Pathophysiology: The Biologic Basis for Disease in Adults and Children / Edition 6

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With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What’s New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available!

  • Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text.
  • A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms.
  • Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition.
  • Chapter summary reviews provide concise synopses of the main points of each chapter.
  • Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment.
  • Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content.
  • Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes.
  • Nutrition and Disease boxes explain the link between concepts of health promotion and disease.
  • EXTENSIVELY Updated content reflects advances in pathophysiology including tumor biology invasion and metastases, the epidemiology of cancer, diabetes mellitus, insulin resistance, thyroid and adrenal gland disorders, female reproductive disorders including benign breast diseases and breast cancer, and a separate chapter on male reproductive disorders and cancer.
  • NEW! Chapter on epigenetics and disease.
  • Additional What’s New boxes highlight the most current research and clinical development.

The book contains predominantly color illustrations, with some black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Kevin J Watson, BA, RRT (William Beaumont Hospitals)
Description: This sixth edition of a pathophysiology textbook includes more than 300 new full-color illustrations and photographs as well as major revisions, updated content, and reorganized data in many of the chapters. New information is provided on esophagitis and esophageal reflux, inherited disorders of the renal system, neuroregulation of hormone responses and hormonal immune system interaction, pain modulation, chronic pain syndromes, and classification of sleep disorders.
Purpose: The authors explore the ways in which the various cells, tissues, and organs suffer within the human body, providing a comprehensive overview of pathophysiology. The authors hope readers will realize that the conceptual models used in the book relate not only to the suffering of cells, tissues, and organ systems but also of human beings — there is a person on the receiving end of all that suffering or pathology. The revisions in this edition make it a valuable and comprehensive resource.
Audience: Although not specifically stated, the book is designed for college-level healthcare programs, but anyone interested in the pathophysiology of the human body would benefit from reading this well-written and logically organized book.
Features: The book is organized into two parts. Part one covers the central concepts of pathophysiology of cells and tissues or the cellular environment. The 13 chapters in this part cover cellular biology, altered cellular and tissue biology, the cellular environment, genes and genetic diseases, immunity, infection and cancer. Part two deals with the suffering or pathophysiology within each organ system and the interaction that can occur with multiple organ system failure. Each organ system is easily identifiable by the index color coding at the top of the fore edge of the page. There are 11 units in this part, made up of chapters 14-46. Each organ system discussion includes the male and female anatomy of the system if there are differences, alterations in those systems, and alterations specific for children. The book includes numerous full color artist conceptions, color and black-and-white photographs, tables, figures, a 22-page glossary and hypertext links to online resources. The online resource provides a more comprehensive glossary and multimedia content.
Assessment: This updated edition is well written and logically organized and can go toe-to-toe with any other pathophysiology textbook. This is an excellent choice for healthcare students and would provide a worthy resource for public, college, and university libraries as well.
Don Johnson
This third edition textbook is divided into two parts: central concepts related to cells and tissues, and pathophysiologic alterations. Part one gives an in-depth view of cells, genes and common genetic diseases, cell injury, fluid and electrolytes and acid-base balance, immunity, inflammation and wound healing, coping and illness, and oncogenesis. Part two gives a systematic survey of diseases within the systems that includes epidemiology, pathophysiology, clinical manifestations, and treatment modalities. The purpose is to provide an in-depth and current understanding of disease processes across the life span; to link relevant modern biology to a disease state; describe gender differences related to epidemiology and pathophysiology; and to integrate health promotion and disease prevention. Risk factors and nutrition are incorporated. The book is useful for practicing nurses and students in pathophysiology courses. The overall design is very logical. The first section provides a framework for understanding broad concepts such as genetics, cell injury, immunity, and inflammation. The second section examines normal anatomy and physiology, which serve as a basis for understanding common pathophysiology of adults and children. A new feature is "What's New Boxes," which present easy to understand updates in research. This textbook has always been an excellent resource and this new edition adds full color illustrations. There are algorithms that summarize important physiological and pathophysiological mechanisms. Students often indicate that these provide a quick means for review. Full-color photographs of clinical manifestations, specimens, and clinical imaging techniques add tothe text. Case studies are strategically included for each chapter dealing with disease states. New sections on headaches, neurobiology of selected psychiatric conditions, an integrated chapter on multiple interacting systems, and new illustrations make this text even better than previous editions.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780323065849
  • Publisher: Elsevier Health Sciences
  • Publication date: 11/19/2009
  • Edition description: Older Edition
  • Edition number: 6
  • Pages: 1838
  • Sales rank: 412,724
  • Product dimensions: 8.90 (w) x 11.00 (h) x 2.40 (d)

Table of Contents

1 Cellular biology 1
2 Altered cellular and tissue biology 45
3 The cellular environment : fluids and electrolytes, acids and bases 93
4 Genes and genetic diseases 123
5 Genes, environment - life-style, and common diseases 157
6 Innate immunity : inflammation 175
7 Adaptive immunity 211
8 Alterations in immunity and inflammation 249
9 Infection 293
10 Stress and disease 311
11 Biology of cancer 333
12 Tumor invasion and metastasis 375
13 Cancer in children 403
14 Structure and function of the neurologic system 411
15 Pain, temperature regulation, sleep, and sensory function 447
16 Concepts of neurologic dysfunction 491
17 Alterations of neurologic function 547
18 Neurobiology of schizophrenia, mood disorders, and anxiety disorders 605
19 Alterations of neurologic function in children 623
20 Mechanisms of hormonal regulation 655
21 Alterations of hormonal regulation 683
22 Structure and function of the reproductive systems 735
23 Alterations of the reproductive systems 771
24 Sexually transmitted infections 863
25 Structure and function of the hematologic system 893
26 Alterations of erythrocyte function 927
27 Alterations of leukocyte, lymphoid, and hemostatic function 955
28 Alterations of hematologic function in children 999
29 Structure and function of the cardiovascular and lymphatic systems 1029
30 Alterations of cardiovascular function 1081
31 Alterations of cardiovascular function in children 1147
32 Structure and function of the pulmonary system 1181
33 Alterations of pulmonary function 1205
34 Alterations of pulmonary function in children 1249
35 Structure and function of the renal and urologic systems 1279
36 Alterations of renal and urinary tract function 1301
37 Alterations of renal and urinary tract function in children 1337
38 Structure and function of the digestive system 1353
39 Alterations of digestive function 1385
40 Alterations of digestive function in children 1447
41 Structure and function of the musculoskeletal system 1471
42 Alterations of musculoskeletal function 1497
43 Alterations of musculoskeletal function in children 1547
44 Structure, function, and disorders of the integument 1573
45 Alterations of the integument in children 1609
46 Shock, multiple organ dysfunction syndrome, and burns in adults 1625
47 Shock, multiple organ dysfunction syndrome, and burns in children 1655
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Customer Reviews

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( 14 )
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Sort by: Showing all of 14 Customer Reviews
  • Posted December 29, 2008

    more from this reviewer

    This book is NOT for beginning nursing students

    I have used this book in advanced practice preparation and practice. This book is for the individual with an intermediate background in pathophysiology and wants to know more. Nurses are life long learners and as you practice in your profession you will see things that you want to understand better so that you can critically think about what is going on with your clients. This book will help, DON'T throw the baby out with the bath water. Keep this book on your shelf until the thirst for knowledge needs to be quenched, then pick up this book and drink it all in.

    4 out of 4 people found this review helpful.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted July 8, 2007

    Reference book for non-beginners

    I have to agree with some previous reviewers that it's very detailed and 'difficult'. The book outlines pathophysiology to chemical, cellular levels which sometimes get very complex. But that's the essences of this book. This book is not for beginner to learn the pathophysiology. To fully appreciate the fine details the book puts out, the reader must have absolute solid understanding of basic (and bit of intermediate) pathophysiology in addition to basic physioloy and biology. This book is not for quick reference purpose. It takes time to comprehend the complexity, but the human body is complex, too. But once you 'get it' you'll appreciate the knowledge the book revealed. Considering how complex the human body is, the book did a fine job of 'dividing' the body into chapters. So it's no surprising to me that I have to flip back and forth between chapters to understand something as a whole. I have been using this book since it's 2nd edition. It has gone through a lot of improvements, believe me. My husband and I are both critical care RNs and we both love it. I highly recommend this book for non-beginners. It is excellent reference book.

    3 out of 3 people found this review helpful.

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  • Anonymous

    Posted February 12, 2007


    Others that have rated this book poorly didn't have much nursing background. This book is not appropriate for the student who hasn't completed a year of nursing school. Otherwise it is an good reference book but not the one I turn to the most.

    2 out of 2 people found this review helpful.

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  • Anonymous

    Posted September 3, 2006

    Difficult to Comprehend

    I agree this is a bad text with important information buried in technical detail fit for a research scientist. I've never encountered another text this difficult to read. I have a degree in accounting and am taking this course as a prerequiste for a nursing program. There should have been prerequisites for this text.

    2 out of 2 people found this review helpful.

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  • Anonymous

    Posted June 29, 2009

    Great Book

    I bought this book because its the book suggessted for reference for my graudate study. I think its very good. I would recommend it for advance pathophysiology course but for basics Medical Surgical Books are still the best.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted September 23, 2006

    This book is pathological

    Very poorly written and difficult to comprehend.

    1 out of 2 people found this review helpful.

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  • Anonymous

    Posted September 30, 2012

    Improved from prev edition but still disorganized.

    Currently using book to assist in teaching class; previously used last edition.
    I find this version addresses certain phrases with better explanations, but in some topics the order of introduction is suboptimal. Many times certain subjects are explained in clearer ways significantly later in the same chapter. Diagrams are often arranged poorly in relation to the text; sheer number of images on certain pages is distracting from being able to read a topic without stopping.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted February 20, 2010


    The only problem was with the delivery time. This was for an online grad. level class. The delivery time was supposed to be 3 days. However, it took 7-8 days for the book to arrive. The first test was 2 days after the arrival.

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  • Posted May 9, 2009

    more from this reviewer

    Pathophysiology Masters Class

    I am currently taking advanced pathophysiology and I found this book to be a good source of basic information. But, since the book is published in 2006, it is lacking many new advancements in medicine. I find using current medical journals a much more accurate resource,

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  • Anonymous

    Posted June 16, 2006

    The worst text book ever written

    Text is heavily populated with extensive details to the extent that the main idea on every subject is hard to find. I have to use other books in order to find clear explanations about pathophysiology. Quantity does not equal quality.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted March 4, 2000

    Want a great book on diseases? This is the best I have found!

    I am a nursing student and I bought this book for additional information on diseases. I find this book easier to read and better structured than the required text I have bought for my nursing classes. The pre and post chapter sections make this book easy to understand and complete!

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  • Anonymous

    Posted December 5, 2009

    No text was provided for this review.

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    Posted November 18, 2008

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    Posted August 31, 2014

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