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A Guide for Research and Clinical Evaluation
Edited by J. Paul Robinson and George F. Babcock
Since 1908, when the Nobel prize was awarded to two doctors who proposed the primary role of phagocytes in the body's defense system, this theory of cell function has steadily gained acceptance. In fact, the past fifteen years have seen phagocyte research blossom into a sophisticated tool for understanding the immune system. Today, the ability to evaluate the abnormalities of phagocytes—or cells that ingest foreign particles and debris—is integral to the treatment of AIDS, cancer, severe burns, and a host of cell diseases.
Phagocyte Function is the first volume in an important new series that will embrace all cytometric methods. This authoritative text, featuring individual chapters written by leading researchers and clinicians, is designed to provide both novice and expert with a complete understanding of phagocyte function. The volume's extensive range covers everything from the basic concepts needed to understand phagocyte activity, to the clinical applications necessary for evaluation and diagnosis, including flow cytometry, confocal microscopy, and image analysis.
This comprehensive reference manual includes:
* The role of cellular receptors and signal transduction
* New pathways for studying respiratory burst mechanisms
* The functional role of monocytes/macrophages in health and disease, including clinical syndromes and macrophages in wound treatment
* Single-source coverage that combines parallel research on both neutrophils and macrophages
Phagocyte Function is an indispensable resource for clinical and biomedical researchers in the fields of cytometry, immunology, oncology, cell biology, and microbiology who routinely measure functional abnormalities of phagocytes. Phagocyte Function is as useful in the classroom as it is in the laboratory or clinic.
Incl. role of monocytes/macrophages in health & disease; clinical syndromes & macrophages in wound trmt.
|1||Analysis of the Phagocyte Membrane Lectin CR3 Using Fluorescence-labeled Polysaccharides and Flow Cytometry||1|
|2||Cytometric Approaches to the Study of Receptors||19|
|3||Pathophysiology of Human Fc-gamma Receptors in Health and Disease||47|
|4||Early Events in Receptor-Mediated Neutrophil Signal Transduction||77|
|6||Lipopolysaccharide-Binding Proteins and Receptors||125|
|7||Actin Polymerization in Human Neutrophils||155|
|8||Neutrophil Phagocytosis: Influence of Opsonins, Neutrophil Activation, and Microbial Characteristics||187|
|9||Oxygen and Nitrogen Reactive Metabolites and Phagocytic Cells||217|
|10||Neutrophil - Endothelial Cell Interactions||253|
|11||The HL-60 Cell: A Cell Culture Model for Studying Phagocyte Cell Functions||277|
|12||Risk Assessment for Intensive Care Patients by Automated Classification of Flow Cytometric Data||289|
|13||Alterations in the Nonspecific Immune Response Following Severe Traumatic Injury||307|
|14||Human Monocytes and Macrophages: Characterization in Health and Inflammatory Disease States||327|
|15||The Role of Monocytes/Macrophages in Wound Healing||349|
|16||Monocytes and Macrophages in Solid Organ Transplantation: Important Implications for the Future of Transplant Immunology||359|