summary and Conclusions
25. Suggested Future Research and Unanswered Questions

A. Award of the Trudeau Medal of the National Tuberculosis Association to Max B. Lurie
B. Obituary of Max B. Lurie
C. Publications of Max B. Lurie
D. Publications of Arthur M. Dannenberg, Jr.
E. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 (Centers for Disease Control and Prevention; Table of Contents)
F. Collected Abstracts of Chapters in This Volume
G. Acknowledgments

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