Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance: From Basic to Clinical Research

by E.E. Müller

Overview

Describes the ability of a series of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert a direct anti-neoplastic activity or to potentiate the activity of traditional chemotherapeutic agents on neuroendocrine and solid tumors. In addition, a new class of potent GH-releasers, GSHs/Ghrelin, endowed with important endocrine and extra-endcocrine action, is presented. Therefore, in addition to traditional chemotherapy, characterized by high toxicity and non-selective action on tumoral cells, the reader can find a new approach with more selective, less cytotoxic endocrine derived compounds.

Product Details

ISBN-13:	9788847021709
Publisher:	Springer Milan
Publication date:	10/08/2012
Edition description:	Softcover reprint of the original 1st ed. 2003
Pages:	197
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

LHRH/Somatostatin.- Chapter1 Twenty-five Years of Endocrine Oncology with Analogs of Hypothalamic Peptides: an Overview.- Chapter2 Analogs of Luteinizing Hormone-releasing Hormone in Benign Prostatic Hyperplasia and Advanced Renal Cell Carcinoma.- Chapter3 Luteinizing Hormone-releasing Hormone Antagonists in Gynecology.- Chapter4 Physiology and Pharmacology of Somatostatin and Its Receptors.- Chapter5 Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression.- Somatostatin/GHRH/GH.- Chapter6 Cortistatin: Not Simply a Natural Somatostatin Analogue.- Chapter7 Antineoplastic and Antiangiogenic Actions of Somatostatin Analogs.- Chapter8 Somatostatin in Clinical Endocrinology.- Chapter9 Antagonists of Growth Hormone-releasing Hormone in Oncology.- Chapter10 GH Receptor Antagonists: Basic Knowledge and Clinical Perspectives.- Ghrelin and Ghrelin Mimetics (GHS).- Chapter11 Hypothalamic Circuits Responsive to Ghrelin: Regulation by Leptin and Insulin.- Chapter12 Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System.- Chapter13 Endocrine and Extraendocrine Activity of Ghrelin and the GHS: Basic Research.- Chapter14 Endocrine and Nonendocrine Actions of Ghrelin and GHS: State of the Art in Clinical Research.- Hormonal Treatments for Endocrine-Dependent Tumors.- Chapter15 Hormonal Treatments of Endocrine-Dependent Tumors: Preclinical Aspects.- Chapter16 Hormonal Treatment of Endocrine-Dependent Tumors: Clinical Considerations.- Chapter17 Letrozole in the Treatment of Advanced Breast Cancer.