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More About This Textbook
Overview
It is rare indeed for one book to be both a first-rate classroom text and a major contribution to scholarship. The Pathway for Oxygen is such a book, offering a new approach to respiratory physiology and morphology that quantitatively links the two. Professionalism in science has led to a compartmentalization of biology. Function is the domain of the physiologist, structure that of the morphologist, and they often operate with vastly disparate concepts and procedures. Yet the performance of the respiratory system depends both on structural and on functional properties that cannot be separated.
The first chapter of The Pathway for Oxygen engages the student with the design and function of the vertebrate respiratory organs from a comparative viewpoint. The second chapter adds to that foundation the link between cell energetics and oxygen needs of the whole animal. With Chapter 3 the excitement begins—new ideas, fresh attacks on old problems, and a fuller account of the power of the quantitative approach Dr. Weibel has pioneered.
The Pathway for Oxygen will be read eagerly by medical students, graduate students, advanced undergraduates in zoology—and by their professors.
What People Are Saying
C. R. Taylor
This is clearly one of the most outstanding books in physiology/functional anatomy ever to be written.— C. R. Taylor, Alexander Agassiz Professor of Zoology, Harvard University
This is clearly one of the most outstanding books in physiology/functional anatomy ever to be written.
Product Details
Related Subjects
Meet the Author
Ewald R. Weibel is Professor of Anatomy, University of Bern, Switzerland.
Table of Contents
OXYGEN AND THE HISTORY OF LIFE
The Cell's Oxygen Sink and Energetics
Getting Oxygen to the Sink
Evolution of O2 Transport Systems
Evolution of External Gas Exchangers
Looking at the System as a Whole: Philosophy of the Approach
THE BODY'S NEED FOR OXYGEN
Levels of O2 Consumption
Estimating the Limits of O2 Consumption
LINKING STRUCTURE AND FUNCTION: MODEL, MEANS, AND TOOLS
How Does Structure Affect O2 Flow?
Are Animals Built Reasonably?
The Tools
CELL RESPIRATION
Gaining Energy from Combustion
Metabolic Pathways of the Cell
The Cell's Energetic Balance Sheet
MITOCHONDRIA: THE CELL'S FURNACES
Putting Some Order into Cell Metabolism
Oxidation-Phosphorylation Coupling Depends on Structure
Mitochondria and the Cell's Aerobic Potential
Mitochondria in Muscle Cells
THE VEHICLE FOR OXYGEN TRANSPORT: BLOOD AND CIRCULATION
The O2 and CO, Carrier: Blood
Moving Blood Around: Circulation
O2 Transport by the Blood
DELIVERING OXYGEN TO THE CELLS
Distributing Blood to the Tissues: Design of the Vasculature
The Microvascular Unit
O2 Flow from Blood to Cells
DESIGN AND DEVELOPMENT OF THE MAMMALIAN LUNG
Development of the Lung
Lung Histogenesis: Differentiation toward Gas Exchange
The Lung at Birth and Its Postnatal Maturation
LUNG CELL BIOLOGY
Organization of the Lung's Cell Population
A Closer Look at the Cells of the Gas Exchange Region
AIRWAYS AND BLOOD VESSELS
The Airway Tree
Ventilation
The Vascular Trees
Pulmonary Blood Flow
Ventilation-Perfusion Matching
THE LUNG'S MECHANICAL SUPPORT
External Support and Motive Force
The Pleural Cavity
The Lung's Fiber Skeleton
Surface Tension
Micromechanics and the Configuration of the Alveolar Septum
Keeping the Barrier Dry and Thin
THE LUNG AS GAS EXCHANGER
Design of the Gas Exchanger
Physiological Basis for Gas Exchange
Pulmonary Diffusing Capacity: Physiology
Pulmonary Diffusing Capacity: Morphometry
Structure and Function Compared
Matching the Conductance to O2 Needs: The Emergence of a Paradox
Resolving the Paradox: Models and Nature
THE RESPIRATORY SYSTEM IN OVERVIEW
Adjusting Performance to Needs
Adjusting Potential to Needs
The Limits to Potential: The Smallest Mammal
UNITS OF MEASUREMENT
GENERAL REFERENCES
INDEX