The Perricone Promise: Look Younger, Live Longer in Three Easy Steps

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An instant #1 "New York Times" bestseller now in paperback, this astonishing program will reportedly help readers reverse the aging process, inside and out.

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The Perricone Promise: Look Younger Live Longer in Three Easy Steps

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An instant #1 "New York Times" bestseller now in paperback, this astonishing program will reportedly help readers reverse the aging process, inside and out.

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Editorial Reviews

From Barnes & Noble
The Perricone promise is specific and simply stated: Dr. Nicholas Perricone has designed a groundbreaking, 28-day program to remove wrinkles, speed up metabolism and weight loss, and enhance mood, brain function, and overall health. The secret of this structured attack on aging is neuropeptides, the biggest new breakthrough in anti-aging medicine. As in earlier books, Perricone includes detailed advice about nutritional supplements and other skin aids.
Publishers Weekly
Dermatologist and bestselling author Perricone (The Perricone Prescription, etc.) takes his extensive knowledge of skin care and aging to a deeper level in his latest volume, explaining the science behind his theory that aging is intimately tied to inflammation. Perricone claims that certain peptides and neuropeptides (proteinlike substances found within the body) are key to maintaining health and longevity, and our food choices can boost their positive power. How one ages, Perricone says, largely depends on what one eats; the wrong choices have a crucial impact on wrinkles, degenerative diseases such as cancer and Alzheimer's, and can accelerate aging. Although Perricone doesn't offer a magic potion, he does claim his 28-day plan will decelerate the aging process by fighting inflammation. While the author's rather pricey topical products ($95 for a "face firming activator") are part of this complex program, the bulk of the text focuses on affordable options, such as purchasing "rainbow foods" (fresh fruits and vegetables), liberally using such healthy spices as oregano and basil, and consuming "superfoods" like barley, beans and hot peppers. Perricone also recommends natural supplements, including coenzyme Q10 and vitamin C ester, and provides a detailed plan that combines diet, exercise, supplements and topicals. Though the science-based text is sometimes weighty, readers seeking the logic behind their skin and health-care decisions won't be disappointed by the promises Perricone makes. Agent, Anne Sellaro. (Oct. 27) Forecast: Perricone is well-known and media savvy, and his products are sold in upscale stores. A hefty ad campaign (including print, TV, billboard and transit ads) should result in robust sales. Copyright 2004 Reed Business Information.
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Product Details

  • ISBN-13: 9780446695916
  • Publisher: Grand Central Publishing
  • Publication date: 10/25/2005
  • Edition description: Reprint
  • Pages: 320
  • Product dimensions: 7.12 (w) x 8.87 (h) x 0.87 (d)

Meet the Author

Nicholas Perricone, M.D.
Long recognized as a pioneer in reversing skin damage caused by aging, adjunct professor of dermatology at Michigan State University and No. 1-bestselling author Nicholas Perricone, M.D., has brightened the complexions of scores of readers with books like The Wrinkle Cure and The Perricone Prescription.


Nicholas Perricone, M.D., FACN, is a board certified clinical and research dermatologist. A brilliant scholar, Dr. Perricone completed medical school in just 2 1/2 years, graduating at the head of his class. He completed his internship in pediatrics at Yale Medical School and his dermatology residency at Ford Medical Center. Dr. Perricone is regarded as the father of the inflammation theory of aging. He is the author of the New York Times bestseller The Wrinkle Cure (Rodale Reach, May 2000). Warner Books published the trade paper edition in May of 2001. It reached No. 1 on both the New York Times and the Los Angeles Times bestseller lists on March 24, 2002, and remained there for four weeks. Close to one million copies are in print. His PBS-TV special of the same name is one of the top fundraisers for public television.

Dr. Perricone is certified by the American Board of Dermatology, is a fellow of the New York Academy of Sciences and a fellow of the American College of Nutrition. He is also a fellow of the American Academy of Dermatology and the Society of Investigative Dermatology. He is the recipient of the 2002 Eli Whitney Award, awarded annually to an outstanding individual for significant contribution to science.

Prior recipients include National Medal of Science recipient, Igor Sikorsky, (founder of Sikorsky aircraft) inventor of the first practical helicopter, which established the bedrock upon which today's helicopter industry rests, and Buckminster Fuller, inventor of the geodesic dome -- the lightest, strongest, and most cost-effective structure ever devised.

Dr. Perricone holds dozens of U.S. and international patents for the treatment of skin and systemic disease, and for the use of topical anti-inflammatories for reversing and preventing damage to skin caused by age, the sun, the environment, hormonal changes, etc. He is the author of numerous scientific articles documenting the results of his research and is a contributing editor to the peer-reviewed medical journal Skin and Aging and is a member of the editorial board of Archives of Gerontology & Geriatrics. He is chairman of the International Symposium on Aging Skin, an annual meeting in which researchers come together from around the world to share their latest scientific breakthroughs in the prevention of aging and aging skin.

Vogue magazine has named Dr. Perricone one of the top four dermatologists in the United States.

His book The Perricone Prescription, A Physician's 28-Day Program for Total Body and Face Rejuvenation, was published by HarperCollins to coincide with the premiere of his second television special for PBS-TV, the leading national educational television network, in September 2002.

Author biography courtesy of HarperCollins.

Good To Know

When Kim Cattrall had a skin emergency while filming HBO's Sex and the City, Perricone was summoned to the set to deliver a vitamin-enriched moisturizer that saved the day.

According to Dr. Perricone, the two best things you can add to your diet are salmon and berries.

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    1. Hometown:
    1. Education:
      Michigan State University

Read an Excerpt

The Perricone Promise

By Nicholas Perricone

Warner Books

Copyright © 2004 Nicholas V. Perricone, M.D.
All right reserved.

ISBN: 0-446-50016-X

Chapter One

The Perricone Promise

The world is so fast that there are days when the person who says it can't be done is interrupted by the person who is doing it. -ANONYMOUS

The universe is full of magical things, patiently waiting for our wits to grow sharper. -EDEN PHILLPOTTS

WHAT IF I WERE TO TELL YOU that we are on the threshold of a revolution that can reverse the signs of aging? And that with this book in hand, by following just three simple steps, you can start reaping these benefits today?

When I wrote The Wrinkle Cure and The Perricone Prescription, I introduced the Inflammation-Aging Connection-the concept that inflammation at the cellular level is the single most powerful cause of the signs of aging. That's not to mention the correlation between inflammation and such chronic diseases as arthritis, diabetes, Alzheimers, cancer, and strokes.

The extensive research and the resulting solutions I introduced still hold true today, and thousands of people have reported how much better they look and feel after following my program.

I could have discontinued my research there. But I knew there was more to learn. I knew that if inflammation was at the root of aging, something deeper must be able to mediate that inflammation. That "something deeper" turns out to be the biggest breakthrough in anti-aging medicine in years: protein-like substances in our bodies called peptides and neuropeptides.

Peptides are compounds consisting of two or more amino acids (the building blocks of proteins), chained together by what is called a peptide bond.

Neuropeptides are peptides released by neurons (brain cells) as intercellular messengers. Some neuropeptides function as neurotransmitters, and others function as hormones.

Peptides and neuropeptides, like many substances in our bodies (think cholesterol) can work both for and against us. The good news is that by following the program in The Perricone Promise, you can dramatically increase the positive effects of anti-inflammatory peptides and neuropeptides and greatly decrease their negative influences.

As a result, you will experience dramatic changes not only in the way you look, but also in the way you feel. In just twenty-eight days, you can erase what seems like ten years from your face and body. With The Perricone Promise, you'll learn to help reverse the aging process and add many more youthful years to your life.

Look Better, Feel Better in Three Easy Steps

As a dermatologist, my primary interest and concern is how my patients look. Is your skin clear and healthy? Is your skin radiant and glowing, or is it dull and sallow? Is your skin heavily lined and wrinkled, or is it toned and supple? This concern does not stem from an obsession with youth or with looking like a model or film star. The answers to these questions are prime indicators of overall health. Your face and body are constant, visible monitors of how well or how poorly you are aging. Looking good and having a positive body image is not vanity; it is your road to a long, healthy, and happy life. This is one of the key reasons that I chose dermatology as a medical specialty-to be able to find new ways to achieve these highly visible goals regardless of chronological age.

My promise to you is that you can achieve these goals-looking younger and living longer-by following the three easy steps included in this book:

Step 1. DIET. A revolutionary nutritional program that includes the Ten Superfoods to help reduce inflammation and rejuvenate the skin and body.

Step 2. SUPPLEMENTS. In addition to eating well, these multipurpose and highly effective nutritional supplements will increase production of the anti-inflammatory peptides and neuropeptides, your body's natural anti-aging weapons.

Step 3. TOPICALS. Working from the outside in, these newly formulated neuropeptide-based creams will have you looking younger almost instantly.

Throughout the rest of this book, you'll find ways of unleashing the power of neuropeptides to:

Increase production of collagen and elastin.

Repair scars and wrinkles.

Increase circulation, resulting in breathtaking radiance and glow.

Experience rapid wound repair.

Develop a dewy, supple appearance to skin that you haven't seen since your teens.

But this book is not just about the way you look. By following this simple three-step program, you can rejuvenate not only your skin, but also your brain, your emotional state, and your overall health. Increasing the power of positive peptides can result in such diverse effects as:

Decreased inflammation in every organ system.

Increased efficiency of metabolism, resulting in cellular repair.

Elevated mood.

A strong and healthy heart that is resistant to disease.

Denser bones as you age.

Decreased risk of certain forms of cancer.

Repair of the skin.

Normalized metabolism for losing weight while retaining youth.

A rejuvenated immune system.

The Brain-Beauty Connection

Each step I have taken in my career has led me to uncover secrets that go deep beneath the surface of the skin. When I began my research into peptides and neuropeptides, my goal was to help solve my patients skin problems. I wanted to find ways to help them look healthier and younger.

How exciting, then, to discover that my research had much greater benefit than I ever imagined. It turns out that boosting the positive powers of peptides and neuropeptides will not only help you look healthier and younger, but actually help you maintain the health of every system and organ in your body-and even give you an edge on reversing the aging process. And its all due to the Brain-Beauty Connection.

Prior to the discovery of neuropeptides, control of the brain and nervous system was thought to be accomplished through a complicated network of neurotransmitters (such as serotonin and dopamine), hormones (like adrenaline and cortisol), and enzymes.

Today, we know that matters are infinitely more complex. As brain researcher Dr. Steve Henricksen once put it, "We used to think the brain was like a computer. Now we think each cell is like a computer, a separate computer. And one single cell is like the whole brain."

If the brain is at all like a collection of integrated, high-speed computers, neuropeptides seem to form the electrochemical communications web that keeps them balanced and working in unison.

There are cells in the brain that produce various neuropeptides, and these neuropeptides do just about everything. They can be either pro-inflammatory or anti-inflammatory. They are responsible for many functions: They control our mood, energy levels, pain and pleasure reception, body weight, and ability to solve problems; they also form memories and regulate our immune system. These active little messengers in the brain actually turn on cellular function in the skin. (Its interesting to note that the immune system is an extension of the brain, and that the skin is an immune organ.)

Beauty Is Much More Than Skin Deep

When I was a medical student, we studied embryology. There I learned that three layers of tissue develop into every organ system in our bodies. One fact that particularly intrigued me was that the same layer of tissue that was responsible for the production of the brain also produced skin. That is why, when we eat a food or take a nutritional supplement that is therapeutic for the brain, the skin improves. This simple fact shaped much of my research into the role of peptides and neuropeptides in the Brain-Beauty Connection.

While manipulating the neuropeptides, neurotransmitters, and hormones that are in the brain to help create younger, more beautiful skin, increase longevity, and slow the aging process might seem more at home in a Michael Crichton or Robin Cook novel, believe me when I tell you that it is not only possible, but in fact the new reality.

Scientists now know that these neuropeptides, neurotransmitters, and hormones have a vast cellular communications system. Neuropeptides are natures "cell" phones. There is a trio controlling every aspect of our bodies, using neuropeptides as their messengers. That is, the brain signals the thymus, which is the master gland of immunity (more about this in chapter 2); the thymus signals the skin; and the skin talks back to the brain. Every messenger has a recipient for its message. These recipients are known as receptor sites. Think of it as "cellular communication": The cells communicate in the same way as making a phone call from your phone (the messenger) to another phone, which is there to receive the call (the receptor site). There is no voice mail here-it is a world in which (for good or ill) every call is answered, instantly.

The message delivered at the receptor site depends upon the particular neuropeptide, neurotransmitter, or hormone making the call. If high levels of the potentially harmful neuropeptide Substance P (which you will also learn more about in chapter 2) are being released in the brain, for example, we will experience "psychic pain"-we will feel depressed and anxious. Substance P has receptor sites throughout the body, including in the skin, so the message or call sent to the receptors in the skin might be: "Were depressed. Lets turn on inflammation in our skin cells today."

The result? Accelerated aging of the skin through abnormal cell turnover, loss of radiance and tone.

So the brain sends messages to the skin. But remember, this "phone system" circuitry goes both ways. We now know that just by touching the skin, we can actually change the circuitry in our brain! This is an amazing concept if we take a minute to think about it. Usually we think it takes a powerful drug or surgical or therapeutic procedure of some sort to make any kind of significant change in the body or mind. However, studies have shown that just fifteen minutes of daily massage help premature infants gain weight faster, enabling them to leave the hospital sooner than their counterparts. The massaged babies are more relaxed, active, and alert. Six months later, they continue to be more advanced.

Studies in orphanages and hospitals repeatedly tell us that infants deprived of skin contact lose weight, become ill, and even die. Infants who are held cry less than those who are not, their immune systems are enhanced, and they handle stress more efficiently.

The need for touch continues throughout our lives. When diabetic children were massaged for a month, blood glucose levels decreased and they were able to reduce their medication levels. Asthmatic children had fewer attacks. Massage helped children with autism, severe burns, cancer, and arthritis. These are perfect illustrations of how neuropeptides can be activated in the brain from touch receptors in the skin. And the neuropeptides released, such as endorphins, send a healing, positive message to the brain.


I recently spoke with Jim Parker of the Do It Now Foundation, who shared with me some fascinating information on the world of neuropeptides back when they were first known as endorphins. They were going to be the "magic bullets" of psychopharmacology, miraculous chemical keys to unlock the secrets of pleasure and pain, joy and sorrow, memory, intelligence, and behavior. They were supposed to explain everything from falling in love to falling asleep, and a full understanding of their actions and effects was going to cure drug addiction and mental illness, regulate mood and appetite, and even heighten creativity and sexual response. They were the endorphins, the internally produced morphine-like substances responsible for an array of drug-like effects in the body, and for a while after their 1975 discovery, everyone wanted to speculate about them. But the euphoria didn't last. Life got complicated as research findings grew confusing, then contradictory. As the number of identified endorphins grew from month to month, and scientists understanding of their many effects broadened, they became known as endogenous opioids, and finally neuropeptides, of which endorphins form a small subcategory. Investigators continued to look hard and long at the powerful new body of chemicals and quietly went about the difficult work of figuring them out-or at least figuring out a way to figure them out. In the process, they linked them with a vast array of physical and emotional problems-as both possible causes and potential cures-and the prognosis is now good for at least some of the promised early magic bullets to hit their mark. In human terms, for the millions of people afflicted with a wide range of problems from alcoholism and obesity to chronic pain and schizophrenia, the study of neuropeptides holds great promise.

One of the great joys of practicing dermatology is seeing immediate, visible effects when the right treatment is applied to a particular condition. This has been a great motivator for me throughout my career, and it continues to provide the inspiration for spending many hours in the laboratory looking for that next miracle ingredient that can truly deliver results to the skin.

For far too long, the beauty and skin care industry has focused on the look and feel of a product-its packaging and its perfume, as opposed to genuine efficacy. Since I first introduced topical formulations containing highly active ingredients such as alpha lipoic acid (ALA) and dimethylaminoethanol (DMAE), retailers have had a hard time keeping their shelves stocked with these products. A new generation of women and men is controlling the marketplace-a generation that not only wants but actually demands products that work overtime to keep them as young looking and as vital as possible. I think this is an excellent development, because it has now involved many major corporations in serious research aimed toward resolving the problems of aging skin.

However, there is a somewhat alarming trend toward obtaining serious (and very costly) surgical procedures at a younger and younger age. Just turn on the TV and you will see some young woman, still in her teens, vying for radical surgery to turn herself into a clone of the current hot actress, model, or singer. America seems to be gripped by manic, radical makeover madness. According to a New York Times article, "A Lovelier You, With Off-the-Shelf Parts" by Alex Kuczynski (May 2, 2004), Americans underwent 8.3 million cosmetic surgery procedures in 2003, an increase of 12 percent over the previous year.

In addition to all the surgery, new fillers designed to plump up facial lines are being rushed to market. Use of Botox, a neurotoxin (neuro means "nerve"; toxin means "poison") that paralyzes muscles to smooth out wrinkles and expression lines, is rampant.


Excerpted from The Perricone Promise by Nicholas Perricone Copyright © 2004 by Nicholas V. Perricone, M.D.. Excerpted by permission.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.

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Customer Reviews

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Sort by: Showing all of 6 Customer Reviews
  • Anonymous

    Posted August 18, 2005

    Not for the weak of wallet...

    I purchased this book post Oprah. I should have known then to proceed with monetary caution. Warning: the following statement may appear to be hateration, but is actually admiration. I dream of the day when I can afford cosmetic surgery. I wouldn't necessarily get it, but it would be nice just to know that I could afford it. If perchance you fall into the category of people who can afford cosmetic surgery, RUN to the bookstore, get this book before going to the surgeon. Dr. Perricone is about to save you money, time, and pain. However, for the rest of us working class people who not only are trying to get ends to meet, but have them sit down and be civil with each other, the next part of this review is for you. After reading Dr. Perricone's book, I now dream of the day that I can afford to purchase wild Alaskan Salmon by the case. Granted, beans are affordable, but I'm not going to eat the bloody buggers every day. If nothing else, I have had it reinforced that I need to reduce or avoid high glycemic foods (starchy veggies, starchy grains, and certain fruits), eat lots of vegetables, throw in a few fruits, and drink lots of water. Pretty much the same information spewed by the American Diabetic Association and other 'diet' gurus re-packaged to sell new hopes and dreams. Now before those of you who have read this book get all bent out of shape, allow me the time to state that this book does contain some valuable and very detailed information about 10 superfoods, herbs, and spices. However, I've bought this same info at the corner health food store ala Dick Gregory and the Black Muslims in a more concise and affordable format. But I understand everybody's got to make a living. Everybody's got to get their hustle on.

    3 out of 6 people found this review helpful.

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  • Anonymous

    Posted March 10, 2005


    Popular author of 'The Wrinkle Cure' and 'The Perricone Prescription,' Nicholas Perricone, M.D. now offers 'The Perricone Promise' in which he once again touts his program for looking younger, feeling better, and living longer. His premise is pretty much the same save for the addition of the 'Brain-Beauty Connection,' which many have seen on PBS. No stranger to startling announcements, he makes another - that you will see benefits in as little as three days. Through Perricone millions have become familiar with such scientific names as peptides and neuropeptides, which he maintains give new life to skin and hair, aid in heart health, and even decrease the risk of certain forms of cancer. 'Wrinkled, sagging skin is not the inevitable result of growing older,' Dr. Perricone has declared. 'It's a disease, and you can fight it. You can look your best, feel your best, and enjoy beautiful skin and optimum health every day of your life, provided you start right now. And you don't need expensive, invasive plastic surgery to do it.' The host of several well-watched PBS programs, Perricone's credentials are impressive: a degree in Medicine from Michigan State University, an internship in Pediatrics at Yale University School of Medicine, and certification by the American Board of Dermatology. After more than two decades of study Dr. Perricone emphatically declares that 'a high protein, low carbohydrate diet full of salmon, fresh blueberries, cantaloupe and spring water can help slow and even reverse the aging process.' In other words the clock can be turned back. Is there an accompanying product line? Of course. Among his best selling items are 'Amine Complex Face Lift,' a daily facial treatment geared to nourishing the skin, retaining moisture, and ridding the skin of excess oil production; and 'Evening Facial Emollient,' a skin restorative that aids in cellular renewal while promoting an even skin tone and glow. Similar in tone to his previous books, Perricone's latest is pretty straight forward stuff, a bit like a lecture. Lloyd Sherr gives and able, distinct reading.

    1 out of 2 people found this review helpful.

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  • Anonymous

    Posted November 23, 2004

    Feel Good And Look Good

    I use The Perricone Promise because I believe in natural look good, feel young remedies to slow the aging process. The book basically asks you to promise to do three things that you probably do daily anyway: eat, take vitamins and apply a daily skin routine. The recipies at the back of the book make it easy to plan meals and the few obscure ingredients mentioned in other reviews are not that hard to find. It's just a matter of slightly adjusting the that way you shop. (Let's face it -- it would take a lot of extra time in the grocery isle choosing the right foods before the minutes would add up to the six or so weeks of downtime to recover from the knife.) Yes it is costly to follow the supplements/lotions but I can justify the time and money I spend on these three steps in an effort to avoid surgical procedures. If you have already invested in plastic surgery or if you are thinking you'll soon jump on the surgery or Botox bandwagon then this health regime may give you a decade or more to budget for the more invasive 'still lookin' good' solutions. I've read several of the bestselling self-help books so I am confident in recommending The Perricone Promise.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted March 29, 2005

    Wonderful for IBS as well

    Wonderful book. Very clear and easy to follow diet guidelines. I highly recomend this book. I have been on this eating plan for over 6 months and have had more than just better skin. It has greatly helped with many symptoms of my IBS and other inflammatory ailments. Small cuts and scrapes heal faster and I don't seem to have as many sinus infections. This diet has seemed to greatly decrease the amount of inflamation in my body. I have tried many diets/plans to help my constant pain and suffering with IBS, this has been the BEST yet and I look better and feel younger. Give it a try!

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    Posted February 2, 2013

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    Posted May 13, 2011

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