Pathway Analysis for Drug Discovery: Computational Infrastructure and Applications [With CDROM] / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $20.95
Usually ships in 1-2 business days
(Save 83%)
Other sellers (Hardcover)
  • All (5) from $20.95   
  • New (3) from $95.82   
  • Used (2) from $20.95   


This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Read More Show Less

Editorial Reviews

From the Publisher
"Pathway analysis will help lead to a better understanding of the chemistry of living systems and the aberrations that disrupt health. This new book will serve as a beacon to research interested in this field." (Journal of Medicinal Chemistry, April 9, 2009)
Read More Show Less

Product Details

Meet the Author

ANTON YURYEV, PhD, is the Senior Director of Application Science at Ariadne Genomics Inc. His department studies the topological and evolutionary properties of biological networks and develops algorithms for pathway reconstruction and analysis of high-throughput data. Dr. Yuryev has published more than thirty scientific publications and is the author of several algorithms for primer design and pathway analysis.

Read More Show Less

Table of Contents



1 Introduction to Pathway Analysis (Anton Yuryev).

2 Software Infrastructure and Data Model for Pathway Analysis(Fedor Bokov and Anton Yuryev).

3 Automatic Pathway Inference in Heterogeneous BiologicalAssociation Networks (Anton Yuryev, Andrey Kalinin, and NikolaiDaraselia).

4 Algorithmic Basis for Pathway Visualization (SergeySimakov, Iaroslav Ispolatov, Sergei Maslov, and AlexanderNikitin).

5 Pathway Analysis of High-Throughput Experimental Data(Andrey Y. Sivachenko).

6 Integrative Pathway Analysis of Disease Molecular Data(Andrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and TatianaNikolskaya).

7 Whole-Genome Expression Profi ling of Papillary Serous OvarianCancer: Activated Pathways, Potential Targets, and Noise (JohnFarley, Laurent L. Ozbun, and Michael J. Birrer).

8 Mammalian Proteome and Toxicant Network Analysis (SeanEkins and Craig N. Giroux).

9 Unraveling Mechanisms of Toxicity with the Power of Pathways:ToxWiz Tool as an Illustrative Example (Mark P. Kühnel,Bojana Cosovic, Goran Medic, Robert B. Russell, and GordanaApic).

10 Impact of Chemistry Information on Pathway Analysis(Sreenivas Devidas).

11 Propagation of Concentration Perturbations in EquilibriumProtein Binding Networks (Sergei Maslov and IaroslavIspolatov).

12 An Adaptive System Model of the Yeast Glucose Sensor System(Todor Vujasinovic and André SinišaŽampera).

13 Present and Future of Pathway Analysis in Drug Discovery(Anton Yuryev).


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)