Peptide and Protein Design for Biopharmaceutical Applications / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $106.27
Usually ships in 1-2 business days
(Save 41%)
Other sellers (Hardcover)
  • All (7) from $106.27   
  • New (6) from $91.78   
  • Used (1) from $127.07   


Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create 'tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:
• Computer modeling of peptides and proteins
• Peptidomimetics
• Design and synthesis of cyclic peptides
• Carbohydrates in peptide and protein design
• De novo design of peptides and proteins
• Medical development applications
• An extended case study - the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Read More Show Less

Editorial Reviews

From the Publisher
"This book provides a comprehensive review of the many approaches undertaken over the yearsto develop peptide-based and peptide-mimetic-based drugs." (Journal of Medicinal Chemistry, June 2010)
Read More Show Less

Product Details

  • ISBN-13: 9780470319611
  • Publisher: Wiley
  • Publication date: 11/23/2009
  • Edition number: 1
  • Pages: 306
  • Product dimensions: 6.10 (w) x 9.20 (h) x 0.90 (d)

Table of Contents

List of Contributors.


1. Introduction (Knud J. Jensen)..

2. Computational Approaches in Peptide and Protein Design: An Overview (Garland Marshall and Gregory Nikiforovich)..

2.1 Introduction.

2.2 Basics and Tools.

2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4.



3. Aspects of Peptidomimetics (VeroniqueMaes and Dirk Tourwe)..

3.1 Introduction.

3.2 Modified Peptides.

3.3 Pseudopeptides.

3.4 Secondary Structure Mimics (Excluding Turn Mimics).

3.5 Examples of Peptidomimetics.

3.6 Conclusion.


4. Design of Cyclic Peptides (Oliver Demmer, A. O. Frank, and Horst Kessler)..

4.1 Introduction.

4.2 Peptide Cyclization.

4.3 Conformation and Dynamics of Cyclic Peptides.

4.4 Concepts in Rational Design of Cyclic Peptides.

4.5 Examples of Cyclic Peptides as Drug Candidates.

4.6 Conclusion.


5. Carbohydrates in Design of Peptides and Proteins (Knud J. Jensen and Jesper Brask)..

5.1 Introduction.

5.2 Configurational and conformational Properties of Carbohydrates.

5.3 Carbohydrates in Peptidomimetics.

5.4 Glycopeptides.

5.5 Carbohydrates as Scaffolds in the Design of Non-Peptide Peptidomimetics.

5.6 Sugar Amino Acids.

5.7 Cyclodextrin-Peptide Conjugate .

5.8 Carboproteins: Model Proteins on Carbohydrate Templates.

5.9 Conclusion Remarks.

6. De Novo design of proteins (Knud J. Jensen)..

6.1 Introduction.

6.2 Secondary Structure Elements.

6.3 Assembling a Specified Tertiary Structure from Secondary Structure Elements.

6.4 Proteins on Templates.

6.5 Foldamers.

6.6 Biopharmaceutical Applications of Protein De Novo Design.


7. Design of Insulin Variants for Improved Treatment of Diabetes (Thomas Høeg-Jensen)..

7.1 Introduction.

7.2 Diabetes Management and the Need for Insulin Engineering.

7.3 Insulin Structure.

7.4 Prolonged-acting Insulin Solids.

7.5 Prolonged-acting Insulin Solutions.

7.6 Fast-acting Insulins.

7.7 Glucose-sensitive Insulin Preparations.

7.8 Alternative Insulin Delivery.

7.9 Insulin Mimetics.

7.10 Pushing the Limitations of Insulin Engineering.

7.11 Conclusion.



Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)