Peptide Modifications to Increase Metabolic Stability and Activity

Overview

In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and prools include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides’ physical and biological properties by modification of the amino acid side chains and/or terminal...

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Overview

In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and prools include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides’ physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.

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Product Details

  • ISBN-13: 9781627036511
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/17/2013
  • Series: Methods in Molecular Biology Series , #1081
  • Edition description: 2013
  • Edition number: 1
  • Pages: 241
  • Product dimensions: 7.20 (w) x 10.10 (h) x 0.80 (d)

Table of Contents

1. Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides

Adel Nefzi

2. The Chemical Synthesis of α-Conotoxins and Structurally Modified Analogs with Enhanced Biological Stability

Jayati Banerjee, Reena Gyanda, Yi-Pin Chang, and Christopher J. Armishaw

3. Synthesis of AApeptides

Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai

4. Peptoids and Peptide – Peptoid Hybrid Biopolymers as Peptidomimetics

Maciej J. Stawikowski

5. Synthesis of Side Chain N,N′-diaminoalkylated Derivatives of Basic Amino Acids for Application in Solid-phase Peptide Synthesis

Jean-Philippe Pitteloud, Nina Bionda, and Predrag Cudic

6. Study Protein Folding and Aggregation Using Non-natural Amino Acid p-cyanophenylalanine as a Sensitive Optical Probe

Deguo Du, Haiyang Liu, and Bimlesh Ojha

7. AdamantoyLated Biologically Active Small Peptides and Glycopeptides Structurally Related to the Bacterial Peptidoglycan

Ruža Frkanec, Branka Vranešić, and Srdjanka Tomić

8. Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation

Maria C. Rodriguez and Mare Cudic

9. The Maillard Reaction Induced Modification of Endogenous Opioid Peptide Encephalin

Andreja Jakas

10. Solid-phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc-chemistry: Formation of Monosubstituted Guanidines

Nina Bionda and Predrag Cudic

11. Stabilization of Collagen-Model, Triple-Helical Peptides for In Vitro and In Vivo Applications

Manishabrata Bhowmick and Gregg B. Fields

12. Identification of Adipokine Receptor Agonists and Turning Them to Antagonists

Laszlo Otvos, Jr.

13. Peptide Detection and Structure Determination in Live Cells using Confocal Raman Microscopy

Andrew C. Terentis and Jing Ye

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