Pathophysiology of Disease An Introduction to Clinical Medicine, Sixth Edition / Edition 6

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Overview

NOW in full color!

A complete case-based review of the essentials of pathophysiology – covering all major organs and systems

4 STAR DOODY'S REVIEW!

"This is a great addition to the ranks of pathophysiology books for graduate students in medicine. It also is useful as a reference while on the wards as a memory jogger for basic anatomy, physiology, and pathology of common diseases. The addition of the full-color diagrammatic illustrations and tables and the

expanded case studies make the e book aesthetically pleasing and easily navigable. Overall, this is a great book to have on hand for the preclinical years, clinical years, and beyond!"--Doody's Review Service

This trusted text introduces you to clinical medicine by reviewing the pathophysiologic basis of the signs and symptoms of 100 diseases commonly encountered in medical practice. Each chapter first describes normal function of a major organ or organ system, then turns attention to the pathology and disordered physiology, including the role of genetics, immunology, and infection in pathogenesis. Underlying disease mechanisms are described, along with their systems, signs, and symptoms, and the way these mechanisms themselves determine the most effective treatment.

This unique interweaving of physiological and pathological concepts will put you on the path towards thinking about signs and symptoms in terms of their pathologic basis, giving you an understanding of the “whys” behind both illness and treatment.

Features

  • NEW full-color presentation
  • 111 case studies (22 new ones) provide an opportunity for you to test your understanding of the pathophysiology of each clinical entity discussed
  • A complete chapter devoted to detailed analyses of the cases
  • “Checkpoint” review questions appear throughout every chapter
  • Numerous tables and diagrams encapsulate important information
  • References for each chapter topic
  • NEW sections in the chapters on liver disease and inflammatory rheumatic diseases and a completely rewritten chapter on male reproductive tract disorders

Visit www.LangeTextbooks.com to access MP3 audio cases and other valuable resources.

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Editorial Reviews

Doody's Review Service
Reviewer: Brigit Elizabeth Ray, BA (University of Iowa Carver College of Medicine)
Description: New to this sixth edition of a graduate level pathophysiology book are full color tables and illustrations, new chapters on liver disease and inflammatory rheumatic diseases, a completely revised chapter on male reproductive tract disorders, and newly enhanced end-of-chapter case studies with full answer synopses in the back. Since publication of the previous edition in 2006, the authors have been hard at work updating and revising this book to incorporate the basic science concepts of anatomy, physiology, molecular biology, and pathology and integrate them with the applicable aspects of clinical medicine.
Purpose: The aim of this update is to "provide students with an introduction to clinical medicine through the study of diseases as manifestations of pathophysiology." The authors note that their intent is not to provide a comprehensive book, but an introductory one upon which to build during the clinical years of medical education with the additional understanding of signs and symptoms of disease, culminating in their management and treatment. The authors have done an outstanding job accomplishing these aims. Each chapter begins with the basic ingredients of anatomic and physiologic reviews of the organ system, then moves into the overarching concepts of how these processes may become disorderly. Finally, it describes how students can apply these concepts clinically to the medical diseases they will encounter in their patients on the wards. Each step of the way, students are able to recheck their understanding of the basic concepts and then fully integrate them into the end-of-chapter case studies.
Audience: Although targeted primarily at first or second year graduate students in medicine, the book also could serve as a reference for residents and general practitioners as well as graduate students in physiology and pathology. The editors are practitioners from UCSF and University of Michigan who have published extensively in their fields. Chapter authors, specialists in their respective areas, reference multiple evidence-based resources.
Features: This well-written, organized book explores the pathophysiology of diseases of all the major organ systems. Highlights include well-organized tables, bolded key terms in the text that correlate with the glossary, full-color diagrammatic depictions of physiological principles, and clinical presentations of common diseases. Internal chapter checkpoints closely correlate with the chapter objectives and maintain students' focus on important points.
Assessment: This is a great addition to the ranks of pathophysiology books for graduate students in medicine. It also is useful as a reference while on the wards as a memory jogger for basic anatomy, physiology, and pathology of common diseases. The addition of the full-color diagrammatic illustrations and tables and the expanded case studies make the book aesthetically pleasing and easily navigable. Overall, this is a great book to have on hand for the preclinical years, clinical years, and beyond!
From The Critics
Reviewer: Brigit Elizabeth Ray, BA (University of Iowa Carver College of Medicine)
Description: New to this sixth edition of a graduate level pathophysiology book are full color tables and illustrations, new chapters on liver disease and inflammatory rheumatic diseases, a completely revised chapter on male reproductive tract disorders, and newly enhanced end-of-chapter case studies with full answer synopses in the back. Since publication of the previous edition in 2006, the authors have been hard at work updating and revising this book to incorporate the basic science concepts of anatomy, physiology, molecular biology, and pathology and integrate them with the applicable aspects of clinical medicine.
Purpose: The aim of this update is to "provide students with an introduction to clinical medicine through the study of diseases as manifestations of pathophysiology." The authors note that their intent is not to provide a comprehensive book, but an introductory one upon which to build during the clinical years of medical education with the additional understanding of signs and symptoms of disease, culminating in their management and treatment. The authors have done an outstanding job accomplishing these aims. Each chapter begins with the basic ingredients of anatomic and physiologic reviews of the organ system, then moves into the overarching concepts of how these processes may become disorderly. Finally, it describes how students can apply these concepts clinically to the medical diseases they will encounter in their patients on the wards. Each step of the way, students are able to recheck their understanding of the basic concepts and then fully integrate them into the end-of-chapter case studies.
Audience: Although targeted primarily at first or second year graduate students in medicine, the book also could serve as a reference for residents and general practitioners as well as graduate students in physiology and pathology. The editors are practitioners from UCSF and University of Michigan who have published extensively in their fields. Chapter authors, specialists in their respective areas, reference multiple evidence-based resources.
Features: This well-written, organized book explores the pathophysiology of diseases of all the major organ systems. Highlights include well-organized tables, bolded key terms in the text that correlate with the glossary, full-color diagrammatic depictions of physiological principles, and clinical presentations of common diseases. Internal chapter checkpoints closely correlate with the chapter objectives and maintain students' focus on important points.
Assessment: This is a great addition to the ranks of pathophysiology books for graduate students in medicine. It also is useful as a reference while on the wards as a memory jogger for basic anatomy, physiology, and pathology of common diseases. The addition of the full-color diagrammatic illustrations and tables and the expanded case studies make the book aesthetically pleasing and easily navigable. Overall, this is a great book to have on hand for the preclinical years, clinical years, and beyond!
From The Critics
Reviewer: Brigit Elizabeth Ray, BA(University of Iowa Carver College of Medicine)
Description: New to this sixth edition of a graduate level pathophysiology book are full color tables and illustrations, new chapters on liver disease and inflammatory rheumatic diseases, a completely revised chapter on male reproductive tract disorders, and newly enhanced end-of-chapter case studies with full answer synopses in the back. Since publication of the previous edition in 2006, the authors have been hard at work updating and revising this book to incorporate the basic science concepts of anatomy, physiology, molecular biology, and pathology and integrate them with the applicable aspects of clinical medicine.
Purpose: The aim of this update is to "provide students with an introduction to clinical medicine through the study of diseases as manifestations of pathophysiology." The authors note that their intent is not to provide a comprehensive book, but an introductory one upon which to build during the clinical years of medical education with the additional understanding of signs and symptoms of disease, culminating in their management and treatment. The authors have done an outstanding job accomplishing these aims. Each chapter begins with the basic ingredients of anatomic and physiologic reviews of the organ system, then moves into the overarching concepts of how these processes may become disorderly. Finally, it describes how students can apply these concepts clinically to the medical diseases they will encounter in their patients on the wards. Each step of the way, students are able to recheck their understanding of the basic concepts and then fully integrate them into the end-of-chapter case studies.
Audience: Although targeted primarily at first or second year graduate students in medicine, the book also could serve as a reference for residents and general practitioners as well as graduate students in physiology and pathology. The editors are practitioners from UCSF and University of Michigan who have published extensively in their fields. Chapter authors, specialists in their respective areas, reference multiple evidence-based resources.
Features: This well-written, organized book explores the pathophysiology of diseases of all the major organ systems. Highlights include well-organized tables, bolded key terms in the text that correlate with the glossary, full-color diagrammatic depictions of physiological principles, and clinical presentations of common diseases. Internal chapter checkpoints closely correlate with the chapter objectives and maintain students' focus on important points.
Assessment: This is a great addition to the ranks of pathophysiology books for graduate students in medicine. It also is useful as a reference while on the wards as a memory jogger for basic anatomy, physiology, and pathology of common diseases. The addition of the full-color diagrammatic illustrations and tables and the expanded case studies make the book aesthetically pleasing and easily navigable. Overall, this is a great book to have on hand for the preclinical years, clinical years, and beyond!
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Product Details

  • ISBN-13: 9780071621670
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 10/20/2009
  • Edition description: Older Edition
  • Edition number: 6
  • Pages: 768
  • Product dimensions: 8.50 (w) x 10.90 (h) x 1.50 (d)

Meet the Author

Stephen J. McPhee, MD

Professor of Medicine

Division of General Internal Medicine

Department of Medicine

University of California, San Francisco

San Francisco, CA

Gary D. Hammer, MD, PhD

Millie Schembechler Professor of Adrenal Cancer

Director, Endocrine Oncology Program

Comprehensive Cancer Center

University of Michigan

Ann Arbor, MI

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Table of Contents

Key Features
Authors
Preface
1. Introduction, Stephen J. McPhee and Gary D. Hammer
2. Genetic Disease, Gregory Barsh
3. Disorders of the Immune System, Jeffrey L. Kishiyama
4. Infectious Diseases, Karen C. Bloch
5. Neoplasia, Mark M. Moasser
6. Blood Disorders, J. Ben Davoren and Sunny Wang
7. Nervous System Disorders, Catherine Lomen-Hoerth and Robert O. Messing
8. Diseases of the Skin, Timothy H. McCalmont
9. Pulmonary Disease, Thomas J. Prendergast, Stephen J. Ruoss, and Eric J. Seeley
10. Cardiovascular Disorders: Heart Disease, Fred M. Kusumoto
11. Cardiovascular Disorders: Vascular Disease, Igor Mitrovic
12. Disorders of the Adrenal Medulla, Tobias Else, Gary D. Hammer, and Stephen J. McPhee
13. Gastrointestinal Disease, Jason C. Mills, Thaddeus S. Stappenbeck, and Nigel Bunnett
14. Liver Disease, Mandana Khalili, Charles E. Liao, and Tung T. Nguyen
15. Disorders of the Exocrine Pancreas, Christopher J. Sonnenday, Diane M. Simeone, and Stephen J. McPhee
16. Renal Disease, Benjamin D. Parker and Joachim H. Ix
17. Disorders of the Parathyroids & Calcium & Phosphorus Metabolism, Dolores M. Shoback and Deborah E. Sellmeyer
18. Disorders of the Endocrine Pancreas, Janet L. Funk
19. Disorders of the Hypothalamus & Pituitary Gland, Tobias Else and Gary D. Hammer
20. Thyroid Disease, Douglas C. Bauer and Stephen J. McPhee
21. Disorders of the Adrenal Cortex, Tobias Else, Gary D. Hammer, and Stephen J. McPhee
22. Disorders of the Female Reproductive Tract, Karen J. Purcell and Robert N. Taylor
23. Disorders of the Male Reproductive Tract, Mikkel Fode, Jens Sonksen, Stephen J. McPhee, and Dana A. Ohl
24. Inflammatory Rheumatic Diseases, Allan C. Gelber, Stuart M. Levine, and Antony Rosen
25. Case Study Answers, Yeong Kwok, Eva M. Aagaard, and Jonathan D. Fuchs
Subject Index
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