Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model

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This book provides in-depth insights into the pathogenesis of human tuberculosis and can serve as both a guide for future research and for the treatment of the disease. It covers the seminal work of Max B. Lurie in the rabbit model of tuberculosis, and the work of the author, who continued to research using the rabbit model after Lurie's death in 1966. updates Lurie's last work that was published in 1964 covering tuberculosis in the rabbit model offers an authoritative account of the current research using the rabbit model presents the pathogenesis of tuberculosis from the inhalation of the bacillus to a fully developed disease and its various manifestations details the key principles of tuberculosis pathogenesis illustrations the pathology of human disease using images from the renowned collection of A. R. Rich and W. G. MacCallum of the Johns Hopkins School of Medicine provides a comparison of tuberculosis in rabbits, mice, guinea pigs, and monkeys.

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Product Details

  • ISBN-13: 9781555813734
  • Publisher: ASM Press
  • Publication date: 9/28/2006
  • Pages: 486
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.00 (d)

Table of Contents

Table of Contents


Section 1. Pathogenesis of Tuberculosis

1. Overview
2. Stages in the Pathogenesis of Human and Rabbit Tuberculosis
3. Types of Human Pulmonary Tuberculosis
4. Liquefaction of Caseous Foci and Cavity Formation
Section 2. Immunology of Tuberculosis

5. Delayed-Type Hypersensitivity, Cell-Mediated Immunity, and Antibodies in Tuberculosis
6. Macrophages and Other Cells in Tuberculosis Lesions
Section 3. Tuberculous Lesions

7. Structural Components of Tuberculous Lesions
8. Microvascular Density in Tuberculosis Lesions
9. Early Pulmonary Lesions in Rabbits
10. Macrophage Turnover, Division, and Activation in Tuberculosis Lesions
11. Lurie's Pulmonary Tubercle-Count Method
Section 4. Tuberculosis in Rabbits and Other Common Laboratory Animals

12. Natural Airborne Infection
13. Response of Rabbits to Inhaled Tubercle Bacilli Including BCG
14. Characteristics of Resistance and Susceptibility to Tuberculosis in Lurie's Inbred Rabbit
15. Comparisons of Tuberculosis in Rabbits, Mice, and Guinea Pigs
Section 5. Effects of Hormones and X-Irradiation on Tuberculosis

16. Effects of Cortisone and Adrenocorticotropic Hormone on Tuberculosis
17. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis
18. Effects of Whole-Body X-Irradiation on Tuberculosis
Section 6. Cytokines and Vascular Adhesion Molecules in Tuberculous Lesions

19. Cytokine Production in Primary BCG Lesions
20. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions
21. Vascular Adhesion Molecules in Tuberculous Lesion
Section 7. Tuberculosis Vaccines

22. Principles and Guidelines for Developing Better Tuberculosis Vaccines
23. Characteristics of Rabbit BCG Lesions and Efficacies of BCG and Mycobacterium microti Vaccines
Section 8. Past, Present, and Future

24. Summary and Conclusions
25. Suggested Future Research and Unanswered Questions

A. Award of the Trudeau Medal of the National Tuberculosis Association to Max B. Lurie
B. Obituary of Max B. Lurie
C. Publications of Max B. Lurie
D. Publications of Arthur M. Dannenberg, Jr.
E. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 (Centers for Disease Control and Prevention; Table of Contents)
F. Collected Abstracts of Chapters in This Volume
G. Acknowledgments

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